Articles tagged "Multicenter studies"

2022 American Transplant Congress
The Use of Donor-Derived Cell-Free DNA in Female and Male Heart Transplant Recipients: A Sex-Specific Analysis of the Surveillance Heartcare Outcomes Registry
E. M. DeFilippis¹, Y. Fu², R. Burke², M. Deng³, M. Kamath⁴, L. Lourenco Jenkins², A. R. Vest⁵
¹Columbia University Irving Medical Center, New York, NY, ²CareDx, Brisbane, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Ronald Reagan UCLA Medical Center, Los Angeles, CA, ⁵Tufts Medical Center, Boston, MA
*Purpose: To investigate sex-specific donor-derived cell-free DNA AlloSure (AS) levels during allograft quiescence and rejection after heart transplantation.*Methods: Sex-stratified data were obtained from the Surveillance…
2022 American Transplant Congress
The Trajectory of Donor-Derived Cell-Free DNA (dd-cfDNA) Complements the Baseline Measurements in Heart Transplant Surveillance for Rejection
P. Shah¹, R. Cheng², H. Eisen³, B. D. Lowes⁴, L. Lourenco Jenkins⁵, Y. Fu⁵, K. Qu⁵, J. Teuteberg⁶, E. DePasquale⁷
¹Inova Heart and Vascular Institute, Falls Church, VA, ²University of Washington Heart Institute, Seattle, WA, ³Pennsylvania State University, Hershey, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵CareDx, Brisbane, CA, ⁶Stanford University, Stanford, CA, ⁷University of Southern California, Los Angeles, CA
*Purpose: Changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the dd-cfDNA…
2022 American Transplant Congress
Quality of Life of Brazilian Kidney Transplant Patients: A Sub-Project of ADHERE Brazil Multicenter Study
A. R. Almeida¹, F. R. Grincenkov², F. A. Colugnati¹, J. O. Medina³, S. De Geest⁴, H. Sanders-Pinheiro¹, S. ADHERE BRAZIL¹
¹Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Brazil, ²Psychology, Federal University of Juiz de Fora, Juiz de Fora, Brazil, ³Nephrology, Hospital do Rim. Federal University of São Paulo, São Paulo, Brazil, ⁴Department of Public Health, Institute of Nursing Science, Basel, Switzerland
*Purpose: While the quality of life (QoL) is known to improve after kidney transplant (KT), epidemiologic data are limited in Brazil. We aimed to describe…
2022 American Transplant Congress
Prediction Model of Post-Donation Renal Function Using Dynamic Kidney CT Volumetry in Living Donor
S. Lim¹, J. Kwon², Y. Ko¹, H. Kwon¹, J. Jung¹, H. Kwon¹, Y. Kim¹, J. Park², K. Lee², S. Shin¹
¹Asan Medical Center, Seoul, Songpa, Korea, Republic of, ²Samsung Medical Center, Seoul, Gangnam, Korea, Republic of
*Purpose: The risk of renal failure after live kidney donation can be predicted based on various clinical information. We tried introduce a model to predict…
2022 American Transplant Congress
Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance
A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷
¹Centura Health, Denver, CO, ²George Washington University, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵Baylor Scott and White, Austin, TX, ⁶CareDx, Brisbane, CA, ⁷Intermountain Healthcare, Murray, UT
*Purpose: Delta changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the…
2022 American Transplant Congress
Third Dose of SARS-CoV-2 mRNA Vaccines Significantly Increases Delta (B.1.617.2) Variant Anti-Spike Antibody Levels in Kidney Transplant Recipients
A. Al Jurdi¹, R. B. Gassen¹, T. Borges¹, I. T. Lape¹, L. Morena¹, O. Efe¹, Z. Solhjou², R. El Fekih², C. Kotton¹, J. Azzi², L. Riella¹
¹Massachusetts General Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Emerging SARS-CoV-2 variants may be associated with a higher risk of breakthrough infections compared to wild-type (WT) virus in kidney transplant recipients (KTRs). The…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Technology Enabled And Molecular Monitoring Of The Allograft And Transplant Recipient Study
N. Sulejmani¹, D. Axelrod², S. Dholakia¹, S. Shah³
¹CareDx, South San Francisco, CA, ²University of Iowa, Iowa City, IA, ³University of Cincinnati, Cincinnati, OH
*Purpose: With the widespread availability of smart mobile devices, mobile health (mHealth) provides the opportunity to reach wide array of patients. Readmission rates as high…
2022 American Transplant Congress
A Novel Prospective Validation Trial Of Multiple Blood-based RNA Signature Assays Pre And Post Kidney Transplant To Predict Rejection
L. Gallon¹, P. O'Connell², A. Chang³, M. Donovan⁴
¹Northwestern Univ, Chicago, IL, ²Westmead Inst, Sydney, Australia, ³Univ of Chicago, Chicago, IL, ⁴Verici Dx, Franklin, TN
*Purpose: The accuracy and utility of clinically defined and analytically validated predictive biomarkers in kidney transplantation is limited. We leveraged prior feasibility blood-RNA studies to…
2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³UMontreal, Montreal, QC, Canada, ⁴StMH, Toronto, ON, Canada, ⁵Laval U, Quebec, QC, Canada, ⁶UCalgary, Calgary, AB, Canada, ⁷USaskatchewan, Saskatoon, SK, Canada, ⁸HMR, Montreal, QC, Canada, ⁹McGill U, Montreal, QC, Canada, ¹⁰SCH, Edmonton, AB, Canada
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…

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