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American Transplant Congress abstracts

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Articles tagged "Miniature pigs"

  • 2019 American Transplant Congress

    Patterns of Rejection in Murine, Porcine, and Human Vascularized Composite Allografts Based on Clinical, Histologic, and Immunohistochemical Analysis

    M. J. Grzelak, J. W. Etra, F. A. Chang, G. J. Furtmüller, A. R. Ahmadi, F. Nägele, Y. Guo, K. Kambarashvili, A. Jain, S. A. Beck, C. F. Brayton, I. B. Sander, W. A. Lee, G. Brandacher

    Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: The side effects of chronic immunossupression limit the more extensive use of Vascularized Composite Allotransplantation (VCA), and because reliable pre-clinical animal models will be…
  • 2019 American Transplant Congress

    A Novel Multi-Thermic, Antiseptic, and Anthropomorphic System for Ex-Vivo Face Perfusion

    J. W. Etra1, J. Brassil2, F. A. Chang1, S. A. Fidder1, D. S. Cooney1, G. Brandacher1

    1Johns Hopkins University School of Medicine, Baltimore, MD, 2Functional Circulation LLC, Northbrook, IL

    *Purpose: Facial disfigurement is profoundly disabling, and great relief follows resolution by facial transplantation, now a technical reality at multiple centers worldwide. However, distance between…
  • 2019 American Transplant Congress

    Ex-vivo Xenoperfusion Of Wild Type And Galtko.hcd55 Pig Livers With Human Whole Blood

    D. Detelich, C. Rickert, C. Eymard, C. Carroll, S. Kimura, H. Yeh, J. Markmann

    Massachusetts General Hospital, Boston, MA

    *Purpose: Pig-to-human liver xenotransplantation is not currently feasible due to rapid and profound thrombocytopenia, coagulopathy and hyperacute rejection. Successful development of genetically modified swine to…
  • 2018 American Transplant Congress

    Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model

    J. Etra,1 K. Cilwa,2 G. Furtmueller,1 A. Leto Barone,1 K. Kolegraff,1 E. Elster,1 W. Lee,1 G. Brandacher.1

    1Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 2Naval Medical Research Center, Silver Springs, MD; 3Department of Surgery, Uniformed Services, University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.

    PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…
  • 2018 American Transplant Congress

    Comparative Analysis of Bone Marrow versus Blood Monocyte-Derived Regulatory Dendritic Cells for Evaluation in a Miniature Swine Vascular Composite Allotransplantation Model

    T. Elgendy,1 D. Kim,2 A. Zahorchak,1 M. Ezzelarab,1 M. Solari,2 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background: Dendritic cell therapy is a promising approach to reduced dependence on immunosuppressive drugs and for the promotion of tolerance in transplant recipients. Our aim…
  • 2017 American Transplant Congress

    Successful Induction of Tolerance of Fully Allogeneic Lung Graft with Adenosine A2A Receptor (A2AR) Agonist in MHC-Defined CLAWN Miniature Swine.

    H. Sahara, M. Sekijima, T. Murokawa, Y. Ariyoshi, T. Iwanaga, Y. Ichinari, A. Shimizu, K. Yamada.

    Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    Introduction: A2AR agonist is known to potently attenuate lung ischemia-reperfusion injury. However, the long-term effects of A2AR agonist on lung allograft survival remain unclear especially…
  • 2017 American Transplant Congress

    CTLA4-Ig, Vascularized Bone Marrow and Donor Bone Marrow Cells Successfully Negate the Development of Acute Skin Rejection of Vascularized Composite Allografts in MHC Class I Mismatched Recipients.

    I. Schol, Z. Ng, A. Lellouch, A.-R. Gama, J. Kurtz, C. Cetrulo.

    Massachusetts General Hospital, Boston

    PURPOSE: Previously we have shown that MHC class I-mismatched recipient miniature swine (n=3) experienced rejection (from POD42 onwards) of the epidermal component of fasciocutaneous vascularized…
  • 2017 American Transplant Congress

    Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.

    Y. Ariyoshi, M. Sekijima, H. Sahara, T. Murokawa, A. Shimizu, K. Yamada.

    Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…
  • 2016 American Transplant Congress

    Vascularized Composite Allograft Tolerance with Transient High-Dose Tacrolimus Across a Full MHC Mismatch in a Large Animal Model.

    H. Wang, E. Swanson, H.-T. Cheng, J. Walch, J. Alonso-Esclante, K. Kolegraff, J. Lopez, G. Furtmuller, B. Oh, A. Quan, J. Budihardjo, S. AlFadil, S. Mulla, P. Akre, J. Sacks, S. Bonawitz, G. Raimondi, J. Shores, D. Cooney, W. Lee, G. Brandacher.

    Department of Plastic Surgery, Johns Hopkins University, Baltimore, MD.

    PURPOSE: Vascularized composite allografts (VCA) can enhance the quality of life of patients with severe facial or extremity injuries, and the induction of tolerance would…
  • 2015 American Transplant Congress

    Chimeric Thymus Versus Antigen Presenting Thymus for the Induction of Tolerance: Donor DCs in Vascularized Thymus Grafts Play an Essential Role in the Induction of Tolerance

    K. Yamada, M. Sekijima, A. Kawai, T. Tanabe, M. Tasaki, V. Villani, I. Hanekamp, A. Shimizu, D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

    We have demonstrated that thymus plays an important role in transplantation tolerance in MHC inbred large animals. We have established a technique of isolated vascularized…
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