Articles tagged "Outcome"

2021 American Transplant Congress
Improved Patient Survival in DCD Liver Transplantation
O. Bushara¹, J. Alhalel¹, H. Azad¹, T. Cerri², S. Zafer², J. C. Caicedo¹
¹Department of Surgery, Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rosalind Franklin Medical School, Chicago, IL
*Purpose: We aim to investigate longitudinal outcomes in DCD liver transplantation over a 10-year period and elucidate trends in patient survival, biliary complication rates, and…
2021 American Transplant Congress
Machine Learning Approaches for Post-transplant Kidney Outcome Prediction
H. Ghali¹, D. Won¹, S. Yoon¹, A. Friedman²
¹Systems Science and Industrial Engineering, SUNY Binghamton, Binghamton, NY, ²LiveOnNY, New York, NY
*Purpose: Determine a robust prediction model for kidney graft survival based on analyzing a combination of decisive factors such as donor and recipient characteristics, biopsy,…
2021 American Transplant Congress
Liver Biopsy as a Predictor in Risk Stratification for Heart Transplant Candidates
S. Tolia¹, T. Al Saadi¹, N. Narang², A. Joshi², C. Sciamanna², S. Pauwaa², G. Macaluso², M. Dia², A. Tatooles³, P. Pappas³, W. Cotts², A. Andrade²
¹Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, ²Cardiology, Advocate Christ Medical Center, Oak Lawn, IL, ³Cardiovascular Surgery, Advocate Christ Medical Center, Oak Lawn, IL
*Purpose: Patients undergoing workup for Orthotopic Heart Transplant (OHT) undergo multi-organ evaluation for risk stratification. While cirrhosis is a known predictor of poor outcomes in…
2021 American Transplant Congress
Clinical and Molecular Profiling Can Help in Predicting the Response to Alemtuzumab Treatment in Kidney Transplant Recipients with Severe or Glucocorticoid-Resistant Acute Rejection
D. M. Peelen¹, M. van der Zwan¹, M. C. Clahsen-van Groningen², D. A. Mustafa², C. C. Baan¹, D. A. Hesselink¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Pathology, Erasmus MC, Rotterdam, Netherlands
*Purpose: Alemtuzumab is an effective drug for the treatment of severe or glucocorticoid-resistant acute kidney allograft rejection (AR), but can also cause severe adverse events.…
2021 American Transplant Congress
Liver Dysfunction Following Lung Transplantation
E. J. Hyzny¹, E. G. Chan¹, J. P. Ryan¹, T. Harano¹, M. R. Morrell², P. G. Sanchez¹
¹Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To describe the incidence and risk factors for postoperative hepatic dysfunction (POHD) following lung transplantation (LT) and long-term outcomes for these patients.*Methods: We performed…
2021 American Transplant Congress
Immunologic Endotypes of Ischemia-reperfusion Injury in Human Liver Transplantation
R. A. Sosa, A. Q. Terry, F. M. Kaldas, B. V. Naini, T. Ito, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft rejection in orthotopic liver transplantation (OLT), involving complex interactions between innate and adaptive immune…
2021 American Transplant Congress
Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes
P. Saravanan, J. Kalivarathan, M. Levy, M. Kanak
Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA
*Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…
2021 American Transplant Congress
Does the Timing of Subclinical Acute Rejection After Kidney Transplant Matter?
P. Portocarrero¹, S. Park², K. Guo³, L. Zhao³, J. Friedewald²
¹Nephrology, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: We hypothesized that the timing of subclinical acute rejection (subAR) diagnosed with biopsy, gene expression profile or donor-derived cell-free DNA is associated with poor…
2021 American Transplant Congress
Trends and Outcomes Analysis of U.S. Transplant Centers Performing High Volumes of Hard to Place Kidneys
D. Bahl¹, A. Mahajan², H. Aramada³, Y. Qazi³
¹St. George's University, St. George's, Grenada, ²University College Cork School of Medicine, County Cork, Cork City, Ireland, ³Keck Hospital of USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, discard rate remains significantly high. The UNOS SRTR data now provides information on all…
2021 American Transplant Congress
Early Conversion to Belatacept-based Therapy Improves Graft Function in Renal Transplant Patients
N. Huang¹, C. J. Yang², I. Movileanu¹, R. H. Dvorai³, K. M. Ecal¹, R. F. Saidi¹, A. N. Ayla Senay¹, B. Gallay⁴, M. J. Hanlon¹, S. Narsipur⁴, M. R. Laftavi¹, R. Shahbazov¹
¹Surgery, SUNY Upstate Medical University, Syracuse, NY, ²Pharmacy, SUNY Upstate Medical University, Syracuse, NY, ³Pathology, SUNY Upstate Medical University, Syracuse, NY, ⁴Medicine, SUNY Upstate Medical University, Syracuse, NY
*Purpose: Our goal in this study was to assess the impact of early vs late conversion to Belatacept based (Bela) IS in kidney transplant (KT)…