ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2020 American Transplant Congress

    Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG

    K. Lee1, C. Rickert1, K. Deng1, N. Feeney1, N. Tanimine2, Q. Fu1, G. Huai1, J. Lei1, C. Leguern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
  • 2020 American Transplant Congress

    Everolimus-Treatment Inhibits the Transition of the Immature Subsets of Liver Natural Killer Cells to Mature State and Enhances Anti-Tumor Activity

    Y. Tanaka, J. Saparbay, H. Ohdan

    Gastreenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation efficiently reduces the adaptive immune components. During suppressed adaptive immunity, the innate immune cells may play…
  • 2020 American Transplant Congress

    Role of Cross-Dressing in Kidney Transplantation

    D. Zhao, R. Tieu, K. Abou-Daya, A. Williams, M. Oberbarnscheidt, F. Lakkis

    Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Activation of host T cells that mediate allograft rejection is relied on dendritic cells (DCs) presenting alloantigens to T cells. Our recent study revealed…
  • 2020 American Transplant Congress

    Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model

    G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama

    Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    *Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
  • 2020 American Transplant Congress

    Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting Sting-Mediated NLRP3 Activation in Macrophages

    Z. Rao, W. Zhong, H. Zhou, P. Wang, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Aggravated liver injury and enhanced intrahepatic inflammation was found in old livers post ischemia and reperfusion (IR). However, the function and underlying mechanism of…
  • 2020 American Transplant Congress

    Role of Innate Allorecognition Pathways in Mouse Kidney and Heart Allograft Rejection

    D. Zhao1, H. Dai1, K. Abou-Daya1, R. Tieu1, A. Williams1, M. Oberbarnscheidt1, X. Li2, F. Lakkis1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX

    *Purpose: Paired immunoglobulin-like receptors (PIR) and CD47 are molecules expressed on host myeloid cells. They recognize donor polymorphic MHC and signal regulatory protein alpha (SIRPα),…
  • 2020 American Transplant Congress

    Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma

    K. Chinen, G. Yoshimatsu, N. Sakata, S. Kodama

    Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan

    *Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…
  • 2020 American Transplant Congress

    HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI

    S. Cai1, S. Wang2, W. Zhang2, A. Chandraker1, C. Yang2, T. Zhu2

    1Renal Division, Brigham and Women's Hospital, Boston, MA, 2Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
  • 2019 American Transplant Congress

    TDCA/Valine Reverse Obesity and Ameliorate Alloimmune Responses through a Decreased Hypothalamic Expression of MCH

    A. ElKhal1, M. Markus Quante1, T. Heinbokel1, Y. Nian1, K. Minami1, R. Maenosono1, J. Iske1, B. Desai2, A. Banks2, E. Maratos-Flier2, A. Elkhal1, S. G. Tullius1

    1Brigham and Women's Hospital, Boston, AL, 2Beth Israel Deaconess Medical Center, Boston, AL

    *Purpose: Obesity is associated with low grade inflammation and bariatric surgery is the only effective treatment in reducing excess weight both pre- and post-transplant.*Methods: Here,…
  • 2019 American Transplant Congress

    Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation

    D. P. Allen1, Z. Tu1, C. Wallace1, C. Li1, J. Kilkenny1, K. J. Patel1, D. Nord2, S. N. Nadig1, C. Atkinson2

    1Surgery, Medical University of South Carolina, CHARLESTON, SC, 2Microbiology & Immunology, Medical University of South Carolina, CHARLESTON, SC

    *Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…
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