2021 American Transplant Congress
A Kidney Waitlist Outcomes Timeline to Visualize Candidate Offers and Outcomes
*Purpose: While transplant centers closely monitor posttransplant outcomes for each transplant recipient, centers currently lack data to monitor waitlist outcomes of individual candidates. Candidates who…2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…2021 American Transplant Congress
Role of Serial Donor Derived Cell-Free DNA Monitoring in Kidney Transplant Recipients
Nephrology, Stanford University School of Medicine, Palo Alto, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA; Allosure, CareDx) is increasingly employed for non-invasive kidney transplant monitoring. The goal of this study was 1) to…2021 American Transplant Congress
The Clinical Validation of a Dried Blood Spot Method for Simultaneous Tacrolimus and Creatinine Measurement
*Purpose: Monitoring tacrolimus concentrations and kidney function after transplantation is important to avoid tacrolimus under- and overexposure and its clinical consequences, including acute nephrotoxicity. Using…2021 American Transplant Congress
Donor Derived Cell-free DNA Kinetics Early After Kidney Transplant in Patients with Delayed Graft Function Who Received Kidneys from Donation After Cardiac Death Donors
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) may reduce long-term kidney allograft survival due to ischemia-reperfusion injury and rejection. Donor Derived Cell-Free DNA (dd-cfDNA) is proposed to…2021 American Transplant Congress
Immunologic Endotypes of Ischemia-reperfusion Injury in Human Liver Transplantation
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft rejection in orthotopic liver transplantation (OLT), involving complex interactions between innate and adaptive immune…2021 American Transplant Congress
Donor-Derived Cell-Free DNA as a Surrogate Marker for “Allograft Quiescence” After Kidney Transplantation
*Purpose: Donor-derived cell-free DNA (dd-cfDNA; AlloSure®) and the association with active rejection (AR) was described by Bloom et al, however subsequent insights have suggested this…2021 American Transplant Congress
High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…2021 American Transplant Congress
Solid Organ Transplant Telehealth Utilization Significantly Increased During the Covid-19 Pandemic: Experience at a Single, Large Volume Center
Vanderbilt University Medical Center, Nashville, TN
*Purpose: During the COVID-19 pandemic, telehealth utilization has allowed for the delivery of healthcare while protecting patients, caregivers, healthcare workers, and the community from exposure.…2020 American Transplant Congress
Renal Allograft Surveillance with Allospecific T-cytotoxic Memory Cells Which Express CD154
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Allo-antigen-specific T-cytotoxic memory cells (TcM) which express CD40 ligand (CD154) in overnight lymphocyte co-culture are strongly associated with acute cellular rejection (ACR) seen in…
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