ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Natural killer cells"

  • 2020 American Transplant Congress

    Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection

    W. Zhang, S. Farouk, Z. Sun, W. Huang, Z. Yi, J. Fu, C. Wei, M. Fribourg-Casajuana, C. He, P. Cravedi, B. Murphy

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…
  • 2020 American Transplant Congress

    Adjuvant Immunotherapy for Liver Transplant Recipients with Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells

    M. Ohira1, R. Hotta1, Y. Imaoka1, K. Sato1, N. Tanimine1, H. Tahara1, K. Ide1, T. Kobayashi1, Y. Tanaka1, A. Tzakis2, S. Nishida2, H. Ohdan1

    1Hiroshima University, Hiroshima, Japan, 2University of Miami, Miami, FL

    *Purpose: Development of an effective adjuvant therapy to prevent HCC recurrence after liver transplantation (LT) is an important medical requirement. Immunosuppressive regimens currently used after…
  • 2020 American Transplant Congress

    Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients

    L. Zaffiri1, J. E. Messinger2, J. Yi2, K. J. Weinhold2, G. Ferrari2, M. Luftig2, S. M. Palmer1

    1Pulmonary and Critical Care, Duke University, Durham, NC, 2Duke University, Durham, NC

    *Purpose: After lung transplantation, Epstein-Barr virus (EBV) is a common opportunistic infection. The significance of EBV viremia following solid organ transplantation (SOT) remains unclear. Host…
  • 2020 American Transplant Congress

    Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury

    A. C. Dionne

    Microbiology and Immunology, Western University, London, ON, Canada

    *Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
  • 2019 American Transplant Congress

    Immune Cell Types and Host Gene Signatures Associated with Epstein-Barr Virus (EBV) Post-Transplant Lymphoproliferative Disorder (PTLD)

    J. Toh1, F. Vallania1, W. A. Haynes1, G. Bhagat2, F. E. Craig3, S. H. Swerdlow4, T. Tousseyn5, S. M. Krams1, P. Khatri1, O. M. Martinez1

    1Stanford University School of Medicine, Stanford, CA, 2Columbia University Medical Center, New York, NY, 3Mayo Clinic College of Medicine, Phoenix, AZ, 4University of Pittsburgh School of Medicine, Pittsburg, PA, 5Katholieke Universiteit Leuven, Leuven, Belgium

    *Purpose: PTLD is a serious post-transplant complication that encompasses a range of abnormal lymphoproliferations, including EBV+ B cell lymphomas. Although many are EBV-driven, a significant…
  • 2019 American Transplant Congress

    Adjuvant Immunotherapeutic Approach For Liver Transplant Recipients With Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells

    M. Ohira1, R. Hotta1, Y. Imaoka1, K. Sato1, Y. Tanaka1, A. G. Tzakis2, S. Nishida3, H. Ohdan1

    1Hiroshima University, Hiroshima, Japan, 2Cleveland Clinic Florida, Weston, FL, 3New York Medical College, Valhalla, NY

    *Purpose: Although liver transplantation (LT) is a preferred treatment for selected patients with Hepatocellular carcinoma (HCC), HCC-recurrence would be a still important medical problem. Most…
  • 2019 American Transplant Congress

    Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells

    J. F. Kuehne1, R. Ballmàs Sanz1, A. Hitz1, B. Wiegmann2, K. A. Bläsing1, F. Ius2, A. Knoefel2, I. Tudorache2, M. Avsar2, D. Jonigk3, A. Haverich2, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany, 3Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany

    *Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
  • 2019 American Transplant Congress

    Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death

    S. Balaji1, B. Fuhrmann2, D. Lian3, H. Diao3, S. Ma3, Z. Zhang3, A. M. Jevnikar3

    1Physiology, Western University, London, ON, Canada, 2Microbiology and Immunology, Western University, London, ON, Canada, 3London Health Sciences Centre, London, ON, Canada

    *Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
  • 2019 American Transplant Congress

    NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies

    J. Barnes1, F. Suliman2, A. Shammout1, E. A. Farkash1

    1Pathology, Michigan Medicine, Ann Arbor, MI, 2Nephrology, Michigan Medicine, Ann Arbor, MI

    *Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
  • 2019 American Transplant Congress

    CD56+CD57+ Infiltrate is a Predominant Subset of Infiltrating Natural Killer Cell in Renal Transplant Biopsies with Antibody-Mediated Rejection

    H. Jung1, Y. Wee2, J. Kim2, M. Choi2, J. Choi2, H. Kwon2, J. Jung2, S. Kim3, Y. Cho4, Y. Park4, H. Go4, M. Han5, Y. Kim2, D. Han2, S. Shin2

    1Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 2Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 3Department of Convergence Medicine, Asan Institute for life sciences, Asan Medical Center, Seoul, Korea, Republic of, 4Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 5Department of Clinical Epidemiology, Asan Medical Center, Seoul, Korea, Republic of

    *Purpose: To verify a subset of intragraft and circulating natural killer cells associated with kidney allograft rejection and fibrosis.*Methods: Thirty-nine clinically indicated transplant biopsies performed…
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