Articles tagged "Obesity"

2021 American Transplant Congress
The Role of Histone Acetylation/methylation Mediated Epigenetic Modifications in the Pathogenesis of Non-alcoholic Steatohepatitis-associated Liver Carcinogenesis
P. K. Rajan¹, U. Utibe-Abasi¹, J. D. Sanabria¹, M. Banerjee², G. Smith¹, M. S. Schade¹, J. Sanabria¹, K. Sodhi¹, S. Pierre², Z. Xie², J. I. Shapiro², J. Sanabria¹
¹Department of Surgery, Marshall University, Huntington, WV, ²Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, Huntington, WV
*Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers and is characterized by an acquisition of multiple abnormal phenotypes driven by epigenetic…
2021 American Transplant Congress
Obesity is Associated with Greater Gender Disparity in Access to Kidney Transplantation
S. S. Sheikh, B. Orandi, P. MacLennan, H. Qu, R. M. Cannon, D. Anderson, M. Hanaway, S. Mehta, V. Kumar, R. Reed, J. Locke
Surgery, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity and female gender have been associated with decreased access to kidney transplant. We sought to use contemporary data to examine the likelihood of…
2021 American Transplant Congress
Utilization of Pre-Procurement Donor Liver Biopsy in Donation-after-circulatory-Death Liver Transplantation
A. C. Bolognese¹, N. Neidlinger¹, C. Sparks², A. Schneider², A. M. D'Alessandro¹, D. P. Foley¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²UW Organ and Tissue Donation, Madison, WI
*Purpose: Careful selection of suitable DCD donor livers is critical to obtain optimal transplant outcomes. In order to identify potentially suitable livers prior to DCD…
2021 American Transplant Congress
Multistep Algorithm to Achieve Weight Loss Goal in Advanced Stage Obesity Kidney Transplant Candidates: A Single Center Preliminary Report
A. Shah, J. Galpern, L. Castaldo, P. Touhy, M. Thomas, A. Aaron, M. Fruscione, L. Dageforde, N. Elias
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Obesity causes and complicates glomerulonephritis and chronic kidney disease (CKD) leading to end stage renal disease (ESRD). Kidney Transplantation (KT) improves ESRD patients’ survival…
2021 American Transplant Congress
Liver Transplantation with Super Obese Donors (BMI≥50) Grafts: An Acceptable Pathway to Expand the Donor Pool. Analysis of the OPTN/UNOS Liver Transplant Registry
P. Vargas¹, C. Argo², H. Zachary², M. Stotts², N. Intagliata², P. Northup², J. Oberholzer¹, S. Pelletier¹, N. Goldaracena¹
¹Transplant Surgery, University of Virginia Health System, Charlottesville, VA, ²Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA
*Purpose: We aimed to analyze the impact of donor body mass index (BMI) on recipient morbidity and survival following liver transplantation (LT).*Methods: The UNOS-STAR database…
2021 American Transplant Congress
Cellular Landscape of Steatotic Livers Revealed by Single-nuclei Rna Sequencing
C. Kuscu¹, C. Kuscu¹, A. Shetty², E. Bardhi³, T. Rousselle⁴, J. Eason¹, M. Sraj⁵, D. Maluf⁶, V. Mas⁴
¹Surgery, James D Eason Transplant Institute, Memphis, TN, ²University of Maryland, Institute for Genome Sciences, Baltimore, MD, ³Program in Transplantation - University of Maryland, Baltimore, MD, ⁴Surgery, Division of Surgical Science, Baltimore, MD, ⁵Surgery, University of Maryland, Baltimore, MD, ⁶Surgery, Program in Transplantation - University of Maryland, Baltimore, MD
*Purpose: Hepatic IRI represents a barrier to the use of available organs for transplant, particularly fatty livers. We aimed to discern the cellular subsets and…
2021 American Transplant Congress
Macrosteatosis in the US Pediatric Deceased Liver Donor Population, 2005-2018
J. Purvis, D. Dhall, C. McLeod, S. Sheikh, R. Cannon, K. Frey, J. Locke, B. Orandi
University of Alabama School of Medicine, Birmingham, AL
*Purpose: The pediatric obesity epidemic is associated with early signs of non-alcoholic fatty liver disease (NAFLD) such as increased hepatic macrosteatosis and liver enzymes. In…
2021 American Transplant Congress
Does the NSQIP-Transplant Experience Demonstrate That Obese Kidney Transplant Recipients are Still at Increased Risk for Surgical Site Infections?
H. C. Yaffe¹, A. K. Belli¹, J. R. Parekh², D. L. Sudan³, N. Elias⁴, K. D. Conzen⁵, D. P. Foley⁶, R. Hirose⁷, S. M. Greenstein¹
¹Surgery, Montefiore-Einstein Center for Transplantation, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, ²Surgery, University of California San Diego, San Diego, CA, ³Surgery, Division of Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC, ⁴Surgery, Transplant Surgery Division, Massachusetts General Hospital, Boston, MA, ⁵Surgery, Division of Transplant Surgery, University of Colorado Hospital, Aurora, CO, ⁶Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁷Surgery, University of California San Francisco, San Francisco, CA
*Purpose: The National Surgical Quality Improvement Program for Transplant (NSQIP-T) was designed to track surgical outcomes in adult liver and kidney transplants (KTX). The Pilot…
2021 American Transplant Congress
Association of Obesity and Early Post Kidney Transplantation Complications
V. Sandra, N. Sanichar, D. Tsapepas, K. L. King, J. Van Bever, K. Toma, A. Hussain, S. Mohan
Columbia University Irving Medical Center, New York, NY
*Purpose: Although the prevalence of obesity among kidney transplant recipients is rising, there continues to be reluctance to waitlist obese candidates. We sought to determine…
2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
M. Quante¹, J. Iske¹, D. Perkins², M. Alegre³, H. Zhou¹, A. Elkhal¹, S. G. Tullius¹
¹Department of Surgery, Brigham and Women's Hospital, Boston, MA, ²University of Illinois at Chicago, Chicago, IL, ³Department of Medicine, The University of Chicago, Chicago, IL
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…