Articles tagged "Multicenter studies"

2017 American Transplant Congress
Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study.
N. Law,¹ B. Hamandi,¹ C. Fegbeutel,² F. Silveira,³ E. Verschuuren,⁴ P. Ussetti,⁵ P. Chin-Hong,⁶ A. Solé,⁷ C.-L. Holmes-Liew,⁸ E. Billaud,⁹ P. Grossi,¹⁰ O. Manuel,¹¹ D. Levine,¹² R. Barbers,¹³ D. Hadjiliadis,¹⁴ L. Singer,¹ S. Husain.¹
¹University Health Network, Toronto, ON, Canada; ²Hannover Medical School, Hannover, Germany; ³University of Pittsburgh, Pittsburgh, PA; ⁴University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ⁵Hospital Puerta de Hierro, Madrid, Spain; ⁶University of California, San Francisco, CA; ⁷University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain; ⁸Royal Adelaide Hospital, Adelaide, Australia; ⁹APHP Hopital Européen G Pompidou, Paris, France; ¹⁰University of Insubria, Varese, Italy; ¹¹University Hospital of Lausanne, Lausanne, Switzerland; ¹²University of Texas Health Science Center San Antonio, San Antonio, TX; ¹³KECK Medical Center of University of Southern California, Los Angeles, CA; ¹⁴University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA
Introduction:Bronchiolitis obliterates syndrome (BOS) is a major impediment in the long term survival of LTRs. The main objective of this study was to identify infectious…
2017 American Transplant Congress
Results of the Initial Phase of the Portable Organ Care System (OCS™) Liver PROTECT Pivotal Trial.
J. Markmann,¹ M. Ghobrial,³ J. Magliocca,⁴ A. Demetris,⁵ M. Abouljoud.²
¹Department of Surgery-Division of Transplantation, Massachusetts General Hospital, Boston, MA; ²Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ³Sherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, TX; ⁴Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
PurposeThe OCS Liver PROTECT Trial is a prospective, international, randomized controlled trial to evaluate the impact of using portable ex-vivo warm, oxygenated blood perfusion using…
2017 American Transplant Congress
The TAKE-IT Intervention Improves Medication Adherence in Adolescent Kidney Transplant Recipients.
B. Foster,¹ A. Pai,² S. Furth,³ TAKE-IT Investigators.
¹McGill University, Montreal, Canada; ²Cincinnati Children's Hospital Medical Center, Cincinnati; ³Children's Hospital of Philadelphia, Philadelphia
Poor adherence to immunosuppressive medications limits renal allograft survival. This randomized controlled trial, evaluated whether young kidney transplant recipients administered a behavioral intervention showed greater…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Correlates with Antibody-Mediated Rejection in Kidney Allografts.
R. Bloom,¹ J. Bromberg,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Sninsky,⁴ J. Yee,⁴ D. Brennan.⁵
¹University of Pennsylvania, Philadelphia, PA; ²University of Maryland, Baltimore, MD; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵Washington University, St. Louis, MO
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of allograft rejection and…
2017 American Transplant Congress
U.S. Outcomes in Early Liver Transplantation for Alcoholic Hepatitis: Results from the American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH).
B. Lee,¹ N. Mehta,¹ L. Platt,² G. Im,³ G. Therapondos,⁴ H. Han,⁵ D. Victor,⁶ D. Dronamraju,⁷ I. Hanouneh,⁸ M. Voigt,⁹ M. Rinella,¹⁰ S. Eswaran,¹¹ J. Hause,¹¹ C. Hsu,¹² J. Dodge,¹ Z. Li,² N. Terrault.¹
¹UCSF, SF; ²Johns Hopkins, Baltimore; ³Mt Sinai, NYC; ⁴Ochsner, New Orleans; ⁵USC, LA; ⁶Houston Methodist, Houston; ⁷Maryland, Baltimore; ⁸Cleveland Clinic, Cleveland; ⁹Iowa, Iowa City; ¹⁰Northwestern, Chicago; ¹¹Rush, Chicago; ¹²UPenn, Philadelphia
INTRODUCTIONA Franco-Belgian protocol showed that early liver transplant (LT) in severe alcoholic hepatitis (AH) could improve survival with low incidence of alcohol relapse (AR). Application…
2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.
KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Is a Dynamic Biomarker of Active Rejection in Kidney Allografts.
D. Brennan,¹ J. Bromberg,² E. Poggio,³ D. Hiller,⁴ J. Sninsky,⁴ R. Woodward,⁴ J. Yee,⁴ R. Bloom.⁵
¹Washington University, St. Louis, MO; ²University of Maryland, Baltimore, MD; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) has shown promise as a biomarker in identification of allograft rejection. Here we report on the changes in dd-cfDNA prior…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2016 American Transplant Congress
Factors Associated with Mortality Among a Large Population of Patients with Cirrhosis and a Low MELD (<15).
K. Atiemo, L. Zhao, A. Skaro, L. VanWagner, S. Goel, A. Kho, B. Ho, R. Kang, S. Montag, J. Holl, M. Abecassis, D. Ladner.
Northwestern University, Chicago.
AimStudies suggest that certain patients with liver cirrhosis and a low MELD score (<15) remain at high risk for mortality. Current data is largely limited…
2016 American Transplant Congress
Impact on Renal Function of Stepwise Withdrawal of Tacrolimus Combined with Everolimus and EC-MPS vs Standard Treatment Combining Tacrolimus and EC-MPS in De Novo Liver Transplant Recipients: Results of the SIMCER Study.
F. Saliba,¹ C. Duvoux,² S. Dharancy,³ J. Dumortier,⁴ Y. Calmus,⁵ F. Di Giambattista,⁶ F. Conti.⁵
¹Hôpital Paul Brousse, Villejuif, France; ²Hôpital Henri Mondor, Créteil, France; ³Hôpital Claude Huriez, Lille, France; ⁴Hôpital Edouard Herriot, Lyon, France; ⁵Hôpital La Pitié-Salpêtrière, Paris, France; ⁶Novartis Pharma SAS, Rueil-Malmaison, France.
Introduction: Long-term post-liver transplant (LTx) complications, particularly impaired renal function (RF) and its consequences, remain a concern. Presented here are the results of the SIMCER…