Articles tagged "Mice"

2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
T. Thornley,¹ P. Kyriazis,¹ K. Agarwal,¹ Z. Fang,¹ L. Ma,¹ V. Chipashvili,¹ M. Koulmanda,^1,2 T. Strom.^1,2
¹Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…
2016 American Transplant Congress
Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
2016 American Transplant Congress
Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.
T. Maehana,¹ T. Tanaka,¹ H. Kitamura,² N. Masumori.¹
¹Urology, Sapporo Medical University School of Medicine, Sapporo, Japan; ²Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.
Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…
2016 American Transplant Congress
Tracking of Endogenous Graft-Reactive Tregs Reveals Their Peripheral Enrichment During Transplantation Tolerance.
J. Young,¹ J. Chen,¹ M. Miller,¹ D. Yin,¹ J. Moon,² M.-L. Alegre,¹ A. Chong.¹
¹Surgery and Medicine, University of Chicago, Chicago, IL; ²Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA.
Purpose: Our goal for this study was to determine the relative fates of endogenous Foxp3- conventional (Tconv) and Foxp3+ regulatory T cells (Tregs) specific for…
2016 American Transplant Congress
Toll-Like Receptor (TLR) 9-Induced Resistance to Murine Cardiac Allograft Tolerance Is Dependent Upon C3a and C5a Receptor (C3aR/C5aR) Signaling.
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR stimulation has been shown by others to prevent costimulatory blockade-induced allograft tolerance. Immune cell derived complement activation products C3a and C5a amplify inflammation, enhance…
2016 American Transplant Congress
Aging Is Critically Impacting the Efficacy of Immunosuppressants.
J. Schuitenmaker, K. Edtinger, M. Seyda, H. Uehara, M. Quante, A. ElKhal, S. Tullius.
Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Immunosenescence is broadly affecting alloimmunity with major implications on immunosuppression. Older recipients have thus far been mostly excluded from clinical trials. Here, we dissected the…
2016 American Transplant Congress
Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.
D. Mathern, P. Heeger.
Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
2016 American Transplant Congress
C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.
I. Llaudo, P. Conde, J. Ochando, P. Heeger.
Icahn School of Medicine at Mount Sinai, New York, NY.
Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…
2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
B. Motyka,¹ B. Lamarche,¹ K. Labonte,¹ S. Wang,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹
¹Alberta Transplant Institute/CNTRP, University of Alberta, Edmonton, Canada; ²Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
2016 American Transplant Congress
Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.
B. Stocks, C. Wilson, M. Seto, A. Marshall, D. Moore.
Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…