Articles tagged "non-heart-beating"

2015 American Transplant Congress
Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function
E. Ablorsu,¹ S. Zouwail,² P. Laftsidis,¹ B. Cook,¹ L. Szabo.¹
¹Cardiff Transplant Unit, University Hospital for Wales, Cardiff, United Kingdom; ²The Medical Biochemistry and Immunology Department, University Hospital for Wales, Cardiff, United Kingdom.
Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
2015 American Transplant Congress
CHBP in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia Reperfusion Injury in Isolated Porcine Kidneys
C. Yang,¹ S. Hosgood,² H. Carly,² P. Meeta,² Y. Long,³ T. Zhu,¹ M. Nicholson,² B. Yang.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, China; ³Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. There is an imperative need to better preserve isolated organs before transplantation. A non-erythropoiesis cyclic helix B peptide (CHBP) derived from erythropoietin was newly…
2015 American Transplant Congress
Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial
K. Woodside,¹ D. Goldfarb,² J. Rabets,² E. Sanchez,¹ D. Lebovitz,³ J. Schulak,¹ J. Fung,² B. Eghtesad.²
¹Transplant Institute, University Hospitals Case Medical Center, Cleveland, OH; ²Transplant Center, Cleveland Clinic, Cleveland, OH; ³LIfebanc, Cleveland, OH.
Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…
2015 American Transplant Congress
The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation
R. Johns,^1,2 M. Laftsidis,² E. Burrows,² F. Edwards,² E. Ablorsu,² P. James,¹ A. Phillips,^1,2 A. Asderakis.²
¹University of Cardiff, Cardiff, United Kingdom; ²University Hospital of Wales, Cardiff, United Kingdom.
IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
2015 American Transplant Congress
Expanding the Donor Pool: Comparison of Outcomes in DCD Vs Living Donor Liver Transplantation
G. Sapisochin,¹ J. Seal,² N. Goldaracena,¹ T. Reichman,² J. Laurence,¹ H. Bohorquez,² I. McGilvray,¹ D. Bruce,² P. Greig,¹ I. Carmody,² M. Cattral,¹ A. Ghanekar,¹ D. Grant,¹ G. Loss,² M. Selzner.¹
¹Department of Surgery, Toronto General Hospital. University of Toronto, Toronto, ON, Canada; ²Multi-Organ Transplant Institute, Ochner Medican Center, New Orleans, LA.
Living donors (LD) and donation after-circulatory-death (DCD) grafts represent important opportunities to increase the donor pool. We reviewed the combined experience at Toronto General Hospital…
2015 American Transplant Congress
Calcineurin Inhibitors (CNI) Minimization Associated With Mammalian Target of Rapamycin Inhibitors (i-mTOR) to Improve Renal Function in Renal Grafts from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
M. Molina,¹ E. Gutierrez,¹ S. González-Sanchidrian,² E. González,¹ J. Cabrera,¹ N. Polanco,¹ A. Hernández,¹ A. Sevillano,¹ M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital 12 de Octubre, Madrid, Spain; ²Nephrology, Hospital San Pedro de Alcántara, Caceres, Spain.
INTRODUCTION: Ischemia injury in kidneys grafts from UDCDD could produce a poor renal function. Minimized blood levels of CNI associated with i-mTOR therapy could avoid…