ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Neutrophils"

  • 2018 American Transplant Congress

    Extracellular Vesicles Derived from Huc-MSCs Alleviate Rat Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Neutrophil Inflammatory Response

    J. Yao,1,2 J. Cai,1,2 J. Zheng,1,2 L. Chen,1,2 Y. Zhang,1,2 Y. Yang.1,2

    1Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Guangzhou, Guangdong, China; 2Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .

    Mesenchymal stem cells (MSCs) have been reported possessing therapeutic effects on immunoregulation, tissue repair and regeneration from bench to bedside. Extracellular vesicles (EVs) derived from…
  • 2017 American Transplant Congress

    Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.

    T. Brennan, L. Lin, J. Pollara.

    Surgery, Duke University, Durham, NC

    Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…
  • 2017 American Transplant Congress

    Prognostic Significance of Preoperative Neutrophil-Lymphocyte Ratio in Patients Undergoing Liver Transplantation with Hepatocellular Carcinoma within Milan Criteria.

    S.-K. Kwon,1 J. Lee,1 S. Song,1 J. Lee,1 D. Kim,1 J. Lee,2 M. Kim,1 G. Choi,1 J. Choi,1 D. Han,1 S. Kim,1 D. Joo.1

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2Department of Surgery, CHA University, Bundang, Korea

    Introduction: The systemic inflammation biomarker, neutrophil-to-lymphocyte ratio (NLR) has been reported to be a predioctor of poor survival in patients with various cancers. The purpose…
  • 2017 American Transplant Congress

    Protective Effects of Bryostatin-1 on Neutrophil Migration in an In Vitro Model of Ischemia Reperfusion Injury: Impact for Therapy.

    F. Becker,1 L. Kebschull,1 T. Castor,3 D. Palmes,2 S. Alexander,2 F. Gavins.2

    1Department for General and Visceral Surgery, University Hospital Münster, Münster, Germany; 2Department of Molecular and Cellular Physiology, Department of Molecular and Cellular Physiology, Shreveport, LA; 3Aphios Corporation, Woburn, MA

    Background: Ischemia-reperfusion injury (IRI) is an inherent component of solid organ transplantation and axiomatically linked to graft damage. In the kidney, IRI results in a…
  • 2016 American Transplant Congress

    Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.

    A. Zarrinpar,1 T. Palumbo,1 K. Nakamura,1 C. Lassman,2 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
  • 2016 American Transplant Congress

    Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.

    B. Martinez Burgo,1 S. Ali,1 J. Kirby,1 N. Sheerin,1 S. Cobb,2 D. Kashanin.3

    1Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; 2Chemistry Department, Durham University, Durham, United Kingdom; 3Cellix Ltd., Dublin, Ireland.

    Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
  • 2016 American Transplant Congress

    Donor-Derived Monocytes Migrate to the Contralateral Lung and Cause Neutrophilia Following Single Lung Transplant.

    S. Chiu, Z. Zheng, H. Sun, M. DeCamp, Jr, G. Budinger, H. Perlman, A. Misharin, A. Bharat.

    Northwestern University, Chicago, IL.

    Purpose: Deterioration of the native lung from lung injury occurs in the majority of patients following single lung transplant, but its pathogenesis remains unknown. Here,…
  • 2016 American Transplant Congress

    Donor-Derived Toll-Like Receptor-Dependent Intravascular Monocytes Cause Primary Lung Graft Dysfunction.

    S. Chiu, Z. Zheng, H. Sun, M. DeCamp, Jr, G. Budinger, H. Perlman, A. Misharin, A. Bharat.

    Northwestern University, Chicago, IL.

    Purpose: Neutrophils mediate primary lung allograft dysfunction (PGD), the predominant cause of early graft loss following lung transplant. The mechanisms of neutrophil infiltration remain incompletely…
  • 2015 American Transplant Congress

    B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection

    M. Morita, D. Joyce, J. Fung, S. Qian, R. Fairchild, L. Lu.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Clevland Clinic, Cleveland, OH.

    The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…
  • 2015 American Transplant Congress

    Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury

    H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.

    Department of Surgery, University of Pittsburgh, Pittsburgh, PA.

    Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
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