Articles tagged "Natural antibodies"

2019 American Transplant Congress
Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent
I. Adam¹, B. Motyka², L. West³
¹Medical Microbiology & Immunology, University of Alberta, Edmonton, AB, Canada, ²Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, Surgery, Immunology, Lab Medicine & Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…
2018 American Transplant Congress
Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis
K. Brayman,¹ P. Chhabra,¹ C. Wilson,² A. Marshall,² D. Moore.²
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN.
Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…
2018 American Transplant Congress
Serum Treatment with Fetal Bovine Serum Significantly Increases Luminex-Based HLA Antibody Assay Specificity by Reducing Heterophile Antibody Interference
A. Jaramillo,¹ J. House,¹ L. Nelson,¹ S. Stoll,¹ R. Ridgley,¹ H. Khamash.²
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ; ²Department of Medicine, Mayo Clinic, Phoenix, AZ.
Mean fluorescence intensity (MFI) values obtained from Luminex-based HLA antibody assays are used to determine the relative strength of HLA antibodies. However, MFI values can…
2017 American Transplant Congress
Generation of Natural Antibodies Post Transplant and Association with Kidney Allograft Loss.
S. See,¹ A. Loupy,² O. Aubert,² Y. Veras,¹ X. Lebreton,² B. Gao,³ C. Legendre,² D. Anglicheau,² E. Zorn.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²Department of Kidney Transplantation, Hopital Necker, Université Paris, René Descartes and APHP, Paris, France; ³The First Hospital of Jilin University, Changchun, China
The development of donor specific antibodies (DSA) reacting to mismatched donor class I and class II HLA is a prominent risk factor for kidney graft…
2017 American Transplant Congress
Elevated Circulating AT1R Levels Indicate Heightened Risk for Antibody Mediated Rejection and Graft Failure.
P. Kimball, G. Gupta, F. McDougan.
Transplant Surgery, VCUHealth Systems, Richmond, VA
Background.Antibody(Ab) against the angiotensin II receptor(AT1R) can cause antibody mediated rejection(AMR) and graft failure after transplantation. We evaluated whether circulating AT1R is a potential marker…
2016 American Transplant Congress
Prevalence of Polyreactive Innate-Like B Cells Among Graft-Infiltrating B Cells in Human Cardiac Allograft Vasculopathy.
D. Chatterjee,¹ C. Moore,² B. Gao,³ K. Clerkin,¹ S. See,¹ D. Shaked,¹ K. Rogers,¹ S. Nunez,¹ Y. Veras,¹ L. Addonizio,¹ M. Givertz,⁴ Y. Naka,¹ D. Mancini,¹ R. Vasilescu,⁵ C. Marboe,⁵ S. Restaino,¹ J. Madsen,² E. Zorn.¹
¹Medicine, Columbia University Medical Center, NY, NY; ²Massachusetts General Hospital Transplant Center, Boston; ³First Hospital of Jilin University, Changchun, China; ⁴Brigham and Women's Hospital, Boston; ⁵Pathology & Cell Biology, Columbia University Medical Center, NY.
Cardiac allograft vasculopathy (CAV) is a leading cause of death in long-term heart transplant survivors. Dense B cell infiltrates are common in heart transplants with…
2015 American Transplant Congress
Detection of Donor Specific HLA-Ab (DSA) Against Native HLA Molecules Expressed On Donor Cell Surface to Eliminate False Positive DSA in Luminex Single Antigen Beads (LMX-SAB)
G. Chen, L. Lin, D. Tyan.
Pathology, Stanford University, Palo Alto, CA.
Introduction:The LMX-SAB has been extensively used for DSA virtual crossmatch (VXM) to predict actual crossmatch (AXM). The extreme pH and harsh chemical reaction conditions used…