Articles tagged "Mice"

2020 American Transplant Congress
The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation
V. Saxena, W. Piao, L. Hittle, L. Li, T. Simon, C. Palusckievicz, Y. Xiong, T. Zhang, M. Shirkey, E. F. Mongodin, J. S. Bromberg
University of Maryland, Baltimore, Baltimore, MD
*Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…
2020 American Transplant Congress
Identification of Cell Types That Harbor Cytomegalovirus DNA in Acutely and Latently Infected Mice Spleen
A. S. Maganti¹, X. Liu², M. Abecassis²
¹Illinois Math and Science Academy, Aurora, IL, ²Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: Cytomegalovirus (CMV) is a ubiquitous β‐herpesvirus that infects majority of humans. Primary CMV infection may be asymptomatic or manifests as a self‐limited febrile illness…
2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, K. Loh, J. Green, M. Sadat, M. Stovroff, A. Duttargi, B. Kallakury, K. Khan, T. Fishbein, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…
2020 American Transplant Congress
Microbiota Modulates Ischemia-Reperfusion Injury in Mouse Liver Transplantation
S. Kageyama¹, H. Kojima¹, K. Kadono¹, H. Hirao¹, K. J. Dery¹, K. Nakamura², T. Dong³, J. Jacobs³, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Nishi Kobe Medical Center, Kobe, Japan, ³The Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor in orthotopic liver transplantation (OLT). As host microbiota may associate with health or disease, antibiotics (Abx)…
2020 American Transplant Congress
Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease
J. Kim¹, D. Han¹, J. Jeong², J. Moon¹, S. Lee³, Y. Kim¹, K. Yoo⁴, D. Kim¹, Y. Kim¹, S. Yang¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Veterans Health Service Medical Center, Seoul, Korea, Republic of, ³Kangwon National University Hospital, Kangwon-do, Korea, Republic of, ⁴Ulsan National University Hospital, Ulsan, Korea, Republic of
*Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…
2020 American Transplant Congress
In-Depth Assessment of Ischemia/Reperfusion Injury in a Murine Model of Hindlimb Transplantation
F. Messner¹, K. Kadono², Y. Guo¹, B. Oh¹, J. Kupiec-Weglinski², G. Brandacher¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Surgery, Division of Liver and Pancreas Transplantation, University of California, Los Angeles, Los Angeles, CA
*Purpose: Static cold storage (SCS) still represents the gold standard for organ and tissue preservation in transplantation. Ischemia/reperfusion injury (IRI) that occurs due to the…
2020 American Transplant Congress
Reactivation of Murine Polyomavirus Replication by Renal Ischemia-Reperfusion Injury and Immunosuppression
G. Huang¹, Y. Huang¹, X. Chen¹, J. Qiu¹, J. Li¹, G. Li², C. Wang¹, L. Chen¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Guangdong Key Laboratory of Laboratory Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China
*Purpose: Polyomavirus (PyV) nephropathy is an important cause of graft failure after renal transplantation. Its pathogenesis is associated with immunosuppression (IM) and renal ischemia-reperfusion injury…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Cervical Total Arterial Anastomosis Mouse-to-Rat Heterotopic Heart Xenotransplantation
A. Ren, Z. Li, X. Zhang, R. Deng, Y. Ma
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Xenotransplantation is an effective way to solve the problem of donor shortage. However, clinical use of xenotransplantation is currently limited due to immunological challenges.…
2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…

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