Articles tagged "Necrosis"

2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
Necroptosis Is Involved in CD4⁺ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.
C. Kwok,^1,2 N. Montwill,^1,2 A. Pavlosky,^1,2 A. Haig,² X.-Y. Huang,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2,3
¹Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada; ²Department of Pathology and Laboratory Medicine, Western University, London, Canada; ³Department of Medicine, Western University, London, Canada.
Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
The Immunogenic Perlecan Fragment LG3 Is Released Through Apoptotic Extracellular Vesicles Downstream of Caspase-3 Activation
D. Beillevaire,¹ J. Turgeon,¹ D. Gingras,² é. Boilard,³ M. Dieudé,¹ M.-J. Hébert.¹
¹CNTRP, CRCHUM, Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³CNTRP, CHUL, Québec, Canada.
LG3, a C-terminal fragment of perlecan, has been implicated in aggravation of renal allograft rejection and vascular injury. LG3 is known to be produced at…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…