ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2016 American Transplant Congress

    2B4 Over-Expression Impairs Donor-Reactive CD8+ T Cell Proliferation and Accumulation Following Transplantation.

    S. Laurie, D. Liu, M. Ford.

    Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.

    T cell function is tightly regulated by a fine balance of coinhibitory signals, including those transduced by 2B4 (SLAMf4, CD244), an immunoglobulin-superfamily member constitutively expressed…
  • 2016 American Transplant Congress

    Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.

    L. Margoles, S. Laurie, C. Coopersmith, M. Ford.

    Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.

    Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…
  • 2016 American Transplant Congress

    Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.

    T. Thornley,1 P. Kyriazis,1 K. Agarwal,1 Z. Fang,1 L. Ma,1 V. Chipashvili,1 M. Koulmanda,1,2 T. Strom.1,2

    1Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; 2Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA.

    We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…
  • 2016 American Transplant Congress

    Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.

    M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.

    Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.

    PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
  • 2015 American Transplant Congress

    In Vivo Expansion of Donor-Specific Regulatory T Cells by a New Triazolopyrimidine Derivative and Donor-Specific Transfusion

    S. Emoto,1 R. Goto,1 S. Shibasaki,1 A. Nagatsu,1 H. Ono,1 R. Igarashi,1 M. Fukai,2 T. Shimamura,3 K. Saiga,4 M. Murakami,5 A. Taketomi,1 S. Todo,6 K. Yamashita.2

    1Gastroenterological Surgery 1, Hokkaido University, Sapporo, Japan; 2Transplant Surgery, Hokkaido University, Sapporo, Japan; 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan; 4Nippon Kayaku, Tokyo, Japan; 5Institute for Genetic Medecine, Hokkaido University, Sapporo, Japan; 6Research Institute, St. Mary Hospital, Kurume, Japan.

    Background: We have previously demonstrated that a new triazolopyrimidine derivative, NK026680 (NK) prevents activation/maturation of dendritic cells. This study investigated whether NK together with donor-specific…
  • 2015 American Transplant Congress

    Evaluation of the Gastrointestinal Tract as a Potential Route of Primary Polyomavirus Infection

    G. Huang,1 G. Zeng,2 Y. Huang,2 P. Randhawa.2

    1Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Detection of Polyomavirus(Py) DNA in metropolitan river water worldwide has led to the suggestion that primary viral infection can occur by the oral route. The…
  • 2015 American Transplant Congress

    Ischemia-Induced Endoplasmic Reticulum Stress Regulates Autophagy to Determine the Severity of Liver Ischemia Reperfusion Injury

    H. Zhou,1,2 J. Zhu,1 S. Yue,1 R. Busuttil,1 J. Kupiec-Weglinski,1 Y. Zhai.1

    1The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA; 2Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

    Both endoplasmic reticulum (ER) stress and autophagy have been implicated in the pathogenesis of ischemia and reperfusion injury (IRI). As essential cellular stress responses against…
  • 2015 American Transplant Congress

    Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model

    T. Kwan,1,2 S. Chadban,1,2 J. Ma,1,2 S. Bao,2,3 S. Alexander,2,4 H. Wu.1,2

    1Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; 2Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; 3Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; 4Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

    Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
  • 2015 American Transplant Congress

    Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses

    V. Agashe,1 M. Keller,2 L. Haynes,1 E. Jankowska-Gan,1 J. Sullivan,1 J. Kernien,1 H. Suzuki,3 D. Wilkes,4 W. Burlingham.1

    1Surgery, UW Madison, Madison, WI; 2Tulane University, New Orleans, LA; 3Chiba Graduate School of Medicine, Chiba, Japan; 4Indiana University School of Medicine, Indianapolis, IN.

    Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
  • 2015 American Transplant Congress

    Emerging Application of Active Immune Targeted Delivery in Transplantation

    M. Uehara,1 A. Jamil,1 M. McGrath,1 Z. Solhjou,1 N. Banouni,1 S. Tullius,2 C. Jianjun,3 R. Abdi.1

    1Renal Division, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical Shcool, Boston, MA; 2Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA; 3Materials Science and Engineering, University of Illinois at Urbana-Champaign, Champaingn, IL.

    Targeted nanodelivery has created enormous excitement as a transformative approach to deliver therapeutics to tissues of interest. In recent years, we have made significant progress…
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