Articles tagged "Multicenter studies"

2022 American Transplant Congress
Technology Enabled And Molecular Monitoring Of The Allograft And Transplant Recipient Study
N. Sulejmani¹, D. Axelrod², S. Dholakia¹, S. Shah³
¹CareDx, South San Francisco, CA, ²University of Iowa, Iowa City, IA, ³University of Cincinnati, Cincinnati, OH
*Purpose: With the widespread availability of smart mobile devices, mobile health (mHealth) provides the opportunity to reach wide array of patients. Readmission rates as high…
2022 American Transplant Congress
A Novel Prospective Validation Trial Of Multiple Blood-based RNA Signature Assays Pre And Post Kidney Transplant To Predict Rejection
L. Gallon¹, P. O'Connell², A. Chang³, M. Donovan⁴
¹Northwestern Univ, Chicago, IL, ²Westmead Inst, Sydney, Australia, ³Univ of Chicago, Chicago, IL, ⁴Verici Dx, Franklin, TN
*Purpose: The accuracy and utility of clinically defined and analytically validated predictive biomarkers in kidney transplantation is limited. We leveraged prior feasibility blood-RNA studies to…
2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³UMontreal, Montreal, QC, Canada, ⁴StMH, Toronto, ON, Canada, ⁵Laval U, Quebec, QC, Canada, ⁶UCalgary, Calgary, AB, Canada, ⁷USaskatchewan, Saskatoon, SK, Canada, ⁸HMR, Montreal, QC, Canada, ⁹McGill U, Montreal, QC, Canada, ¹⁰SCH, Edmonton, AB, Canada
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…
2022 American Transplant Congress
Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Practice Patterns, Report from the Paramour “Pediatric Renal AMR Outcomes” Study
N. Hayde¹, K. Twombley², I. Ashoor³, R. Engen⁴, L. Harshman⁵, R. Zahr⁶, C. Peterson⁷, S. McEwen⁸, A. Jain⁹, R. Garro¹⁰, M. Kallash¹¹, A. Mansuri¹², D. Puliyanda¹³
¹Montefiore Medical Center, Bronx, NY, ²Medical University of South Carolina, Charleston, SC, ³LCMCHealth, New Orleans, LA, ⁴Pediatrics, University of Wisconsin Madison, Madison, WI, ⁵University of Iowa Children's Hospital, Iowa City, IA, ⁶Le Bonheur Children's Hospital, Nashville, TN, ⁷University of Utah, Salt Lake City, UT, ⁸University of Minnesota, Minneapolis, MN, ⁹Wayne State, Troy, MI, ¹⁰Emory Universtiy, Atlanta, GA, ¹¹The Ohio State, Columbus, OH, ¹²Augusta University Medical Center, Augusta, GA, ¹³Cedars-Sinai Med Ctr, West Hollywood, CA
*Purpose: There is insufficient data on children with AMR in the literature, and the optimal therapy for AMR is not well defined. We aim to…
2022 American Transplant Congress
Associated Factors to Physical Inactivity of Kidney Transplant Patients: Subproject of ADHERE Brazil Multicenter Study
E. S. Sertorio¹, F. A. Colugnati¹, K. Denhaerynck², S. De Smet³, J. O. Medina⁴, M. M. Reboredo⁵, S. De Geest², H. Sanders-Pinheiro¹, T. ADHERE BRAZIL Study team¹
¹Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Brazil, ²Department of Public Health, Institute of Nursing Science, University of Basel, Basel, Switzerland, ³Transplant Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ⁴Nephrology, Hsopital do Rim, Federal University of São Paulo, São Paulo, Brazil, ⁵Pneumology, Federal University of Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Even though regular physical activity is a current recommendation for kidney transplant recipients (KTR), results from ADHERE Brazil study revealed a high prevalence of…
2022 American Transplant Congress
BMI Trajectory and Attributable Risk of New Onset Hypertension Among Obese Living Kidney Donors
R. D. Reed¹, M. C. McLeod¹, P. A. MacLennan¹, V. Kumar¹, S. E. Brooks¹, A. G. Maynor¹, L. A. Stanford¹, G. A. Baker¹, C. A. Schinstock², J. R. Silkensen³, G. R. Roll⁴, D. L. Segev⁵, B. J. Orandi¹, C. E. Lewis⁶, J. E. Locke¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Medicine, Hennepin County Medical Center, Minneapolis, MN, ⁴Surgery, University of California San Francisco, San Francisco, CA, ⁵Surgery, Johns Hopkins University, Baltimore, MD, ⁶Epidemiology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity increases hypertension risk in general and living kidney donor populations. Risk attributable to donation in the context of obesity and whether that risk…
