Articles tagged "Nuclear factor-kappa B (NF-kB)"

2017 American Transplant Congress
Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection.
H. Higuchi,^1,2 D. Iwami,¹ K. Hotta,¹ N. Shinohara,¹ M. Murakami.²
¹Hokkaido University, Renal and Genitourinary Surgery, Sapporo, Hokkaido, Japan; ²Hokkaido University, Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Sapporo, Hokkaido, Japan
[Introduction and Objective] Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by simultaneous activation of NFκB and STATs (IL-17, TNFα, and…
2016 American Transplant Congress
Inflammation Amplifier, a Chemokine Inducer in Non-Immune Cells in Kidney Transplantation Graft.
H. Higuchi,^1,2 H. Bando,² J. Jing-Jing,² T. Atsumi,² D. Iwami,¹ K. Morita,¹ N. Shinohara,¹ M. Murakami.²
¹Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Introduction: Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by the simultaneous activation of NFκB and STATs (IL-17, TNFα, and IL-6)…
2016 American Transplant Congress
The Fine-Tuning of CXCL8 Protects Kidney Against Ischemia-Reperfusion Injury in Mice Lacking MicroRNA-146a.
L. Amrouche,^1,2 G. Desbuissons,¹ M. Rabant,^1,2 C. Legendre,^1,2 F. Terzi,² D. Anglicheau.^1,2
¹U1151, INSERM, Paris, France, Metropolitan; ²Department of Kidney Transplantation, Necker hospital, Paris, France, Metropolitan.
Acute kidney injury leads to the development of tubular injury and interstitial inflammation that need to be controlled to avoid fibrosis development. We hypothesized that…
2016 American Transplant Congress
NFκB Inhibitor Withaferin A Blocks IBMIR In Vitro: miRNA 375 Analysis.
M. Kanak,¹ M. Takita,² G. Yoshimatsu,² M. Lawrence,² M. Levy,¹ B. Naziruddin.³
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Islet Tranpsplant Lab, Baylor Research Institute, Dallas, TX; ³Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Background: Instant Blood Mediated Inflammatory Reaction (IBMIR) has been shown to severely affect islet engraftment. We previously reported that Withaferin A (WA) can protect islets…
2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹
¹Western University, London, Canada; ²University of Southhampton, Southhampton, United Kingdom; ³Lakehead University, Thunder Bay, Canada; ⁴University of Gronigen, Groningen, Netherlands; ⁵University Hospital Bern, Bern, Switzerland.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…
2015 American Transplant Congress
Epigenetic Reprogramming of Murine Cytomegalovirus Immediate Early Genes Induced By Renal Transplantation
M. Hummel,¹ X.-F. Liu,¹ C. Jie,¹ Z. Zhang,¹ S. Yan,¹ J.-J. Wang,¹ S. Kurian,² D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Dept of Molecular and Experimental Medicine, The Scripps Research Institute, LaJolla, CA.
Background: Reactivation of latent CMV is a significant infectious complication in solid organ transplant recipients. MCMV is a valuable model for studying molecular mechanisms controlling…
2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
H. Ono,¹ Y. Asahi,¹ T. Yoshida,¹ Y. Koshizuka,¹ M. Watanabe,¹ U. Tomaru,² S. Emoto,¹ M. Fukai,³ A. Taketomi,¹ S. Todo,⁴ K. Yamashita.³
¹Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ²Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ⁴St Mary's Hospital, Kurume, Japan.
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
2015 American Transplant Congress
Endosome-Based Activation of Non-Canonical NF-kB Signaling By Membrane Attack Complexes
D. Jane-wit,¹ Y. Surovtseva,² L. Qin,³ P. Clark,⁴ T. Manes,⁴ M. Kashgarian,⁵ N. Kirkiles-Smith,⁴ R. Liu,⁴ C. Wang,⁴ G. Tellides,³ J. Pober.⁴
¹Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT; ²Yale Center for Molecular Discovery, Yale University School of Medicine, New Haven, CT; ³Department of Surgery, Yale University School of Medicine, New Haven, CT; ⁴Department of Immunobiology, Yale University School of Medicine, New Haven, CT; ⁵Department of Pathology, Yale University School of Medicine, New Haven, CT.
Using sera from transplant patients with high-titer panel reactive antibody (PRA), we previously described a model for studying the effects of alloantibody binding and complement…