Articles tagged "marginal"

2015 American Transplant Congress
Donor-Derived Tumor Transmission Events. A Summary of 2008-2013 Data from the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
M. Nalesnik,¹ S. Taranto,² S. Covington,² E. Blumberg,¹ M. Green,¹ T. Gross,¹ M. Klassen-Fischer,¹ M. Pavlakis,¹ C. Wolfe,¹ D. Kaul.¹
¹OPTN Disease Transmission Advisory Committee (DTAC), Richmond, VA; ²United Network for Organ Sharing, Richmond, VA.
Purpose: Transmission of donor malignancy via transplantation is an uncommon but significant occurrence. The OPTN Disease Transmission Advisory Committee (DTAC) has monitored such complications since…
2015 American Transplant Congress
Where Does It End? Outcome of the Rejected Kidney Offers for Potential Renal Transplant and Their Outcome. A Single Centre Experience
A. Ghazanfar, M. Al Azeez, M. Morsy, A. Bagul.
Renal Medicine and Transplant Surgery, St Georges Healthcare NHS Trust, London, United Kingdom.
Background: Worldwide there are no uniformly acceptable deceased donor selection criteria for renal transplantation. There are national and international guidelines available based on which most…
2015 American Transplant Congress
Histopathological Criteria for Elevated Risk of Delayed Graft Function in German Pretransplantation Kidney Biopsies from Deceased Donors
J. Becker,¹ B. Eggers,² P. Mertens,³ A. Schwarz,⁴ C. Chatzikyrkou.³
¹Institute of Pathology, University Hospital of Cologne, Cologne, North Rhine-Westfalia, Germany; ²Deutsche Stiftung Organtransplantation, Frankfurt, Hesse, Germany; ³Department of Nephrology and Hypertension, Diabetology and Endocrinology, University Hospital of Magdeburg, Magdeburg, Saxonia-Anhalt, Germany; ⁴Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Lower Saxony, Germany.
Introduction:Delayed graft function (DGF) is more frequent with so called marginal kidney donors. Moreover, it is linked to increased recipient mortality and inferior transplant outcome.…
2015 American Transplant Congress
A Prospective Comparison of the Completeness of Donor Kidney Biopsies
S. Ahmad,¹ E. Siskind,¹ C. Drachenberg,² J. Bromberg,¹ S. Niederhaus.¹
¹Transplantation, University of Maryland, Baltimore; ²Pathology, University of Maryland, Baltimore.
Background: The use of expanded criteria kidneys has plateaued, possibly due to inadequate pathologic evaluation or lack of a universal grading system. We examined pre-transplant…
2015 American Transplant Congress
Detriemental Impact of DGF and CIT On Longterm Survival After Kidney Transplantation in Elderly Recipients
C. Denecke,^1,2 M. Biebl,^1,2 C. Bösmüller,² F. Aigner,^1,2 T. Dziodzio,^1,2 R. Sucher,^1,2 S. Weiss,² J. Pratschke,^1,2 R. öllinger.^1,2
¹Allgemein, Viszeral – und Transplantationschirurgie, Charite Virchow Klinikum, Berlin, Germany; ²Viszeral, Transplantations – und Thoraxchirurgie, Medizinische Universität Innsbruck, Innsbruck, Austria.
Background: In kidney transplantation, the association of cold ischemia time (CIT) and delayed graft function (DGF) is particularly detriemental in grafts from marginal donors. In…
2015 American Transplant Congress
One Year Outcomes and Quality of Life Measurements in 127 Extended Criteria Donor Recipients- A Single Centre Comparative Study
Y. Tabbakh,¹ S. Turner,¹ H. Maple,¹ C. Callaghan,¹ J. Olsburgh,¹ F. Calder,¹ M. Drage,¹ N. Karydis,¹ I. Loukopoulos,¹ G. Koffman,¹ R. Hilton,¹ J. Pattison,¹ C. Farmer,³ S. Shah,² E. Spigler,¹ N. Mamode,¹ N. Kessaris.¹
¹Guys Hospital, London, United Kingdom; ²Kings Hospital, London, United Kingdom; ³Kent & Canterbury Hospital, Kent, United Kingdom.
Introduction: Expanded criteria donors (ECDs) are those aged over 60 or 50-59 with 2 of: hypertension, death from cerebrovascular cause or terminal serum creatinine over…
2015 American Transplant Congress
Resolution of Glomerular Fibrin Thrombi in Deceased Donor Kidneys
R. Batra,¹ M. Smith,³ L. Thomas,² H. Khamash,² A. Moss,² J. Huskey,² A. Singer,¹ A. Mathur,¹ N. Katariya,¹ K. Reddy,¹ R. Heilman.²
¹Transplant Surgery, Mayo Clinic, Phoenix, AZ; ²Transplant Nephrology, Mayo Clinic, Phoenix, AZ; ³Pathology, Mayo Clinic, Phoenix, AZ.
BackgroundDeceased donor kidneys with Glomerular Fibrin Thrombi (GFT) are frequently discarded, but these kidneys may offer an opportunity to increase deceased donor organs. Our aim…
2015 American Transplant Congress
Outcome of Kidney Transplantation from Older Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens
K. Omoto,¹ D. Toki,¹ M. Okumi,¹ T. Shimizu,¹ H. Ishida,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.
OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantations from older living donors has not been studied yet. We reviewed graft outcomes…
2015 American Transplant Congress
Survival Outcomes of Kidney Transplant Recipients from Expanded Criteria Donors: A Systematic Review and Meta-Analysis
A.-H. Querard,^1,2,3 F. Gillaizeau,^1,3 Y. Foucher,^1,3 E. Dantan,³ D. Larmet,¹ M. Lorent,³ L.-M. Pouteau,¹ C. Combescure,⁴ M. Giral.^1,3,5
¹Institute for Transplantation, Urology and Nephrology, CHU Nantes, Inserm U1064, Nantes University, Nantes, France; ²Centre Hospitalier Départemental de Vendée, La Roche sur Yon, France; ³EA 4275 SPHERE-bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch, Nantes University, Nantes, France; ⁴CRC & Division of Clinical Epidemiology, Department of Health and Community Medicine, University of Geneva, Geneva, Switzerland; ⁵LabExTransplantex Nantes, Centre d'Investigation Clinique Biothérapie, Nantes, France.
Background: In 2002, UNOS proposed the use of Expanded Criteria Donors (ECD=brain dead donor > 60 years, or 50-59 years with two criteria: CVA as…
2015 American Transplant Congress
"In-House" Controlled Oxygenated Rewarming After Initial Static Cold Storage: First Clinical Application in Marginal Donor Livers
D. Hoyer,¹ Z. Mathé,¹ A. Gallinat,¹ A. Canbay,² J. Treckmann,¹ U. Rauen,³ A. Paul,¹ T. Minor.⁴
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; ⁴Surgical Research Division, University Hospital Bonn, Bonn, Germany.
IntroductionControlled oxygenated rewarming of cold stored livers by machine perfusion demonstrated a strong protective effect in preclinical studies. Here we report on the first clinical…