2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…2019 American Transplant Congress
Peripheral Blood Chemokine Levels in Kidney Allograft Rejection
University Hospitals Leuven, Leuven, Belgium
*Purpose: Cytokines and chemokines play a critical role in acute rejection after kidney transplantation and may be of importance in the quest for better diagnostic…2019 American Transplant Congress
CXCL12-CXCR4-Mediated Chemotaxis is a Potential Mechanism for Monocyte Recruitment in Ischemia-Reperfusion Injury in Orthotopic Liver Transplant Patients
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which lowers allograft survival in orthotopic liver transplant (OLT) patients. Damage-associated molecular patterns, such as high-mobility group box…2019 American Transplant Congress
Immune Cell Types and Host Gene Signatures Associated with Epstein-Barr Virus (EBV) Post-Transplant Lymphoproliferative Disorder (PTLD)
*Purpose: PTLD is a serious post-transplant complication that encompasses a range of abnormal lymphoproliferations, including EBV+ B cell lymphomas. Although many are EBV-driven, a significant…2017 American Transplant Congress
Compartmental Infiltration of Kidney Allograft with Monocyte-Macrophage Subtypes Defines the Type of Rejection.
Purpose: Rejection significantly worsens the graft function and survival. We studied monocyte-macrophage compartmental infiltration of 62 kidney transplant biopsies with diagnosis of: acute antibody mediated…2017 American Transplant Congress
Adoptive Immunotherapy with Liver Allograft-Derived Lymphocytes Compensate for the Susceptibility to Post-Liver Transplant Blood Stream Infection Associated with FCGR3A SNP.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
By studying the single nucleotide polymorphisms (SNPs) of FCGR2A and FCGR3A, genes encoding FcγR, we previously demonstrated the significantly higher incidence of blood stream infections…2017 American Transplant Congress
The Phenotypic and Functional Characteristics of a Novel CD11b+CD11c+F4/80+ Monocytic Myeloid-Derived Suppressor Cell Subset.
Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…2017 American Transplant Congress
Donor-Derived Nonclassical Monocytes Produce MIP-2 to Recruit Recipient Neutrophils and Cause Ischemia Reperfusion Injury After Lung Transplant.
1Northwestern University, Chicago; 2Washington University, St Louis
Purpose: Primary graft dysfunction (PGD), the primary cause of early mortality after lung transplant, is mediated by neutrophils. However, neutrophil depletion may not be clinically…2017 American Transplant Congress
Tacrolimus and Mycophenolic Acid Have a Limited Inhibitory Effect on Monocyte Signaling Pathway Phosphorylation, Function and Differentiation.
Introduction Monocytes and macrophages play key roles in cellular and humoral rejection after solid organ transplantation, but little is known about the effects of the…2017 American Transplant Congress
CD16+ Monocytes and Skewed Macrophage Polarization Towards M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
Purpose: During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is…
American Transplant Congress abstracts