ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "non-heart-beating"

  • 2017 American Transplant Congress

    Normothermic Regional Perfusion of Donors Following Circulatory Death Improves Outcomes in Liver Transplantation.

    E. Mowlem,1 L. Randle,2 C. Fear,1 K. Crick,1 S. Messer,4 S. Large,4 A. Butler,3 C. Watson.3

    1Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom; 2OrganOx Ltd, Oxford, United Kingdom; 3Dept of Surgery, University of Cambridge, Cambridge, United Kingdom; 4Papworth Hospital, Cambridge, United Kingdom

    Introduction: Donation after Circulatory Death (DCD) provides 23% of UK livers for transplantation, but such transplants are associated with more primary graft function and early…
  • 2017 American Transplant Congress

    The Performance of Four Tools for the Prediction of Potential for Organ Donation After Cardiac Death in Neurocritical Patients: A Prospective, Multicenter, Observational Study.

    Z. Guo,1 G. Xu,1 P. Schroder,2 M. Manyalich,3 X. He,1 G. Chen.1

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 2Department of Surgery, Duke University Medical Center, Durham; 3Transplant Procurement Management-Donation & Transplantation institute Foundation, Barcelona, Spain

    Background Successful donation after circulatory death (DCD) requires identification of patients dieing within limited time after withdrawal of life-sustaining treatment (WLST). We aimed to compare…
  • 2017 American Transplant Congress

    A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.

    M. Xu,1 B. Banan,1 X. Wang,1 D. Chirumbole,1 B. Rabe,1 S. Garcia-Aroz,1 D. Nayak,1 Z. Zhang,1 J. Jia,1 G. Upadhya,1 J. Gaut,2 P. Manning,3 Y. Lin,1 W. Chapman.1

    1Department of Surgery, Washington University School of Medicine, St. Louis; 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; 3Tioma Therapeutics, Inc, St. Louis

    PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
  • 2017 American Transplant Congress

    A Novel Technique to Increase Donor Utilization: Our Experience Using High-Dose Tissue Plasminogen Activator Flush in Donation-After-Cardiac-Death Donors for Liver Transplantation.

    J. Graham, K. Lorenzen, S. Bellemare, M. Kinkhabwala, J. Rocca.

    Surgery, Montefiore Medical Center, Bronx, NY

    The utilization of donation-after-cardiac-death (DCD) livers remains generally low. Strategies to address the perceived liabilities associated with DCD organs could influence their utilization in a…
  • 2017 American Transplant Congress

    CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation After Cardiac Death Rat Kidney Transplantation.

    X. Wang,1 M. Xu,1 J. Jia,1 Z. Zhang,1 J. Gaut,2 G. Upadhya,1 P. Manning,3 Y. Lin,1 W. Chapman.1

    1Department of Surgery, Washington University School of Medicine, Saint Louis; 2Pathology and Immunology, Washington University School of Medicine, Saint Louis; 3Tioma Therapeutics, Saint Louis

    Purpose: We evaluated the potential effects of antibody-mediated CD47 blockade to modulate vascular endothelial nitric oxide activity and reduce ischemia reperfusion injury in a rat…
  • 2017 American Transplant Congress

    Implementing a Successful DCD Heart Programme to the United Kingdom.

    M. Ryan, S. Duncalf.

    Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom

    The UK has the most successful DCD heart programme in the world which has primarily been developed in one region in England. Due to a…
  • 2017 American Transplant Congress

    Donor Warm Ischemic Time >80min Is an Important Predictor of Kidney Graft Survival from Donors After Cardiac Death.

    J. Chen,1 D. Mikhail,2 H. Sharma,3 A. Hijazi,1 D. Nap,1 L. Stitt,4 J. Jevnikar,5 M. Cooper,6 P. Luke,2 A. Sener.2

    1Schulich School of Medicine & Dentistry, London, Canada; 2Urology, Western University, London, Canada; 3General Surgery, Western University, London, Canada; 4LW Stitt Statistical Services, London, Canada; 5Engineering, Ryerson University, Toronto, Canada; 6Georgetown University, Washington

    We analyzed UNOS data to determine how donor warm ischemic time (WIT), donor BMI, donor hypertension (dHTN), cold ischemic time (CIT), and vasopressin use in…
  • 2017 American Transplant Congress

    Waitlist Outcomes of Patients Re-Listed Following Failed Donation After Cardiac Death (DCD) Liver Transplant.

    K. Croome, D. Lee, A. Keaveny, C. Taner.

    Transplant, Mayo Clinic Florida, Jacksonville, FL

    Introduction: The outcome for patients re-listed after developing ischemic cholangiopathy(IC) or graft failure following liver transplant(LT) from a DCD donor, remains a significant concern. Better…
  • 2017 American Transplant Congress

    Single Kidney Transplantation from DCD Maastricht Category 3 Donors ≥ 60 Years: Is It Safe?

    E. Favi,1 C. Puliatti,2 M. Ferraresso,1 S. Iesari,3 R. Cacciola.2

    1Renal Transplant, Ospedale Maggiore Policlinico, Milan, Italy; 2Renal Transplantation, The Royal London Hospital, London, United Kingdom; 3Organ Transplant, Presidio Ospedaliero S. Salvatore, L'Aquila, Italy

    Aim. Compared to DBD, DCD kidneys show higher rates of primary non function (PNF), DGF, rejection, and premature transplant (Tx) loss. Some authors have advised…
  • 2017 American Transplant Congress

    National Trends in Utilization of Donation After Cardiac Death Donor Livers for Transplantation.

    S. Kubal,1 R. Mangus,1 B. Ekser,1 R. Amos,2 J. Fridell.1

    1Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; 2Indiana Donor Network, Indianapolis, IN

    Background: Optimizing utilization of donation after cardiac death (DCD) livers is imperative to address organ shortage. Understanding factors that contribute to DCD liver discards is…
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