2018 American Transplant Congress
Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function
Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.
Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…2018 American Transplant Congress
Alveolar Macrophages Derived from MCMV Latently Infected Donors Drives the Viral Reactivation and Dissemination Following the Orthotopic Left Lung Transplantation in Mice
Background: The incidence of cytomegalovirus (CMV) disease is higher in lung transplants, than in other SOT recipients, especially in high-risk D+/R- recipients. Using a murine…2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…2018 American Transplant Congress
TLR-Activated Bregs Promote Islet Allograft Tolerance in an IL-10-Independent and TGF-β-Dependent Manner
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We previously demonstrated the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. Recently, we produced TLR-activated B cells in vitro that…2018 American Transplant Congress
Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival
Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…2018 American Transplant Congress
Multi-Targeting Desensitization Therapy Alters Peripheral B-Cell Homeostasis and Suppresses Recall Alloantibody Responses
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Occurring of donor specific antibodies (DSA) is injurious to organ transplant. Development of immunotherapies to suppress DSA, therefore, has been one of the strategic…2018 American Transplant Congress
APRIL/BLyS Blockade Improves Depletion of Antibody Secreting B Cells Compared to BLyS Blockade Alone in Sensitized Murine Kidney Transplant Model
1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) remains a significant problem in highly sensitized individuals undergoing kidney transplantation. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte…2018 American Transplant Congress
In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice
Surgery, Duke University, Durham, NC.
Mitochondria released in the setting of tissue injury are a source of damage associated molecular patterns (DAMPs) that initiate innate immune responses. We hypothesized that…
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