2022 American Transplant Congress
Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared with One or Two Dose Vaccinated Solid Organ Transplant Recipients: A Multicenter, Matched Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Ramesh Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, J. Matelski², A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³Department of Medicine, UMontreal, Montreal, QC, Canada, ⁴Kidney Transplant Program, St. Michael's Hospital, Toronto, ON, Canada, ⁵Transplantation Unit, Renal division, Laval University, Quebec, QC, Canada, ⁶Division of Transplant Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Center of Saskatchewan, Saskatoon, SK, Canada, ⁸Hôpital Maisonneuve-Rosemont Research Institute, Montreal, QC, Canada, ⁹McGill University, Montreal, QC, Canada, ¹⁰Stollery Children's Hospital, Edmonton, AB, Canada
*Purpose: It is unknown if vaccine breakthrough COVID-19 infections are milder or as severe as infections in unvaccinated solid organ transplant (SOT) recipients.*Methods: We performed…
2022 American Transplant Congress
Sars-cov-2 Antibodies Transitions After Vaccination In Solid Organ Transplant Recipients: Multicenter Study In Japan
K. Unagami¹, M. Yoshikawa², Y. Natori³, K. Omoto¹, H. Ishida¹, H. Date⁴, R. Imamura⁵, T. Ito⁴, K. Miyaji⁶, S. Takahara⁷, K. Yuzawa⁸, O. Satoko⁹, Y. Hirota¹⁰, H. Egawa¹
¹Tokyo Women's Medical University, Tokyo, Japan, ²Kyoto Prefectural University of Medicine, Kyoto, Japan, ³University of Miami, Pinecrest, FL, ⁴Kyoto University, Kyoto, Japan, ⁵Dept. of Urology, Osaka Univ. Graduate School of Medicine, Suita, Japan, ⁶Renal Transplantation, Takatsuki General Hospital, Takatsuki, Japan, ⁷Kansai Medical Hospital, Toyonaka, Japan, ⁸Tranplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan, ⁹Public Health, Osaka City University Graduate School of Medicine and Research Center for Infectious, Osaka City University Graduate School of Medicine, Osaka, Japan, ¹⁰Clinical Epidemiology Research Center, Miyama, Japan
*Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid…
2022 American Transplant Congress
The Use of Donor-Derived Cell-Free DNA in Female and Male Heart Transplant Recipients: A Sex-Specific Analysis of the Surveillance Heartcare Outcomes Registry
E. M. DeFilippis¹, Y. Fu², R. Burke², M. Deng³, M. Kamath⁴, L. Lourenco Jenkins², A. R. Vest⁵
¹Columbia University Irving Medical Center, New York, NY, ²CareDx, Brisbane, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Ronald Reagan UCLA Medical Center, Los Angeles, CA, ⁵Tufts Medical Center, Boston, MA
*Purpose: To investigate sex-specific donor-derived cell-free DNA AlloSure (AS) levels during allograft quiescence and rejection after heart transplantation.*Methods: Sex-stratified data were obtained from the Surveillance…
2022 American Transplant Congress
The Trajectory of Donor-Derived Cell-Free DNA (dd-cfDNA) Complements the Baseline Measurements in Heart Transplant Surveillance for Rejection
P. Shah¹, R. Cheng², H. Eisen³, B. D. Lowes⁴, L. Lourenco Jenkins⁵, Y. Fu⁵, K. Qu⁵, J. Teuteberg⁶, E. DePasquale⁷
¹Inova Heart and Vascular Institute, Falls Church, VA, ²University of Washington Heart Institute, Seattle, WA, ³Pennsylvania State University, Hershey, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵CareDx, Brisbane, CA, ⁶Stanford University, Stanford, CA, ⁷University of Southern California, Los Angeles, CA
*Purpose: Changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the dd-cfDNA…

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