ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Monoclonal antibodies"

  • 2016 American Transplant Congress

    Combined CD122 and Costimulation Blockade Prolongs Allograft Survival by Controlling Expansion and Effector Function of Memory CD8 T Cells.

    D. Mathews,1 Y. Dong,1 L. Higginbotham,1 S. Kim,1 C. Breeden,1 J. Tso,2 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2JN Biosciences, Mountain View, CA.

    CD8 memory T cells rely on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. The addition of anti-CD122 to costimulation blockade prolongs graft…
  • 2015 American Transplant Congress

    Targeting Leukocyte Integrin CD11b/CD18 With a Novel mAb Salvages Renal Function Following an Otherwise Irreversible Ischemic Insult in Cynomolgus Monkeys

    A. Cosimi,1 A. Dehnadi,1 R. Smith,2 D. Ko,1 X. Li,3 M. Arnaout.3

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA; 2Pathology, MGH, Boston, MA; 3Nephrology, MGH, Boston, MA.

    Allograft dysfunction resulting from ischemic reperfusion injury (IRI) leads to increased peri-transplant costs, morbidity, and inferior long-term survival. Leukocyte/endothelial adhesion is an important pathway contributing…
  • 2015 American Transplant Congress

    Eculizumab in the Treatment of Early Severe Acute Antibody Mediated Rejection Following HLA-Compatible Kidney Transplantation-Case Series

    M. Singh,1 N. Macias,2 V. Tatapudi,1 B. Lee.1

    1Transplant Nephrology, UCSF Medical Center, San Francisco, CA; 2Nephrology, Hospital Gregorio Maranon, Madrid, Spain.

    Severe early acute antibody-mediated rejection (AMR) is associated with poor allograft outcomes. Eculizumab is a humanized mouse monoclonal antibody against complement factor C5 that has…
  • 2015 American Transplant Congress

    The Best Regimen With Rituximab for ABO-Incompatible Living Donor Liver Transplantation

    H. Egawa,1 K. Umeshita,2 S. Uemoto.3

    1Surgery, Tokyo Women's Medical University, Tokyo, Japan; 2Osaka University, Suita, Japan; 3Kyoto University, Kyoto, Japan.

    Rituximab made a great progress on outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). Although Japanese multicenter study group published efficacy and safety of…
  • 2015 American Transplant Congress

    Infectious Complications in ABO Incompatible Kidney Transplantation Recipient According to the Rituximab Dose

    J. Lee,1 J. Lee,1 S. Kim,2 M. Ju,1 D. Joo,1 M. Kim,1 S. Kim,1 Y. Kim,1 H. Kim,2 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    BackgroundDesensitization with rituximab and intravenous immunoglobulin improves ABO incompatible (ABOi) kidney transplantation (KT) outcomes. However, infections have been noted in association with rituximab administration. In…
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