Articles tagged "Mice"

2016 American Transplant Congress
The Role of B Cells in Liver Transplant Tolerance.
M. Morita,² G. Enyindah-Asonye,¹ N. Gupta,¹ J. Fung,² S. Qian,^1,2 L. Lu.^1,2
¹Immunology, LernerResearch Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Scarcely one would argue that donor-specific B cells and antibodies contribute to rejection of transplants. However, studies published in the past few years have provided…
2016 American Transplant Congress
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Protects Against Loss of Hepatic Integrity After Ischemia-Reperfusion Injury.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix (ECM)-associated protein…
2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
B. Stocks, C. Wilson, D. Meehan, A. Marshall, D. Moore.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
2016 American Transplant Congress
Novel Function of CD4⁺ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
J. Wedel,^1,2 S. Bruneau,^1,2 K. Liu,^1,2 N. Kochupurakkal,^1,2 M. Laplante,³ D. Briscoe.^1,2
¹Division of Nephrology, Boston Children's Hospital, Boston, MA; ²Transplant Research Program, Harvard Medical School, Boston, MA; ³CRIUCPQ, Université Laval, Quebec, Canada.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
M. Sabet-Baktach,¹ E. Eggenhofer,¹ P. Renner,¹ M. Lantow,¹ H. Schlitt,¹ E. Geissler,¹ A. Kroemer.^1,2
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
2015 American Transplant Congress
CD8⁺TCR^– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
Y. Wen,¹ Y. Huang,¹ T. Miller,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
2015 American Transplant Congress
Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Medicine, University of Minnesota, Minneapolis, MN; ²Surgery and Immunology, University of Colorado Denver, Aurora, CO.
In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…
2015 American Transplant Congress
Effectiveness of Neovascularization Surrounding Engrafted Islets by Matrigel With Additional Growth Factors in Intramuscular Islet Transplantation
G. Yoshimatsu,^1,2 N. Sakata,² H. Tsuchiya,² M. Takita,³ M. Levy,³ B. Naziruddin,³ M. Unno.²
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Intramuscular islet transplantation is one of the promising transplant sites because of safety, easy accessibility and less invasive procedure. However the efficacy of the…
2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹
¹Department of Surgery, Teikyo University, Tokyo, Japan; ²Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Department of Immunology, Juntendo University Hospital, Tokyo, Japan; ⁵Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…