Articles tagged "Monitoring"

2018 American Transplant Congress
Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy
M. Banas,¹ S. Neumann,² P. Pagel,² D. Chittka,¹ V. Pfahlert,² B. Banas.¹
¹Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; ²numares HEALTH, Regensburg, Germany.
Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…
2018 American Transplant Congress
High Grade Cytomegalovirus Viremia Events in Solid Organ Transplant Recipients: Description and Quality Improvement
M. Spinner,¹ V. Athans,¹ C. Koval.²
¹Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; ²Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.
Background: High grade cytomegalovirus viremia (HGCMVV) often results in symptomatic disease requiring IV antiviral therapy and is associated with CMV recurrence and resistance. We postulated…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
2018 American Transplant Congress
Evaluation and Cost Burden of Inappropriately Drawn Immunosuppression Trough Levels in the Acute Care Setting at an Academic Medical Center
A. Brown, J. Geyston, A. Agarwal, B. Jones, W. Ally.
University of Virginia Health System, Charlottesville, VA.
Trough drug levels in narrow therapeutic index medications, such as CNI and mTOR inhibitors are used to estimate total drug exposure. Inappropriately measured trough levels…
2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ L. Clementoni,¹ P. Messa,³ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; ³Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
2018 American Transplant Congress
The Effect of Tacrolimus Trough Level and Intrapatient Variability on the Transplant Outcomes in Kidney Transplantation
J. Lee,¹ J. Lee,¹ Y. Jung,¹ D. Kim,¹ S. Song,² J. Lee,³ J. Lee,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ B. Kim,⁴ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ³Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁴Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Tacrolimus (TAC) is the mainstay of immunosuppression for kidney transplantation (KT). Although TAC has a narrow therapeutic index, appropriate trough concentrations of TAC have…
2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
D. Dadhania,¹ P. Burnham,² J. Lee,¹ C. Snopkowski,¹ C. Li,¹ S. Albakry,¹ H. Yang,¹ T. Muthukumar,¹ I. De Vlaminck,² M. Suthanthiran.¹
¹Transplantation Medicine-Nephrology, Weill Cornell Medicine, NY, NY; ²Biomedical Engineering, Cornell University, Ithaca, NY.
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
2018 American Transplant Congress
A Novel Combined Formula to Direct Optimal Immunosuppressive Drug Exposure in Renal Transplant Recipients
O. Pankewycz,¹ E. Onan,² M. Laftavi,¹ R. Gruessner,³ H. Smileuski,¹ E. Alissandrello,¹ A. Gruessner.³
¹Upstate Medical University, Syracuse, NY; ²Cukurova University, Adana, Turkey; ³Downstate Medical University, New York, NY.
Purpose: The most widely used maintenance immunosuppressive combination after kidney transplantation is tacrolimus (TAC) and mycophenolic acid (MPA). The utility of therapeutic drug monitoring for…
2018 American Transplant Congress
The Results of the PRISM (Prediction of Rejection In Sensitized Patient Blood SaMples) Trial with a Novel Bioassay
F. Vincenti, A. Schroeder, S.-C. Hseish, J. Liberto, P. Towfighi, C. Koh, T. Sigdel, M. Sarwal.
Surgery and Medicine, University of California San Francisco, San Francisco.
Background. kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of BPAR and immune quiescence in kidney tx. This is the first…
2018 American Transplant Congress
Urinary CXCL9 Monitoring to Accompany a Safe CNI-to-Belatacept Conversion in Kidney Transplant Patients
P. Malvezzi,¹ C. Fischman,² T. Jouve,¹ B. Janbon,¹ P. Heeger,² L. Rostaing,¹ P. Cravedi.²
¹Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France; ²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Converting renal transplant recipients from CNI to belatacept immunosuppression has been proposed as a strategy to limit nephrotoxicity, but it is associated with an…