2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…2020 American Transplant Congress
Liver Plasmacytoid Dendritic Cells Express High Levels of DAP12, TREM2 and PD-L1 and Promote Effector T Cell Exhaustion and Augmented Treg Responses in Spontaneous Liver Transplant Tolerance
University of Pittsburgh, Pittsburgh, PA
*Purpose: The precise mechanisms of liver transplant tolerance are yet to be elucidated. Non-conventional plasmacytoid dendritic cells (pDCs) are thought to promote immune regulation, including…2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…2020 American Transplant Congress
Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment
*Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…2020 American Transplant Congress
Treatment Strategies to Suppress Donor Specific Antibodies: Highlights from a Decade of Research Experience in a Mouse Model of Allo-Sensitization
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Difficulty in desensitization in highly sensitized patients remain problematic in organ transplantation. For over 12 years, our laboratory has been carrying out an HLA…2020 American Transplant Congress
Long-Term Allograft Survival via Donor MHC Chimerism Induced by Exosomes
*Purpose: Allogeneic transplant tolerance has been achieved by inducing mixed hematopoietic chimerism via donor bone marrow transplantation. Tolerance mechanisms in this model involve the presentation…2020 American Transplant Congress
Graft Perfusion with an Hsp90 Inhibitor Prolongs Graft Survival in Murine Heart Transplantation by Modulating Expression of Cyclin-Dependent Kinases and the Senolytic Effect
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of alvespimycin, a heat shock protein 90 (HSP90) inhibitor, prolongs the allograft survival in murine skin and heart…2020 American Transplant Congress
The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation
University of Maryland, Baltimore, Baltimore, MD
*Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…
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