ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Monitoring"

  • 2018 American Transplant Congress

    What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls

    M. Sosniuk,1 A. Halpin,1,2,5,6,7 J. Wizniak,7 A. Szkotak,6,7 S. Urschel,1,2,5 L. Ionescu,1,2,5 L. West.1,2,3,4,5,6

    1Dept of Pediatrics, U of Alberta, Edmonton, Canada; 2Alberta Transplant Institute, Edmonton, Canada; 3Dept of MMI, U of Alberta, Edmonton, Canada; 4Dept of Surgery, U of Alberta, Edmonton, Canada; 5Canadian National Transplant Research Program, National, Canada; 6Dept of Laboratory Medicine, U of Alberta, Edmonton, Canada; 7Laboratory Medicine and Pathology, Alberta Health Services, Edmonton, Canada.

    INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…
  • 2018 American Transplant Congress

    Monitoring of Small Bowel Allografts with Kynurenine Serum Levels

    M. Stangl,1 D. Koliogiannis,1 J. Bucher,1 M. Guba,1 D. Abendroth.2

    1Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; 2Department of Surgery, University of Ulm, Ulm, Germany.

    Long-term success in intestinal transplantation could be significantly improved by the development of a reliable noninvasive marker of rejection, allowing early diagnosis and treatment without…
  • 2018 American Transplant Congress

    Polyclonal Cellular Immune Function is Dose-Dependently Inhibited by Immunosuppressive Drugs but Has Limited Value in Predicting Infection or Rejection Episodes

    S. Marx,1 C. Adam,2 S. Leyking,2 U. Sester,2 M. Sester.

    1Saarland University, Homburg/Saar, Germany; 2Saarland University, Homburg/Saar, Germany.

    Background: Dosage of immunosuppressive drugs in transplant patients must be balanced to prevent graft rejection and infectious complications. Knowledge on general immune function may therefore…
  • 2018 American Transplant Congress

    Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients

    J. Bank,1 R. Ruhaak,2 D. Soonawala,1 F. Romijn,2 C. van Kooten,1 C. Cobbaert,2 H. de Fijter.1

    1Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.

    Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…
  • 2018 American Transplant Congress

    Klotho, HMGB-1 and Kynurenine as Marker for Injury and Function in Renal Transplantation

    M. Stangl,1 D. Abendroth.2

    1Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; 2Surgery, University of Ulm, Ulm, Germany.

    Brain death is associated with immune activation and tissue injuries, counter regulated by activation of the tryptophan pathway producing kynurenine (Kyn). High mobility group box…
  • 2018 American Transplant Congress

    Clinical Validation of a Novel ELISpot-Based In Vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in Kidney Transplant Recipients

    B. Banas,1 D. Steubl,2 L. Renders,2 D. Chittka,1 M. Banas,1 T. Wekerle,3 M. Koch,4 O. Witzke,5 A. Muehlfeld,6 C. Sommerer,7 A. Habicht,8 C. Hugo,9 T. Huenig,10 M. Lindemann,5 T. Schmidt,11 A. Rascle,11 S. Barabas,11 L. Deml,11 R. Wagner,1,11 B. Kraemer,12 B. Krueger.12

    1University Clinic, Regensburg, Germany; 2Clinic rechts der Isar TUM, Munich, Germany; 3Medical University, Vienna, Austria; 4University Clinic, Hamburg-Eppendorf, Germany; 5University Hospital, Essen, Germany; 6Uniklinik RWTH, Aachen, Germany; 7University Hospital, Heidelberg, Germany; 8LMU Medical Center, Munich, Germany; 9University Hospital, Dresden, Germany; 10University Hospital, Wuerzburg, Germany; 11Lophius Biosciences, Regensburg, Germany; 12UMM Uni. Heidelberg, Mannheim, Germany.

    Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause ofCMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually…
  • 2018 American Transplant Congress

    Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts

    M. Narayanan,1 T. Alhamad,2 D. Hiller,3 J. Yee,3 R. Woodward,3 J. Bromberg.4

    1Texas A&M Health Science Center, Temple, TX; 2Washington University School of Medicine, St. Louis, MO; 3CareDx, Brisbane, CA; 4University of Maryland School of Medicine, Baltimore, MD.

    Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…
  • 2018 American Transplant Congress

    Estimation of Beta Cell Function after Total Pancreatectomy with Islet Autotransplantation Using Single Fasting Blood Sample Based Indices and Modified Igls Score.

    J. Gołębiewska,1 P. Bachul,2 L. Basto,2 M. Kijek,2 N. Fillman,2 K. Cieply,2 K. Golab,2 L. Wang,2 M. Tibudan,2 C. Thomas,3 A. Dębska-Ślizień,1 J. Fung,2 P. Witkowski.2

    1Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; 2Surgery, University of Chicago, Chicago; 3Medicine, University of Chicago, Chicago.

    Background: For precise yet logistically feasible evaluation of beta-cell function after total pancreatectomy with islet autotransplantation (TPIAT), we investigated the utility of indices using only…
  • 2018 American Transplant Congress

    Four Eyes Are Better Than Two: Improving Laboratory Report Quality Control

    S. Dionne,2 K. Klama,2 H. Rashid,2 A. Niedzinski.2

    1Quality Assurance, LABS, Inc., Centennial, CO; 2Infectious Disease, LABS, Inc., Philadelphia, PA.

    Background: Our STAT donor-screening lab implemented a new LIMS that is used to manage patient orders, testing and reporting. We intentionally customized the LIMS to…
  • 2018 American Transplant Congress

    T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism

    K. Hotta, T. Oura, A. Dehnadi, K. Huh, M. Matsunami, H. Sasaki, G. Benichou, J. Madsen, A. Cosimi, T. Kawai.

    Center for Transplant Science, Massachusetts General Hospital, Boston, MA.

    Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…
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