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Articles tagged "Metalloproteinases"

  • 2022 American Transplant Congress

    Study Of Matrix Metalloproteinases(MMP) And Tissue Inhibitors Of Metalloproteinases(TIMP) In Renal Transplant Recipients(RTR)- Rejectors Versus Stable Graft

    J. P. Tom1, R. Dhital2, A. Sharma3, R. Aggarwal1, R. Nada4, R. Ramachandran5, S. Anand1, M. Minz6, R. Minz1

    1Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 2Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, 3Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 4Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 5Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 6Department of Renal Transplant Surgery, Fortis Hospital, Mohali, Mohali, India

    *Purpose: Our study aimed to shed light on the role of serum levels of MMP and their inhibitors- TIMP in renal allograft rejection.*Methods: This was…
  • 2022 American Transplant Congress

    Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome

    J. P. Tom1, J. Singh1, A. Sharma2, R. Aggarwal1, R. Nada3, R. Ramachandran4, S. Anand1, R. Minz1

    1Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 2Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 3Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 4Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    *Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…
  • 2019 American Transplant Congress

    Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury

    S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…
  • 2018 American Transplant Congress

    Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury

    S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.

    Dumont-UCLA Transplant Center, Los Angeles.

    Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
  • 2016 American Transplant Congress

    Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.

    S. Duarte, P. Matian, H. Kato, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…
  • 2016 American Transplant Congress

    Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.

    S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…
  • 2016 American Transplant Congress

    Matrix Metalloproteinase-9 in Human Orthotopic Liver Transplant Biopsies.

    S. Duarte, N. Datta, J. Baber, R. Busuttil, A. Zarrinpar, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Liver ischemia reperfusion injury (IRI) is an inflammatory event that contributes to graft dysfunction in orthotopic liver transplantation (OLT). Matrix Metalloproteinases (MMPs) are responsible for…
  • 2015 American Transplant Congress

    AAV-Mediated TIMP-1 Gene Therapy Ameliorates Hepatic Ischemia/Reperfusion Injury

    S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…

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