ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2020 American Transplant Congress

    Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells

    B. Kim1, E. Kim2, J. Kim2, H. Choi3, H. Lee2, J. Lee4, M. Kim4, Y. Kim4, K. Huh4

    1Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of

    *Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
  • 2020 American Transplant Congress

    Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts

    V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
  • 2020 American Transplant Congress

    Serum CXCL13 Levels Indicate Humoral Alloreactivity and Donor Specific Antibody Formation

    E. S. Crichton, S. Zeng, I. Badell

    Emory University, Atlanta, GA

    *Purpose: Donor-specific antibodies (DSA) are an increasingly recognized cause of allograft injury, yet biomarkers to predict their development or guide their clinical management post-transplant are…
  • 2020 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
  • 2020 American Transplant Congress

    XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury

    H. Ni1, Y. Liu1, W. Deng1, J. Zhang2, J. Xu1, W. Zeng1, N. Gong2, Y. Miao1

    1Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…
  • 2020 American Transplant Congress

    CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel

    N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan

    Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…
  • 2020 American Transplant Congress

    A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse

    R. Plenter1, S. Jain2, J. J. Pomposelli1, T. Nydam1, A. Jani2

    1Pulmonary Division, University of Colorado, Aurora, CO, 2Renal Division, University of Colorado, Aurora, CO

    *Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…
  • 2020 American Transplant Congress

    The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses

    E. David1, M. Zhu2, W. Parker2, N. MacIver1, A. D. Kirk2, E. T. Chambers1

    1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC

    *Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…
  • 2019 American Transplant Congress

    Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia

    V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
  • 2019 American Transplant Congress

    Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation

    L. Qiu1, J. Wang1, X. Yeap1, C. Lin1, Y. S. Kanwar2, D. Fang2, M. M. Abecassis1, Z. J. Zhang1

    1Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, 2Department of Pathology, Northwestern University, Chicago, IL

    *Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…
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