Articles tagged "Monitoring"

2018 American Transplant Congress
Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)
L. Zhao,¹ B. Armstrong,² J. Friedewald,¹ T. Whisenant,³ S. Kurian,³ R. Heilman,⁴ E. Poggio,⁵ C. Marsh,³ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ D. Ikle,² J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ M. Kandpal,¹ D. Salomon,³ M. Abecassis.¹
¹Northwestern, Chicago; ²Rho, Chapel Hill; ³Scripps, La Jolla; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
BACKGROUNDSubAR can currently only be detected using surveillance biopsies (SBx) and is associated with poor long-term graft outcomes. Response to treatment is difficult to assess.…
2018 American Transplant Congress
The Efficacy of Laser Speckle Flowgraphy Device for Intraoperative Evaluation of Renal Blood Flow after Reperfusion
M. Muramatsu,¹ Y. Itabashi,¹ Y. Takahashi,² K. Sakurabayashi,¹ T. Mizutani,¹ Y. Hyodo,¹ Y. Hamasaki,² T. Kawamura,¹ K. Sakai,¹ S. Shishido.^1,2
¹Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
Purpose:Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. However, there is no report that the device was used…
2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott & White Research Institute, Dallas; ²Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…
2018 American Transplant Congress
Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients
J. Bruminhent,¹ S. Srisala,² C. Klinmalai,³ S. Pinsai,¹ S. Watcharananan,¹ S. Kantachuvessiri,⁵ S. Hongeng,⁴ N. Apiwattanakul.³
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ²Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ³Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁴Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…
2018 American Transplant Congress
What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls
M. Sosniuk,¹ A. Halpin,^1,2,5,6,7 J. Wizniak,⁷ A. Szkotak,^6,7 S. Urschel,^1,2,5 L. Ionescu,^1,2,5 L. West.^1,2,3,4,5,6
¹Dept of Pediatrics, U of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Dept of MMI, U of Alberta, Edmonton, Canada; ⁴Dept of Surgery, U of Alberta, Edmonton, Canada; ⁵Canadian National Transplant Research Program, National, Canada; ⁶Dept of Laboratory Medicine, U of Alberta, Edmonton, Canada; ⁷Laboratory Medicine and Pathology, Alberta Health Services, Edmonton, Canada.
INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…
2018 American Transplant Congress
Monitoring of Small Bowel Allografts with Kynurenine Serum Levels
M. Stangl,¹ D. Koliogiannis,¹ J. Bucher,¹ M. Guba,¹ D. Abendroth.²
¹Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; ²Department of Surgery, University of Ulm, Ulm, Germany.
Long-term success in intestinal transplantation could be significantly improved by the development of a reliable noninvasive marker of rejection, allowing early diagnosis and treatment without…
2018 American Transplant Congress
Polyclonal Cellular Immune Function is Dose-Dependently Inhibited by Immunosuppressive Drugs but Has Limited Value in Predicting Infection or Rejection Episodes
S. Marx,¹ C. Adam,² S. Leyking,² U. Sester,² M. Sester.
¹Saarland University, Homburg/Saar, Germany; ²Saarland University, Homburg/Saar, Germany.
Background: Dosage of immunosuppressive drugs in transplant patients must be balanced to prevent graft rejection and infectious complications. Knowledge on general immune function may therefore…
2018 American Transplant Congress
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients
J. Bank,¹ R. Ruhaak,² D. Soonawala,¹ F. Romijn,² C. van Kooten,¹ C. Cobbaert,² H. de Fijter.¹
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…
2018 American Transplant Congress
Klotho, HMGB-1 and Kynurenine as Marker for Injury and Function in Renal Transplantation
M. Stangl,¹ D. Abendroth.²
¹Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; ²Surgery, University of Ulm, Ulm, Germany.
Brain death is associated with immune activation and tissue injuries, counter regulated by activation of the tryptophan pathway producing kynurenine (Kyn). High mobility group box…
2018 American Transplant Congress
Clinical Validation of a Novel ELISpot-Based In Vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in Kidney Transplant Recipients
B. Banas,¹ D. Steubl,² L. Renders,² D. Chittka,¹ M. Banas,¹ T. Wekerle,³ M. Koch,⁴ O. Witzke,⁵ A. Muehlfeld,⁶ C. Sommerer,⁷ A. Habicht,⁸ C. Hugo,⁹ T. Huenig,¹⁰ M. Lindemann,⁵ T. Schmidt,¹¹ A. Rascle,¹¹ S. Barabas,¹¹ L. Deml,¹¹ R. Wagner,^1,11 B. Kraemer,¹² B. Krueger.¹²
¹University Clinic, Regensburg, Germany; ²Clinic rechts der Isar TUM, Munich, Germany; ³Medical University, Vienna, Austria; ⁴University Clinic, Hamburg-Eppendorf, Germany; ⁵University Hospital, Essen, Germany; ⁶Uniklinik RWTH, Aachen, Germany; ⁷University Hospital, Heidelberg, Germany; ⁸LMU Medical Center, Munich, Germany; ⁹University Hospital, Dresden, Germany; ¹⁰University Hospital, Wuerzburg, Germany; ¹¹Lophius Biosciences, Regensburg, Germany; ¹²UMM Uni. Heidelberg, Mannheim, Germany.
Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause ofCMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually…