ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2016 American Transplant Congress

    Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.

    J. Rao,1 H. Zhou,1 F. Zhang,1 X. Wang,1 Y. Zhai,2 L. Lu.1

    1Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.

    Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…
  • 2016 American Transplant Congress

    Role of NRP1 in CD4+ T Cell Allo-Activation.

    E. Lee, H. Kim, G. Demirci.

    Department of Surgery, Boston Children's Hospital, Boston, MA.

    Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
  • 2016 American Transplant Congress

    Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.

    S. Goparaju, R. Fan, K. Keslar, N. Dvorina, W. Baldwin III.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Fat is now recognized as a source of immunologically significant cytokines. Adiponectin, the most abundant adipokine, is usually classified as an anti-inflammatory cytokine because decreased…
  • 2016 American Transplant Congress

    IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.

    P. Chhabra, R. Gehrau, V. Mas, D. Bower, D. Maluf, K. Brayman.

    UVA, Charlottesville.

    Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…
  • 2016 American Transplant Congress

    Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8+ T Cell Responses.

    A. Karp, M. Wagener, J. Robertson, M. Ford.

    Emory University, Atlanta.

    The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…
  • 2016 American Transplant Congress

    Imaging Cell Biology In Vivo with Intravital-Microscopy.

    T. Ueno,1 M. Yeung,1 N. Igarashi,3 T. Yokoyama,2 Y. Kihara,2 O. Konno,2 Y. Nakamura,2 H. Iwamoto,2 T. Ikeda,3 M. McGrath,1 M. Sayegh,1 A. Chandraker.1

    1Renal Division, Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; 2Transplant Surgery, Tokyo Medical Univ., Hachioji, Tokyo, Japan; 3Intensive Care Medicine, Tokyo Medical Univ., Hachioji, Tokyo, Japan.

    Background: Despite current immunosuppressive therapy, many recipients endure multiple episodes of acute rejection. The interplay between dendritic cells (DCs) and T cells plays a central…
  • 2016 American Transplant Congress

    Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.

    A. Thorenz,1 R. Chen,1 K. Hueper,2 B. Hensen,2 C. Klemann,3 M. Meier,4 A. Klos,5 F. Gueler.1

    1Nephrology, Medical School, Hannover, Germany; 2Radiology, Medical School, Hannover, Germany; 3Paediatric Surgery, Medical School, Hannover, Germany; 4Central Animal Facility, Medical School, Hannover, Germany; 5Microbiology, Medical School, Hannover, Germany.

    ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
  • 2016 American Transplant Congress

    Successful Treatment of Established Acute Allograft Rejection with Delayed CTLA-4Ig.

    J. Young,1 J. Chen,1 D. Yin,1 R. Sciammas,2 V. Vu,1 M.-L. Alegre,3 A. Chong.1

    1Transplant Surgery, University of Chicago, Chicago, IL; 2Medicine, Houston Methodist Research Institute, Houston, TX; 3Medicine, University of Chicago, Chicago, IL.

    Purpose: Our goal was to determine the efficacy and immune mechanisms of costimulation blockade by CTLA-4Ig when treatment begins after an immune response is already…
  • 2016 American Transplant Congress

    Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.

    J. Marino,1 J. Paster,1 P. Crosby,1 M. Uehara,2 S. Mordecai,1 R. Abdi,2 G. Tocco,1 G. Benichou.1

    1Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA; 2Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA.

    We have studied the trafficking of donor passenger leukocytes and donor MHC presentation in the lymphoid organs of mice having received an MHC-mismatched skin or…
  • 2016 American Transplant Congress

    Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
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