ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Microcirculation"

  • 2022 American Transplant Congress

    Maturation and Evaluation of 3D Printed Bionic Pancreas with a Dedicated Bioreactor

    A. Berman1, M. Klak2, T. Dobrzanski3, T. Bryniarski3, M. Kolodziejska3, G. Tymicki3, M. Wszola3

    1Polbionica Ltd., Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: The technology of 3D printing of bionic organs gives an opportunity to solve the problems of classical transplantology, such as the shortage of organs,…
  • 2020 American Transplant Congress

    Comparison of Intraoperative Cortical Renal Blood Flow after Reperfusion Using Laser Speckle Flowgraphy Device between Adult and Pediatric Kidney Transplants

    M. Muramatsu, K. Sakurabayashi, Y. Itabashi, Y. Takahashi, T. Mizutani, K. Nishikawa, T. Yonekura, H. Oguchi, K. Shinoda, Y. Hamasaki, T. Kawamura, K. Sakai, S. Shishido

    Nephrology, Toho University Faculty of Medicine, Tokyo, Japan

    *Purpose: Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. The aim of this study reveals that the differences…
  • 2017 American Transplant Congress

    HLA-C Mismatching and Humoral Alloimmune Responses in Pediatric Kidney Recipients with Subclinical Vascular Injury.

    M. Seifert, M. Yanik, V. Hauptfeld-Dolejsek, R. Mannon.

    University of Alabama at Birmingham, Birmingham, AL

    Background: Antibodies to mismatched donor HLA antigens (DSA) have been associated with poor long-term outcomes in adult kidney recipients. We recently demonstrated a high prevalence…
  • 2016 American Transplant Congress

    Plasma Endothelial Microvesicle Counts Indicate Allograft Rejection Following Kidney Transplantation.

    D. Zecher,1 A. Cumpelik,2 B. Ruhland,1 B. Banas,1 H. Hopfer,3 M. Dickenmann,4 J. Schifferli.2

    1Nephrology, Regensburg University Hospital, Regensburg, Germany; 2Biomedicine, Basel University Hospital, Basel, Switzerland; 3Pathology, Basel University Hospital, Basel, Switzerland; 4Nephrology, Basel University Hospital, Basel, Switzerland.

    Background: The release of surface-derived microvesicles (MV) is a common phenomenon of cellular activation and occurs specifically as a consequence of terminal complement complex assembly…
  • 2016 American Transplant Congress

    Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.

    G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.

    Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

    Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
  • 2015 American Transplant Congress

    The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection

    J. Lee,1 J. Lee,1 B. Lim,2 B. Kim,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 H. Jeong,2 K. Park,4 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Pathology, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 4Department of Surgery, CHA Bundang Medical Center, Bundang, Republic of Korea.

    BackgroundThere have been marked advances of immunosuppression. However, management of late onset antibody-mediated rejection (AMR) after 6 months is still challenging. Despite important diagnostic and…
  • 2015 American Transplant Congress

    Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection

    T. Tsuji,1 M. Yanai,1 H. Itami,1 Y. Ishii,1 M. Akimoto,1 N. Fukuzawa,2 H. Harada,2 Y. Fukasawa.1

    1Demartment of Pathology, Sapporo City General Hospital, Sapporo, Japan; 2Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.

    Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…
  • 2015 American Transplant Congress

    High-Resolution Perfusion Mapping to Detect Heart Transplant Rejection Using Contrast Enhance Ultrasound

    K. Fischer,1,2 S. Ohori,2 F. Meral,1 S. Giannini,2 K. Hoffmeister,2 H. Athar,2 T. Ichimura,2 R. Smith,3 M. Giverts,2 F. Jolesz,1 R. Abdi.2

    1Radiology, Brigham and Women's Hospital, Boston; 2Medicine, Brigham and Women's Hospital, Boston; 3Pathology, Massachusetts General Hospital, Boston.

    Background: One of the key unmet needs in heart transplantation is an effective and accurate, non-invasive tool to diagnose acute and chronic heart transplant rejection.…
  • 2015 American Transplant Congress

    Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years

    A. Chapelet,1 M. Touzot,1 M. Fournier,2 A. Cesbron,3 K. Renaudin,4 A. Moreau,4 E. Morelon,5 D. Anglicheau,6 M. Giral.1

    1Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; 2EA 4275 SPHERE—Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, University of Nantes, Nantes, France; 3Etablissement Français du Sang (EFS), Nantes, France; 4Service d'Anatomie et Cytologie Pathologiques, CHU Nantes, Nantes, France; 5Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France; 6Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France.

    BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…
  • 2015 American Transplant Congress

    Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome

    P. Souza,1 D. Machado,1 D. David,1 G. Bezerra,1 F. Jota de Paula,1 H. Rodriges,2 W. Nahas,1 E. David Neto,1 M. Castro.1

    1Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; 2Lab de HLA, InCor, S Paulo, SP, Brazil.

    Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…

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