Articles tagged "Obesity"

2021 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis by Single-nucleus Rna Sequencing
C. Kuscu¹, C. Kuscu¹, M. Akram², A. Shetty³, D. G. Maluf⁴, J. Eason¹, V. Mas⁵
¹Surgery, James D Eason Transplat Institute, Memphis, TN, ²Surgery, Center for Biomedical Informatics, Memphis, TN, ³Surgery, Institute for Genome Sciences, School of Medicine, Baltimore, MD, ⁴Surgery, Program in Transplantation University of Maryland, Baltimore, MD, ⁵Surgery, Division of Surgical Science University of Maryland, Baltimore, MD
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is characterized by metabolic syndrome and the accumulation of fat in the liver cells (hepatocytes) leading to inflammation and…
2021 American Transplant Congress
State-level Trend in the Prevalence of Non-alcoholic Steatohepatitis for Liver Transplant Candidates in the United States, 2001-2017
S. Chang¹, M. Wang¹, M. Pozo², D. Ladner², D. Borja-Cacho²
¹Washington University School of Medicine, Saint Louis, MO, ²Northwestern University, Chicago, IL
*Purpose: As variation in the prevalence of obesity across states continues to grow, the prevalence of nonalcoholic steatohepatitis (NASH) is also rising. However, little is…
2021 American Transplant Congress
Recent Trends and Outcomes of Liver Transplantation for Non-alcoholic Steatohepatitis versus Alcohol Liver Disease in the United States: Obesity Might be Protective
K. Okumura, I. Lee, H. Sogawa, G. Veillette, D. John, T. Diflo, R. Bodin, D. Wolf, S. Nishida
Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY
*Purpose: Nonalcoholic steatohepatitis (NASH) and alcohol liver disease (ALD) are rapidly growing indications for liver transplantation (LT). The recent trends and outcomes in NASH and…
2021 American Transplant Congress
Outcomes After Liver Transplantation With Steatotic Grafts: Redefining Acceptable Cutoffs for Moderately Steatotic Grafts
B. L. Da¹, J. Satiya², R. P. Heda³, Y. Jiang⁴, L. Lau⁵, A. Fahmy¹, A. Winnick¹, N. Roth¹, E. Grodstein¹, P. J. Thuluvath⁶, A. K. Singal⁷, T. D. Schiano⁸, L. W. Teperman¹, S. K. Satapathy¹
¹Liver Disease, Northwell Health, Manhasset, NY, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Tulane Medical Center, Memphis, TN, ⁴The University of Memphis, Memphis, TN, ⁵Northwell Health, Manhasset, NY, ⁶University of Maryland School of Medicine, Baltimore, MD, ⁷Liver Disease, Avera McKenna University Health Center and Transplant Institute, Manhasset, NY, ⁸Icahn School of Medicine at Mount Sinai, New York City, NY
*Purpose: Graft macro-steatosis can predispose to worse graft survival. Our objective was to redefine acceptable cutoffs for graft steatosis using the national database.*Methods: Data of…
2021 American Transplant Congress
The Role of Histone Acetylation/methylation Mediated Epigenetic Modifications in the Pathogenesis of Non-alcoholic Steatohepatitis-associated Liver Carcinogenesis
P. K. Rajan¹, U. Utibe-Abasi¹, J. D. Sanabria¹, M. Banerjee², G. Smith¹, M. S. Schade¹, J. Sanabria¹, K. Sodhi¹, S. Pierre², Z. Xie², J. I. Shapiro², J. Sanabria¹
¹Department of Surgery, Marshall University, Huntington, WV, ²Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, Huntington, WV
*Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers and is characterized by an acquisition of multiple abnormal phenotypes driven by epigenetic…
2021 American Transplant Congress
Obesity is Associated with Greater Gender Disparity in Access to Kidney Transplantation
S. S. Sheikh, B. Orandi, P. MacLennan, H. Qu, R. M. Cannon, D. Anderson, M. Hanaway, S. Mehta, V. Kumar, R. Reed, J. Locke
Surgery, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity and female gender have been associated with decreased access to kidney transplant. We sought to use contemporary data to examine the likelihood of…
2021 American Transplant Congress
Utilization of Pre-Procurement Donor Liver Biopsy in Donation-after-circulatory-Death Liver Transplantation
A. C. Bolognese¹, N. Neidlinger¹, C. Sparks², A. Schneider², A. M. D'Alessandro¹, D. P. Foley¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²UW Organ and Tissue Donation, Madison, WI
*Purpose: Careful selection of suitable DCD donor livers is critical to obtain optimal transplant outcomes. In order to identify potentially suitable livers prior to DCD…
2021 American Transplant Congress
Multistep Algorithm to Achieve Weight Loss Goal in Advanced Stage Obesity Kidney Transplant Candidates: A Single Center Preliminary Report
A. Shah, J. Galpern, L. Castaldo, P. Touhy, M. Thomas, A. Aaron, M. Fruscione, L. Dageforde, N. Elias
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Obesity causes and complicates glomerulonephritis and chronic kidney disease (CKD) leading to end stage renal disease (ESRD). Kidney Transplantation (KT) improves ESRD patients’ survival…
2021 American Transplant Congress
Liver Transplantation with Super Obese Donors (BMI≥50) Grafts: An Acceptable Pathway to Expand the Donor Pool. Analysis of the OPTN/UNOS Liver Transplant Registry
P. Vargas¹, C. Argo², H. Zachary², M. Stotts², N. Intagliata², P. Northup², J. Oberholzer¹, S. Pelletier¹, N. Goldaracena¹
¹Transplant Surgery, University of Virginia Health System, Charlottesville, VA, ²Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA
*Purpose: We aimed to analyze the impact of donor body mass index (BMI) on recipient morbidity and survival following liver transplantation (LT).*Methods: The UNOS-STAR database…
2021 American Transplant Congress
Cellular Landscape of Steatotic Livers Revealed by Single-nuclei Rna Sequencing
C. Kuscu¹, C. Kuscu¹, A. Shetty², E. Bardhi³, T. Rousselle⁴, J. Eason¹, M. Sraj⁵, D. Maluf⁶, V. Mas⁴
¹Surgery, James D Eason Transplant Institute, Memphis, TN, ²University of Maryland, Institute for Genome Sciences, Baltimore, MD, ³Program in Transplantation - University of Maryland, Baltimore, MD, ⁴Surgery, Division of Surgical Science, Baltimore, MD, ⁵Surgery, University of Maryland, Baltimore, MD, ⁶Surgery, Program in Transplantation - University of Maryland, Baltimore, MD
*Purpose: Hepatic IRI represents a barrier to the use of available organs for transplant, particularly fatty livers. We aimed to discern the cellular subsets and…