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Articles tagged "Metalloproteinases"

  • 2019 American Transplant Congress

    Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury

    S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…
  • 2018 American Transplant Congress

    Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury

    S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.

    Dumont-UCLA Transplant Center, Los Angeles.

    Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
  • 2016 American Transplant Congress

    Matrix Metalloproteinase-9 in Human Orthotopic Liver Transplant Biopsies.

    S. Duarte, N. Datta, J. Baber, R. Busuttil, A. Zarrinpar, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Liver ischemia reperfusion injury (IRI) is an inflammatory event that contributes to graft dysfunction in orthotopic liver transplantation (OLT). Matrix Metalloproteinases (MMPs) are responsible for…
  • 2016 American Transplant Congress

    Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.

    S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…
  • 2016 American Transplant Congress

    Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.

    S. Duarte, P. Matian, H. Kato, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…
  • 2015 American Transplant Congress

    AAV-Mediated TIMP-1 Gene Therapy Ameliorates Hepatic Ischemia/Reperfusion Injury

    S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…

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