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Articles tagged "Monoclonal antibodies"

  • 2020 American Transplant Congress

    Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression

    G. A. Böhmig1, M. Dürr2, B. Jilma3, F. Eskandary1, E. Chong4, S. Schranz3, K. Doberer1, M. Wahrmann1, A. Borski1, H. Regele5, J. Kläger5, R. Reindl-Schwaighofer1, J. Reeve6, K. Budde2, P. F. Halloran6

    1Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2Nephrology Department, Charité Berlin, Berlin, Germany, 3Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, 4Vitaeris Inc., Vancouver, BC, Canada, 5Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, 6Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada

    *Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
  • 2020 American Transplant Congress

    New Strategy to Maximize Nanomedicine Delivery During Ex Vivo Organ Perfusion

    C. Albert1, L. Bracaglia1, A. Koide2, C. M. Edwards3, T. Lysyy3, J. S. Pober4, M. Saltzman1, S. Koide2, G. Tietjen3

    1Biomedical Engineering, Yale University, New Haven, CT, 2Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, 3Surgery, Yale University, New Haven, CT, 4Immunobiology, Yale University, New Haven, CT

    *Purpose: Organ transplant is a highly successful therapy for patients facing end stage organ failure. However, there is a severe lack of transplantable organs which…
  • 2020 American Transplant Congress

    Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection

    K. A. Doberer1, G. A. Boehmig1, M. Streitz2, S. Schlickeiser2, F. Bauernfeind1, A. Spittler3, B. Jilma4, F. Eskandary1, E. Chong5, S. Schranz4, K. Budde6, M. Dürr6

    1Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, 3Center of Translational Research, Medical University of Vienna, Vienna, Austria, 4Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, 5Vitaeris Inc., Vancouver, BC, Canada, 6Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
  • 2020 American Transplant Congress

    CD38 Antibody Daratumumab for the Treatment of Chronic Antibody-Mediated Kidney Allograft Rejection

    K. Doberer1, J. Kläger2, G. A. Gualdoni1, K. Mayer1, F. Eskandary1, H. Agis3, T. Reiter1, R. Reindl-Schwaighofer1, M. Wahrmann1, G. Cohen1, H. Haslacher4, G. Bond1, I. Simonitsch-Klupp5, I. Farkash6, P. Halloran7, G. A. Böhmig1

    1Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, 3Department of Medicine I, Medical University of Vienna, Vienna, Austria, 4Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, 5Department of Pathology, Medical University of Vienna, Vienna, Austria, 6Dept. of Pathology, University of Michigan, Ann Arbor, MI, 7Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada

    *Purpose: Late antibody-mediated rejection (ABMR) is a major cause of transplant failure. Potential therapeutic targets are plasma cells (PC) and natural killer (NK) cells expressing…
  • 2020 American Transplant Congress

    Long Term Outcomes of Kidney Transplantation in Patients with AL-Amyloidosis – The Mayo Clinic Experience

    A. Bentall1, C. Heybali2, J. Wen3, A. Hatem1, C. A. Schinstock1, E. Lorenz1, M. El Ters1, M. Mai4, H. Khamash5, D. Murray6, M. D. Stegall7, F. G. Cosio1, M. P. Alexander6, N. Leung1

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 2School of Medicine, Dokuz Eylul University, Izmir, Turkey, 3National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing, China, 4Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, 5Division of Nephrology and Hypertension, Mayo Clinic, Scottsdale, AZ, 6Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 7Department of Transplant Surgery, Mayo Clinic, Rochester, MN

    *Purpose: New clone-directed therapies and better definition of hematological response criteria allows assessment of post-kidney transplantation outcomes in patients with light-chain (AL) amyloidosis*Methods: Patients with…
  • 2020 American Transplant Congress

    Renal Transplant Induction Therapy Safety Outcomes Comparison

    R. M. Hofmann1, J. Combs2, K. J. Schmidt3, T. Dyckman4

    1Nephrology, Renal Associates of West Michigan, Grand Rapids, MI, 2Pharmacy/Transplant, Mercy Health St. Mary's, Grand Rapids, MI, 3Pharmacy, Ferris State University College of Pharmacy, Big Rapids, MI, 4Pharmacy, Mercy Health St. Mary's, Grand Rapids, MI

    *Purpose: Induction immunosuppression with alemtuzumab and rabbit anti-thymocyte globulin (r-ATG) reduces acute rejection following kidney transplantation. Efficacy is thought to be similar between the agents…
  • 2020 American Transplant Congress

    Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation

    A. Bentall1, C. Heybeli2, F. G. Cosio1, M. El Ters1, N. Leung1, M. P. Alexander3

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
  • 2020 American Transplant Congress

    Pneumocystis Pneumonia Occurrence and Prophylaxis Duration in Kidney Transplant Recipients According to Perioperative Treatment with Rituximab

    Y. Ko, Y. Kim, D. Han, H. Kwon

    Department of Surgery, Division of Kidney and Pancreas Transplant, AMC, Seoul, Korea, Republic of

    *Purpose: Pneumocystis pneumonia (PCP) is a life-threatening fungal infection that can occur in kidney transplantation (KT) recipients. A growing number of KT recipients are receiving…
  • 2019 American Transplant Congress

    The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model

    J. Min1, H. Lee2, B. Kim3, K. Park4, K. Doh3, T. Kim5, H. Yoon6, C. Yang7, E. Oh2, B. Chung7

    1Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-si, Korea, Republic of, 2Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 3Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 4Department of Molecular & Cell Biology, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 5Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 6Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea, Republic of, 7Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of

    *Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…
  • 2019 American Transplant Congress

    Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center

    J. S. Kerr, N. Law, S. Aslam

    Center for Transplantation, University of California, San Diego Health System, La Jolla, CA

    *Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…
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