Articles tagged "Mice"

2018 American Transplant Congress
Prolonged Cold Ischemia Storage of Renal Allografts Shifts DSA Specificity and Enchances Glomerular Injury
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor organs is a major risk factor for acute and chronic graft injury. The goal of this study was…
2018 American Transplant Congress
ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells
B. Motyka,¹ J. Fersovich,¹ B. Lamarche,¹ M. Sosniuk,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, University of Alberta, Edmonton, Canada; ³St Vincent's Hospital, Melbourne, Australia.
Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
2018 American Transplant Congress
Immune Modulatory Effect of Thalidomide and Dexamethasone Co-Treatment on Murine Splenocytes
E. Kim,^1,2 J. Kim,¹ K. Huh,^1,3 Y. Cho,¹ M. Kim,^1,3 Y. Kim,^1,3 B. Kim.^1,4
¹The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ²Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea; ³Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Internal Medicine, Nephrology, Yonsei University College of Medicine, Seoul, Korea.
Thalidomide (TM) is known to have anti-inflammatory effects and dexamethasone (DX) is also well known to reduce inflammation and inhibit inflammatory cytokine production. Clinically, combinatorial…
2018 American Transplant Congress
Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv
J. Young, D. Yin, M-.L. Alegre, A. Chong.
Surgery and Medicine, University of Chicago, Chicago, IL.
Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…
2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
A. Cherry,¹ K. Porter,¹ H. Suliman,¹ J. Wang,² M. Mulvihill,² A. Kirk.²
¹Anesthesiology, Duke University, Durham, NC; ²Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
2018 American Transplant Congress
T-bet and STAT6 Double Deficiency Favors IL-17 Immunity after Lung Transplantation
F. Liang,¹ R. Chen,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: The long-term success of lung transplantation is mainly limited by the development of obliterative bronchiolitis (OB) in which IL-17 plays a critical role. Direct…
2018 American Transplant Congress
Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands
A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.
Transplant Surgery, University of Wisconsin, Madison, WI.
The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…
2018 American Transplant Congress
Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart Transplantation
K. Uchida, K. Fujimoto, K. Takeda, H. Bashuda, E. Yin, K. Okumura.
Atopy(Allergy) Research Center, Juntento University, Tokyo, Japan.
Purpose: To investigate the impact of BM-MDSCs on murine heart transplantationMaterial and Methods:Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and…
2018 American Transplant Congress
The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance
W. Burlingham,¹ J. Sullivan,¹ D. Lema,¹ Y. Tomita,² Y. Zhou,¹ D. Vignali.³
¹Surgery, University of Wisconsin, Madison, WI; ²Surgery, Tokyo Women's Hospital, Tokyo, Japan; ³Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.
The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…