Articles tagged "Monitoring"

2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2016 American Transplant Congress
Circulating miR-215, miR-let-7c miR-154, miR-193a, NR_036506.1 and NR_027669.1 as Biomarkers Predict Fungal Infection in Post-Transplanted Recipients.
A. Yang, Z. Guo, W. Ju, C. Zhang, Z. Li, X. Yuan, Q. Zhao, H. Ye, Y. Liao, X. Zhu, X. He.
Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims: The incidence of fungal infection in post-transplanted patients is 13%-17%, which seriously effecting perioperative survival and increasing their economic burden. We wanted to find…
2016 American Transplant Congress
Circulating Angiotensin II Receptor: Possible Marker for Antibody Mediated Tissue Injury?
P. Kimball, F. McDougan, G. Gupta.
Transplant Surgery, VCU Health, Richmond, VA.
Background. Antibody mediated rejection is the leading cause of renal allograft failure. Membrane-bound angiotensin II receptor(AngII) in the renal allograft can be a target of…
2016 American Transplant Congress
A Model to Explore the Potential Budget Impact of a Novel Screening Tool for the Detection of Subclinical Rejection Among Kidney Transplant Patients.
K. Jaglinski,¹ H. Uchida,¹ T. Inocencio,² K. Hughes.²
¹Immucor, Inc, Waukesha, WI; ²Avalare Health, LLC, Washington, DC.
Background: Acute rejection among kidney transplant patients is common, with ~10% of individuals experiencing acute rejection within the first year and rising to 16-17% at…
2016 American Transplant Congress
Predictors of eGFR Slope at One Year in Kidney Transplants – A Big Data Approach.
J. Zhang, Z. Su, D. Taber, J. Marsden, W. Moran, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Estimated glomerular filtration rate (eGFR), a predictor of graft loss (GL) in kidney transplantation could inform intervention. National data yield eGFRs at fixed time…
2016 American Transplant Congress
Clinical Significance of Mycophenolic Acid Therapeutic Drug Monitoring in Kidney Transplant Recipients.
C.-D. Kim, J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim.
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Background: Mycophenolic acid (MPA) is a widely used immunosuppressant to prevent acute rejection in kidney transplant recipients (KTRs). However, clinical significance of MPA therapeutic drug…
2016 American Transplant Congress
Relationship Between Mean Fluorescence Intensity and C1q/C3d-Fixing Capacities of Anti-HLA Antibodies.
G. Claisse,¹ L. Absi,² E. Alamartine,¹ N. Maillard,¹ C. Mariat.¹
¹Centre Hospitalier Universitaire - Hôpital Nord, Saint-Etienne, France; ²Laboratoire EFS Loire-Auvergne, Saint-Etienne, France.
The capacity of anti-HLA antibodies (Abs) to activate complement is thought to be an informative property susceptible to facilitate outcome prediction. Two different tests, C1q-…
2016 American Transplant Congress
Evaluation of Patient-Reported Nonadherence with Tacrolimus Level Variability in Renal Transplant Recipients.
N. Parrish,¹ T. Kaiser,² A. McCann,¹ J. Aladimi,² J. Harris,³ A. Govil,² B. Abu Jawdeh,² G. Mogilishetty,² R. Alloway,² E. Woodle.²
¹Pharmacy Services, University of Cincinnati Medical Center, Cincinnati, OH; ²Medicine, University of Cincinnati, Cincinnati, OH; ³Transplant, University of Cincinnati Medical Center, Cincinnati, OH.
Medication nonadherence (NA) continues to be a major cause of graft loss post-transplant. Several methods for prospective adherence monitoring have been described including patient interview…
2016 American Transplant Congress
Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.
J. Ho,¹ A. Sharma,² R. Mandal,³ D. Wishart,³ C. Wiebe,¹ L. Storsley,¹ M. Karpinski,¹ I. Gibson,⁴ P. Nickerson,¹ D. Rush.¹
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, Canada; ³Biological Sciences, University of Alberta, Edmonton, AB, Canada; ⁴Pathology, University of Manitoba, Winnipeg, MB, Canada.
Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…
2016 American Transplant Congress
Continuous Glucose Monitoring in the First 6 Weeks After Transplantation in Pancreas Transplant Recipients.
K. Bonner,¹ V. Dadlani,² P. Thapa,² M. Stegall,¹ Y. Kudva.²
¹Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester; ²Department of Medicine, Division of Endocrinology, Mayo Clinic, Rochester.
Introduction The maturation of Continuous glucose monitoring (CGM) technology enables accurate characterization of daily glucose control. We investigated glucose control using CGM in the first…