ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "marginal"

  • 2018 American Transplant Congress

    Kidney Transplantation in Older Recipients: Preemptive High KDPI Kidney vs. Lower KDPI Kidney after Varying Dialysis Vintage

    B. Chopra, S. Hussain, K. Sureshkumar.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    Dialysis vintage is an independent predictor of adverse long-term kidney transplant outcomes. Transplantation of "marginal" kidneys also results in inferior outcomes. We sought to analyze…
  • 2018 American Transplant Congress

    Viability Outcomes for Donor Livers Discarded Due to Steatosis Following Extra-Corporeal Machine Perfusion of the Liver

    Y. Boteon,1,2 R. Laing,1,2 D. Neil,2 A. Schlegel,2 J. Attard,1,2 G. Reynold,1 P. Muiesan,2 D. Mirza,2 S. Afford,1 H. Mergental.2

    1National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; 2Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.

    Background: Steatosis is the main reason for discarding donor livers worldwide. Ex-vivo machine perfusion offers superior preservation for marginal organs and permits viability testing during…
  • 2018 American Transplant Congress

    Pre-Existing Allograft Diabetic Nephropathy from Diabetic Donor is Reversible after Kidney Transplantation in Non-Diabetic Recipient

    K. Hotta,1 D. Iwami,1 H. Harada,2 Y. Fukasawa,2 H. Okada,1 H. Higuchi,1 T. Hirose,2 N. Fukuzawa,2 N. Shinohara.1

    1Hokkaido University Hospital, Sapporo, Japan; 2Sapporo City General Hospital, Sapporo, Japan.

    【Introduction】The shortage of kidney donor has limited the treatment of patients with end-stage kidney disease. To use diabetic donor with normal renal function is would…
  • 2018 American Transplant Congress

    Discard and Post-Transplant Outcomes Associated with Organs Donated after Drug-Overdose Death

    M. Bowring, C. Durand, L. Kucirka, A. Thomas, A. Massie, M. Sulkowski, A. Cameron, N. Desai, D. Segev.

    JHU, Baltimore.

    The United States faces an overdose epidemic primarily affecting young adults who might represent a novel source of viable deceased-donor organs. Utilization and outcomes associated…
  • 2018 American Transplant Congress

    Impact of ELAD C3A Cell Conditioned Medium Enhanced Perfusate Fluid on Functional Recovery of Extended Criteria Donor Livers during Normothermic Machine Perfusion

    S. Afford,2 L. Wallace,2 R. Laing,2 Y. Botteon,2 D. He,3 S. Soundararajan,4 D. Mirza,1 R. Ashley,3 J. Brotherton,3 H. Mergental,1 D. Reich.4

    1Queen Elizabeth Hospital, Birmingham, United Kingdom; 2University of Birmingham, Birmingham, United Kingdom; 3Vital Therapies Inc, San Diego, CA; 4Drexel University, Philadelphia.

    Reconditioning of donor livers by Normothermic Machine Perfusion (NMP) is already increasing the numbers of transplantable organs from the extended criteria donors. The hepatoblastoma-derived cell…
  • 2018 American Transplant Congress

    Evolution of Very Old Donor Grafts

    S. Jiménez Alvaro,1 A. Fernández Rodriguez,1 C. Galeano Alvarez,1 S. Elías Treviño,1 J. Burgos,2 F. Liaño García.1

    1Nephrology, Hospital Ramón y Cajal, Madrid, Spain; 2Nephrology, Hospital Ramón y Cajal, Madrid, Spain; 3Nephrology, Hospital Ramón y Cajal, Madrid, Spain; 4Nephrology, Hospital Ramón y Cajal, Madrid, Spain; 5Urology, Hospital Ramón y Cajal, Madrid, Spain; 6Nephrology, Hospital Ramón y Cajal, Madrid, Spain.

    Introduction: The need to implement the pool of donors has led to the use of organs from older donors, as has been described in several…
  • 2018 American Transplant Congress

    A Phase I/II, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients

    S. Jordan,1 J. Choi,1 O. Aubert,2 M. Haas,3 A. Loupy,2 E. Huang,1 A. Peng,1 I. Kim,1 S. Sethi,1 S. Louie,1 D. Puliyanda,1 A. Vo.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France; 3Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: Delayed graft function (DGF)in kidney allograft recipients is traditionally defined as need for dialysis during the first week after transplantation. DGF is related to…
  • 2018 American Transplant Congress

    Evaluation of Accepting Kidneys of Varying Quality for Transplantation or Expedited Placement with Decision Trees

    S. Mehrotra,1 H. Gordon,1 K. Bui,1 J. Friedewald,2 D. Ladner,2 B. Kaplan,4 V. Kilambi.3

    1Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL; 2Feinberg School of Medicine, Northwestern University, Chicago, IL; 3Operations Research, RAND Corporation, Boston, MA; 4Transplant Services, Baylor Scott and White, Houston, TX.

    Underutilization of marginal-quality kidney-organs for transplantation has occupied the community and led to introducing the idea of expediting the placement of kidneys for populations at…
  • 2018 American Transplant Congress

    QPI-1002, a siRNA Targeting p53: Improvement in Outcomes Following Acute Kidney Injury (AKI): Cardiac Surgery to AKI Donors

    J. Tchervenkov,2 E. Squiers,1 R. Stratta,3 D. Odenheimer,2 D. Rothenstein,2 QPI-1002 DGF Study Group.

    1Quark Pharmaceuticals, Fremont; 2McGill University Health, Montreal, Canada; 3Wake Forest School of Medicine Centre, Winston-Salem.

    Background: QPI-1002 has been observed to statistically reduce the incidence, severity and duration of AKI in a large Phase 2 study of AKI following cardiac…
  • 2018 American Transplant Congress

    The Use of LiMAx for Evaluating Donor Livers on Normothermic Machine Perfusion

    J. Schurink,1 J. de Haan,2 M. Verstegen,1 H. Metselaar,3 J. Ijzermans,1 J. de Jonge.1

    1Surgery, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; 2Intensive Care Medicine, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; 3Gastroenterology, Erasmus MC, Rotterdam, Zuid Holland, Netherlands.

    Due to the organ shortage, inferior quality livers from donors after circulatory arrest (DCD) are offered to relieve mortality on the waiting list. The threshold…
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