ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Nephropathy"

  • 2022 American Transplant Congress

    Genotype and Phenotype Analysis and the Transplantation Strategy in Children with Uremia Caused by Nephronophthisis

    J. Li, H. Zhang, X. Su, J. Li, S. Wu, W. Wu, L. Ling, Q. Fu, C. Wu, L. Liu, C. Wang

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    *Purpose: Nephronophthisis- related ciliopathies(NPHP- RC), as an important cause of children's end-stage renal disease(ESRD), has strong genotype and phenotype heterogeneity, and the transplantation strategy of…
  • 2022 American Transplant Congress

    Multiplexed Droplet Single-Cell Sequencing (mux-seq) Identifies Novel Cell States in Renal Allograft Rejection

    P. Rashmi, S. Sur, T. Sigdel, P. Boada, M. Sarwal

    UCSF, San Francisco, CA

    *Purpose: Maintenance of systemic homeostasis by kidney requires the coordinated response of diverse cell types. Use of single-cell RNA sequencing (scRNAseq) for patient samples remains…
  • 2022 American Transplant Congress

    The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice

    D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit

    Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC

    *Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
  • 2022 American Transplant Congress

    Novel Drug Target Identified for Reversal of Renal Tubular Injury

    S. Sur, M. Kerwin, S. Pineda, M. Sarwal

    UCSF, San Francisco, CA

    *Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…
  • 2022 American Transplant Congress

    Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
  • 2022 American Transplant Congress

    RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy

    W. Yicun, W. Yuxuan, H. Xiaopeng

    Department of Urology, Beijing Chaoyang Hospital, Beijing, China

    *Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
  • 2022 American Transplant Congress

    Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection

    H. BAE1, J. Ryu2, J. Jang1, J. Lee1, G. Ko1, H. PARK1, E. Oh3

    1Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, 2Department of Laboratory Medicine, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, seoul, Korea, Republic of, 3Catholic University Department of Laboratory Medicine, Seoul 137-040, Korea, Republic of

    *Purpose: BK virus (BKV) infection is a common problem in kidney transplant recipients receiving immunosuppressive therapy, resulting in a serious complications including BKV-associated nephropathy and…
  • 2021 American Transplant Congress

    Leflunomide Therapy for Treatment of Bk Viremia in Pediatric Kidney Transplant Recipients

    A. Aldieri1, M. Chandran2, D. Matossian3, B. Magella4, D. Lazear4, M. Bock2, E. Blanchette2

    1Children's Hospital Colorado, Denver, CO, 2Children's Hospital Colorado, Aurora, CO, 3Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    *Purpose: BK viremia (BKV) after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy (BKVN) and impacts graft survival. Conventional treatment involves reduction of…
  • 2021 American Transplant Congress

    Oxalate Nephropathy After Kidney Transplant: Defining Histological Patterns, Contributing Factors and Graft Outcome

    N. Jakob1, A. Chuu1, J. Ninan1, E. Lim1, N. Zhang1, H. Amer2, F. Cosio2, H. Wadei3, M. Ryan1, C. Cortese3, L. Cornell2, M. Keddis1

    1Nephrology, Mayo Clinic, Scottsdale, AZ, 2Nephrology, Mayo Clinic, Rochester, MN, 3Nephrology, Mayo Clinic, Jacksonville, FL

    *Purpose: The objective of this study is to evaluate KTx recipients with biopsy proven oxalate nephropathy (ON) to better define risk factors, histologic patterns and…
  • 2021 American Transplant Congress

    Effect of Defibrotide on Kidney Ischemia Reperfusion Injury in a Preclinical Renal Transplant Model

    P. Pine1, Z. Sun2, A. Matas3, J. Shi1, A. Ebrahimnejad1, M. Zanette4, P. Halloran5, J. S. Bromberg6, R. Hanvesakul7

    1Jazz Pharmaceuticals, Palo Alto, CA, 2Johns Hopkins Medicine, Baltimore, MD, 3Univ of Minnesota, Minneapolis, MN, 4Jazz Pharmaceuticals, Philadelphia, PA, 5Univ of Alberta, Edmonton, AB, Canada, 6Univ of Maryland School of Medicine, Baltimore, MD, 7Jazz Pharmaceuticals, Oxford, United Kingdom

    *Purpose: Ischemia reperfusion injury (IRI) is a major contributor to graft failure. During organ removal and preservation, ischemia results in anaerobic respiration and cellular damage.…
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