2017 American Transplant Congress
HLA-C Mismatching and Humoral Alloimmune Responses in Pediatric Kidney Recipients with Subclinical Vascular Injury.
University of Alabama at Birmingham, Birmingham, AL
Background: Antibodies to mismatched donor HLA antigens (DSA) have been associated with poor long-term outcomes in adult kidney recipients. We recently demonstrated a high prevalence…2016 American Transplant Congress
Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…2016 American Transplant Congress
Plasma Endothelial Microvesicle Counts Indicate Allograft Rejection Following Kidney Transplantation.
Background: The release of surface-derived microvesicles (MV) is a common phenomenon of cellular activation and occurs specifically as a consequence of terminal complement complex assembly…2015 American Transplant Congress
Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection
Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…2015 American Transplant Congress
High-Resolution Perfusion Mapping to Detect Heart Transplant Rejection Using Contrast Enhance Ultrasound
Background: One of the key unmet needs in heart transplantation is an effective and accurate, non-invasive tool to diagnose acute and chronic heart transplant rejection.…2015 American Transplant Congress
Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years
BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…2015 American Transplant Congress
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome
1Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; 2Lab de HLA, InCor, S Paulo, SP, Brazil.
Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…2015 American Transplant Congress
The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection
BackgroundThere have been marked advances of immunosuppression. However, management of late onset antibody-mediated rejection (AMR) after 6 months is still challenging. Despite important diagnostic and…
American Transplant Congress abstracts