Articles tagged "Multicenter studies"

2017 American Transplant Congress
Donor-Derived Cell-Free DNA Is a Dynamic Biomarker of Active Rejection in Kidney Allografts.
D. Brennan,¹ J. Bromberg,² E. Poggio,³ D. Hiller,⁴ J. Sninsky,⁴ R. Woodward,⁴ J. Yee,⁴ R. Bloom.⁵
¹Washington University, St. Louis, MO; ²University of Maryland, Baltimore, MD; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) has shown promise as a biomarker in identification of allograft rejection. Here we report on the changes in dd-cfDNA prior…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2017 American Transplant Congress
Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants.
S. Min,¹ T. Daljevic,¹ O. Lee,¹ M.-E. Alary,⁶ F. Murdoch,⁵ R. Parekh,¹ V. Ng,¹ D. Hebert,¹ L. Hamiwka,² T. Blydt-Hansen,³ V. Phan,⁴ P. Birk,³ U. Allen,¹ S. Urschel,⁵ CNTRP POSITIVE Research Group, B. Foster,⁶ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Alberta Children's Hospital, Calgary, Canada; ³University of Winnipeg, Winnipeg, Canada; ⁴Université de Montréal, Motreal, Canada; ⁵Stollery Children's Hospital, Edmonton, Canada; ⁶McGill University, Montreal, Canada
PURPOSE: We characterized the evolution of out-of-range tacrolimus (TAC) concentrations and associated factors during 1 year following a pediatric solid organ transplant (SOT).METHODS: Heart, kidney…
2017 American Transplant Congress
Perceived Patient Barriers for Kidney Transplant Evalution Among Transplant Center Staff.
L. McPherson, K. Lipford, R. Hamoda, J. Gander, S. Pastan, R. Patzer.
Emory University, Atlanta, GA
Background: The Southeastern United States has the lowest rates of kidney transplant in the nation. Disparities in transplant access among end stage renal disease (ESRD)…
2017 American Transplant Congress
Hispanic Paradox in Patients with Liver Cirrhosis.
K. Atiemo, J. Caicedo, D. Ganger, E. Gordon, L. Zhao, S. Montag, H. Maddur, L. VanWagner, L. Kulik, S. Flamm, S. Goel, A. Kho, R. Kang, M. Abecassis, D. Ladner.
Northwestern University Transplant Research Collaborative, Chicago
IntroductionA paradoxical survival advantage for Hispanics compared to non-Hispanic whites (NHW) has been well described for many clinical conditions e.g diabetes however, with respect to…
2017 American Transplant Congress
Racial Differences in Liver Cirrhosis-Related Mortality Among Patients with Model for End-Stage Liver Disease Sodium Score (MELDNa) ≤ 15.
K. Atiemo,¹ H. Maddur,¹ L. Zhao,¹ A. Skaro,² S. Montag,¹ L. VanWagner,¹ S. Goel,¹ A. Kho,¹ R. Kang,¹ J. Holl,¹ M. Abecassis,¹ J. Levitsky,¹ L. Kulik,¹ D. Ladner.¹
¹Northwestern University Transplant Research Collaborative, Chicago; ²London Health Sciences Center, London, ON, Canada
Introduction:Subpopulations of patients with liver cirrhosis exist for whom the Model for End-Stage Liver Disease Sodium Score (MELDNa) is suboptimal for mortality prediction and who…
2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
E. Berglund,¹ M. Andersen Ljungdahl,¹ D. Bogdanovic,¹ D. Berglund,³ J. Wadström,¹ A. Weissenbacher,² P. Petruzzo,⁴ S. Schneeberger.²
¹Karolinsk Institutet, Dpt of Clinical Science, Intervention, and Technology, Stockholm, Sweden; ²Innsbruck Medical University, Center for Operative Medicine, Innsbruck, Austria; ³Uppsala University, Dpt of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala, Sweden; ⁴Edouard Herriot Hospital, Dpt of Transplantation, Lyon, France
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…
2017 American Transplant Congress
Extraction Time During Liver Retrieval Impairs Survival After Transplantation.
I. Jochmans,¹ S. Fieuws,² I. Tieken,³ U. Samuel,³ J. Pirenne.¹
¹Abdominal Transplantation, UZ Leuven, Leuven, Belgium; ²ICBSB, UZ Leuven, Leuven, Belgium; ³Eurotransplant, Leiden, Netherlands
During donor hepatectomy, despite topic cooling to 10-20[deg]C, the liver still sustains warm ischemia that might be harmful.We investigated the relationship between extraction time (ET)…
2016 American Transplant Congress
Center Level Analysis of Changes in Living Donor Transplant Rates in the United States.
D. Keith, A. Nishio Lucar, G. Vranic.
Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA.
Rates of living donor kidney transplantation have been declining in the United States since 2003. Tremendous variation exists in the rate of living donor transplantation…
2016 American Transplant Congress
Arterial Hypertension After Renal Transplantation in Pediatric Patients: An Analysis of CERTAIN Registry.
R. Sugianto,¹ E. Wühl,² B. Schmidt,¹ K. Krupka,² B. Höcker,² B. Tönshoff,² A. Melk.¹
¹Children's Hospital, Hannover Medical School, Hanover, Germany; ²Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany.
BackgroundOur study aimed to describe the prevalence of hypertension & blood pressure (BP) control as well as influencing factors in pediatric renal transplant patients.MethodCasual BP…