Articles tagged "Multicenter studies"

2017 American Transplant Congress
Racial Differences in Liver Cirrhosis-Related Mortality Among Patients with Model for End-Stage Liver Disease Sodium Score (MELDNa) ≤ 15.
K. Atiemo,¹ H. Maddur,¹ L. Zhao,¹ A. Skaro,² S. Montag,¹ L. VanWagner,¹ S. Goel,¹ A. Kho,¹ R. Kang,¹ J. Holl,¹ M. Abecassis,¹ J. Levitsky,¹ L. Kulik,¹ D. Ladner.¹
¹Northwestern University Transplant Research Collaborative, Chicago; ²London Health Sciences Center, London, ON, Canada
Introduction:Subpopulations of patients with liver cirrhosis exist for whom the Model for End-Stage Liver Disease Sodium Score (MELDNa) is suboptimal for mortality prediction and who…
2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
E. Berglund,¹ M. Andersen Ljungdahl,¹ D. Bogdanovic,¹ D. Berglund,³ J. Wadström,¹ A. Weissenbacher,² P. Petruzzo,⁴ S. Schneeberger.²
¹Karolinsk Institutet, Dpt of Clinical Science, Intervention, and Technology, Stockholm, Sweden; ²Innsbruck Medical University, Center for Operative Medicine, Innsbruck, Austria; ³Uppsala University, Dpt of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala, Sweden; ⁴Edouard Herriot Hospital, Dpt of Transplantation, Lyon, France
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…
2017 American Transplant Congress
Extraction Time During Liver Retrieval Impairs Survival After Transplantation.
I. Jochmans,¹ S. Fieuws,² I. Tieken,³ U. Samuel,³ J. Pirenne.¹
¹Abdominal Transplantation, UZ Leuven, Leuven, Belgium; ²ICBSB, UZ Leuven, Leuven, Belgium; ³Eurotransplant, Leiden, Netherlands
During donor hepatectomy, despite topic cooling to 10-20[deg]C, the liver still sustains warm ischemia that might be harmful.We investigated the relationship between extraction time (ET)…
2017 American Transplant Congress
Desensitization versus Deceased Donor Kidney Transplantation: What to Choose When Both Become Available?
B. Orandi,¹ X. Luo,² J. Garonzik-Wang,² R. Montgomery,³ D. Segev.²
¹UCSF, San Francisco; ²Johns Hopkins, Baltimore; ³NYU, New York
Kidney allocation system changes have improved deceased donor kidney transplant (DDKT) access for highly sensitized patients. For patients with a willing live donor but requiring…
2017 American Transplant Congress
Detection of Shared and Distinct Gene Expression Signatures in Tissue and Urine During Acute Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Chen,² K. Newell,³ P. Heeger,⁴ R. Mannon,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Department of Surgery, Emory University, Atlanta, GA; ⁴Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY
A major goal of the Clinical Trials in Organ Transplantation (CTOT) studies is the identification of biomarkers that predict or diagnose acute graft rejection in…
2017 American Transplant Congress
Immunosuppression and Graft Rejection in Living-Related HLA-Identical Renal Transplantation.
R. Ossman,¹ M. Jamme,¹ P. Galichon,¹ A. Hertig,¹ B. Moulin,² C. Legendre,³ E. Morelon,⁴ J.-L. Taupin,⁵ L. Rostaing,⁶ E. Rondeau.¹
¹Urgences Néphrologiques et Transplantation, Hôpital Tenon, RADOVFULL Study Group, Université Pierre et Marie Curie, Paris, France; ²Néphrologie et Transplantation, Hôpital Civil, Strasbourg, France; ³Néphrologie et Transplantation, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France; ⁴Néphrologie et Transplantation, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; ⁵Laboratoire d'Histocompatibilité, Hôpital Saint-Louis, Université Paris Diderot, Paris, France; ⁶Néphrologie et Transplantation d'Organes, Université Paul Sabatier, Toulouse, France
Purpose: We aimed to describe the immunosuppressive regimens and graft rejection rates in living-related HLA-identical (LR HLAid) renal transplantation.Methods: We performed a retrospective multicenter analysis…
2017 American Transplant Congress
Transplantation of Organs from Donors with Hepatitis C: The Potential to Substantially Increase Transplant Activity.
P. Trotter,^1,2 M. Robb,² I. Ushiro-Lumb,² J. Powell,³ C. Watson,¹ J. Bradley,¹ J. Neuberger.^2,4
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom; ³Hepatic-Pancreatico-Biliary Surgical Services and Edinburgh Transplant Unit, Royal Infirmary Edinburgh, Edinburgh, United Kingdom; ⁴The Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction. Organs from hepatitis C virus positive (HCV+ve) donors are commonly declined for transplantation because of the risk of disease transmission, but new direct acting…
2017 American Transplant Congress
Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.
V. Ferreira,¹ A. Humar,¹ E. Cordero,² E. Blumberg,³ S. Husain,¹ J. Kalpoe,⁴ M. Multicenter Influenza Group, D. Kumar.¹
¹UHN, Toronto, Canada; ²REIPI, Seville, Spain; ³UPenn, Philadelphia; ⁴LUMC, Leiden, Netherlands
Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…
2016 American Transplant Congress
Hospital Readmissions Following Incompatible Kidney Transplantation: A Multi-Center Study.
B. Orandi, E. King, X. Luo, S. Bae, B. Lonze, R. Montgomery, D. Segev.
Johns Hopkins, Baltimore.
Desensitization and incompatible live donor kidney transplantation (ILDKT) has improved survival vs. forgoing transplant or waiting for a compatible one. It is unknown if increased…
2016 American Transplant Congress
Young, Caucasian, Better Educated and Less Socially Deprived Patients Are More Likely to Be Transplanted with a Living Donor Kidney in the UK.
D. Wu,¹ M. Robb,² C. Watson,³ R. Ravanan,⁴ J. Forsythe,¹ W. Metcalfe,¹ C. Dudley,⁴ C. Bradley,⁵ H. Draper,⁶ A. Bradley,³ G. Oniscu.¹
¹Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; ²NHSBT, Bristol, United Kingdom; ³University of Cambridge, Cambridge, United Kingdom; ⁴Southmead Hospital, Bristol, United Kingdom; ⁵University of London, London, United Kingdom; ⁶University of Birmingham, Birmingham, United Kingdom.
IntroductionLiving donor kidney transplantation (LDKT) has significant benefits over deceased donor kidney transplantation (DDKT) in terms of improved survival and timely access to transplant. There…