ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2021 American Transplant Congress

    Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MD

    *Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
  • 2021 American Transplant Congress

    The Gut Microbiotainduces Local and Systemic Immune Modulation

    V. Saxena, R. Lakhan, J. Iyyathurai, W. Piao, L. Li, T. Zhang, M. W. Shirkey, B. Ma, E. F. Mongodin, J. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…
  • 2021 American Transplant Congress

    Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival

    B. W. Wong, Y. Zhu, H. Dun, L. Ye

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
  • 2020 American Transplant Congress

    Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells

    B. Kim1, E. Kim2, J. Kim2, H. Choi3, H. Lee2, J. Lee4, M. Kim4, Y. Kim4, K. Huh4

    1Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of

    *Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
  • 2020 American Transplant Congress

    Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts

    V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
  • 2020 American Transplant Congress

    Serum CXCL13 Levels Indicate Humoral Alloreactivity and Donor Specific Antibody Formation

    E. S. Crichton, S. Zeng, I. Badell

    Emory University, Atlanta, GA

    *Purpose: Donor-specific antibodies (DSA) are an increasingly recognized cause of allograft injury, yet biomarkers to predict their development or guide their clinical management post-transplant are…
  • 2020 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
  • 2020 American Transplant Congress

    XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury

    H. Ni1, Y. Liu1, W. Deng1, J. Zhang2, J. Xu1, W. Zeng1, N. Gong2, Y. Miao1

    1Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…
  • 2020 American Transplant Congress

    CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel

    N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan

    Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…
  • 2020 American Transplant Congress

    A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse

    R. Plenter1, S. Jain2, J. J. Pomposelli1, T. Nydam1, A. Jani2

    1Pulmonary Division, University of Colorado, Aurora, CO, 2Renal Division, University of Colorado, Aurora, CO

    *Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…
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