Articles tagged "Monitoring"

2020 American Transplant Congress
Evaluation of the Economic Impact of a New IVD Immunoassay (Immunobiogram) for Immunosuppressive Treatment Adjustment in Kidney Transplant Recipients in Spain
C. Rubio¹, C. Jiménez², M. Crespo³, J. Portolés⁴, D. Rubio¹, T. Diez⁵, I. Portero⁵
¹Health Value, Madrid, Spain, ²La Paz Hospital, Madrid, Spain, ³Consorci Mar Parc de Salut, Barcelona, Spain, ⁴Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ⁵Biohope Scientific Solutions for Human Health SL, Madrid, Spain
*Purpose: Immunobiogram (IMBG) is a new IVD bioassay developed by Biohope SL with the aim to support clinicians in the personalized adjustment of immunosuppressive therapy…
2020 American Transplant Congress
Optimal Transition for Transplant Recipients: A Model of Care in an Integrated Health Care System
S. Zheng¹, L. Pravoverov¹, A. Nazarova¹, D. Adey², N. B. Goes¹
¹The Permanente Medical Group, San Francisco, CA, ²Kidney and Transplantation Program, University of California San Francisco, San Francisco, CA
*Purpose: Transplantation is the treatment of choice for ESRD. While short-term outcomes have improved, long-term outcomes lag. Many factors may explain the long-term lag including…
2020 American Transplant Congress
An Early Look at the National Liver Review Board
S. Noreen¹, R. Hirose², J. Trotter³, J. Heimbach⁴
¹United Network for Organ Sharing, Richmond, VA, ²University of California - San Francisco, San Francisco, CA, ³Texas Digestive Disease Consultants, Dallas, TX, ⁴Mayo Clinic, Rochester, MN
*Purpose: On May 14, 2019, the National Liver Review Board (NLRB) was implemented, establishing a national structure for liver exceptions comprised of three specialty review…
2020 American Transplant Congress
Monitoring Recipients of Public Health Service (PHS) Increased Risk Donors Using an Electronic Medical Record-Based System
M. Malinis¹, B. Nuesse², S. Carter², S. Emre¹, R. Formica¹, S. Kulkarni¹, D. Mulligan¹, M. Schilsky¹, M. M. Azar¹
¹Yale School of Medicine, New Haven, CT, ²Yale New Haven Health, New Haven, CT
*Purpose: In 2014, the Organ Procurement and Transplantation Network (OPTN) policy was updated, mandating transplant centers to implement a post-transplant screening protocol for transmissible diseases.…
2020 American Transplant Congress
Non-Invasive Near Infrared Fluorescence Based Monitoring of Macrophage Mediated Inflammation
H. Karagoz¹, N. Vettikattu¹, F. Selek¹, H. Kapucu¹, E. Goktas¹, L. Liu², Y. Kulahci¹, F. Zor¹, J. M. Janjic², V. S. Gorantla¹
¹Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, ²Department of Pharmaceuticals, Duquesne University, Pittsburgh, PA
*Purpose: Clinical assessments for inflammation and acute rejection (AR) require regular, invasive biopsies followed by staining protocols that provide static images of tissue. Despite such…
2020 American Transplant Congress
Validity and Utility of Urinary CXCL10/Cr Monitoring in Pediatric Kidney Transplant Recipients
T. Blydt-Hansen¹, A. Sharma², I. Gibson², C. Weibe², A. Sharma³, V. Langlois⁴, C. Teoh⁴, D. Rush², P. Nickerson², D. Wishart⁵, J. Ho²
¹University of British Columbia, Vancouver, BC, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Western Ontaria, London, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Alberta, Edmonton, AB, Canada
*Purpose: Effective post-transplant monitoring is hampered by a lack of effective biomarkers. We sought to validate the utility of urinary CXCL10/Cr monitoring of rejection in…
2020 American Transplant Congress
Membrane Expression of CD163 and CD206 by Blood Monocytes is Upregulated in Kidney Allograft Recipients
I. Striz, L. Curnova, V. Svachova, M. Fialova, M. Novotny, O. Viklicky
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Blood monocytes differentiating into tissue macrophages or dendritic cells are involved in multiple immune responses including reactions to the transplanted allograft. Peripheral monocytes can…
2020 American Transplant Congress
Torque Teno Virus Level for Risk Stratification of Subclinical Graft Rejection at 12 Months after Kidney Transplantation – An Prospective Observational Cohort Study
K. Doberer, E. Puchhammer, G. Böhmig, G. Bond
Medical University Vienna, Vienna, Austria
*Purpose: Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno…
2020 American Transplant Congress
A Novel Immunoresponse Monitoring System to Predict Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, D. Iwami¹, Y. Takada¹, H. Higuchi², H. Sasaki², T. Tanabe², N. Shinohara¹
¹Hokkaido University, Sapporo, Japan, ²Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody mediated rejection (CAAMR) induced by de novo donor specific antibodies (DSA) is the main cause of graft loss in the long-term.…
2020 American Transplant Congress
T-cell Receptor Deep Sequencing to Distinguish Autoimmune Recurrence from Allograft Rejection in Liver Transplant Patients with Autoimmune Liver Disease
K. J. Yang¹, M. Martinez², B. Shonts¹, C. A. Parks¹, A. Z. Obradovic¹, T. M. Savage¹, E. Spyrou¹, S. Lau¹, M. I. Colquhoun¹, K. Rodgers¹, E. Verna³, S. M. Coley⁴, S. Yang¹, Y. Shen⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Department of Medicine, Columbia University, New York, NY, ⁴Department of Pathology, Columbia University, New York, NY, ⁵Center for Computational Biology & Bioinformatics, Department of Systems Biology, Columbia University, New York, NY
*Purpose: Patients who undergo liver transplantation for autoimmune liver disease (ALD) experience high rates of graft failure. The relative roles of recurrent ALD and rejection…

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