Articles tagged "Mice"

2017 American Transplant Congress
Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.
L. Kojima,¹ S. Kimura,^1,2 K. Lee,¹ C. Schuetz,¹ L. Washburn,¹ K. Deng,¹ H. Tector,¹ B. Amundsen,^1,2 D. Ndishabandi,^1,2 A. Markmann,¹ M. Markmann-Porch,¹ T. Oura,¹ A. Alessandrini,^1,2 J. Kim,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA
Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…
2017 American Transplant Congress
Combining Neural Stem Cell Transplantation with Mixed Hematopoietic Chimerism Promotes Restoration of Self-Tolerance in Established Experimental Autoimmune Encephalomyelitis.
W. Orent, J. Marino, B. Gonzalez Nolasco, J. Paster, A. Harney, D. Sachs, G. Benichou.
Surgery, Massachusetts General Hospital, Boston, MA
Multilineage mixed hematopoietic chimerism induces tolerance to alloantigens in rodents, large animals and kidney-transplanted patients. Here we combined mixed chimerism with neural stem cell (NSC)…
2017 American Transplant Congress
Persistent Donor Antigen Leads to Dysfunctional CD4⁺Memory T Cell Development.
M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹
¹Medicine, University of Chicago, Chicago, IL; ²Surgery, University of Chicago, Chicago, IL; ³Chicago State University, Chicago, IL; ⁴Institute for Molecular Engineering, University of Chicago, Chicago, IL; ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
Tolerance to alloantigens is characterized by low alloreactive T cell responses upon restimulation with donor antigens, a state that can result from deletion of donor-specific…
2017 American Transplant Congress
Transplantation of Chimeric Cells of Myoblast and Mesenchymal Stem Cell Origin for Restoration of Muscle Function.
M. Siemionow, E. Szilagyi, J. Cwykiel, A. Domaszewska-Szostek, A. Heydemann, J. Garcia-Martinez.
University of Illinois at Chicago, Chicago
Background: Allogeneic stem cell therapies aim to restore muscle tissue after traumatic loss or muscular dystrophies. Limited engraftment due to rejection is a major challenge.…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
M. Climov, M. Uehara, Z. Solhjou, H. Matsumine, N. Bouyani, E. Kefaloyianni, B. Basmani, V. Kasinath, G. Giatsidis, D. Orgill, R. Abdi.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…
2017 American Transplant Congress
TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…
2017 American Transplant Congress
Identification of Novel Diagnostic Biomarkers in Liver Transplantation Tolerance.
G.-Q. Shen,¹ M. Morita,¹ C. Miller,¹ K. Hashimoto,¹ L. Lu,¹ S. Qian,¹ J. Fung.²
¹Cleveland Clinic, Cleveland; ²University of Chicago, Chicago
Current success in liver transplantation (LTX) relies on life-time administration of non-specific immunosuppressive drugs, leaving patients prone to infection and cancer. Previous reports indicated about…
2017 American Transplant Congress
Effects of Tofacitinib (JAK-3 Inhibitor) on De Novo HLA-A2 Antibody Production in a Mouse Model of Allo-Sensitization.
N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: Tofacitinib is a Janus Kinase Inhibitor currently approved by FDA for treatment of rheumatoid arthritis. In considering its effect in reducing B cell proliferation…
2017 American Transplant Congress
Clinically Relevant Immunosuppression Promotes MCMV Reactivation and Dissemination Following Transplantation of Latently Infected Kidneys.
Z. Zhang,¹ S. Yan,¹ L. Zhao,¹ S. Kurian,² M. Hummel,¹ D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago; ²Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla
Reactivation of latent Cytomegalovirus (CMV) is an important problem facing clinical transplantation. We have previously described a model for murine CMV (MCMV) reactivation following kidney…