National Outcomes of Kidney Tranplantation from Diabetic Donors: A Mate-Kidney Analysis
1Renal Division, Univ. of Penn, Philadelphia, PA
2Dept of Surgery, Univ. of Penn, Philadelphia, PA
3Division of Gastroenterology, Univ. of Penn, Philadelphia, PA.
Meeting: 2015 American Transplant Congress
Abstract number: 44
Session Information
Session Name: Concurrent Session: Kidney Utilization/Center Issues
Session Type: Concurrent Session
Date: Sunday, May 3, 2015
Session Time: 2:15pm-3:45pm
Presentation Time: 2:51pm-3:03pm
Location: Room 121-AB
Utilization of diabetic donor kidneys has increased, though scarce patient and allograft survival data are available for recipients of these organs. Using United Network for Organ Sharing registry data, we performed a study of all US kidney recipients transplanted 3/11/1994-12/3/13. We used multivariable cox analyses to compare outcomes between pairs of recipients receiving a kidney from the same donor, stratified by diabetes status of both donor and recipient. Among pairs where one recipient was diabetic and the mate recipient was non-diabetic, 1,539 received diabetic donor kidneys; 21,459 received non-diabetic donor kidneys. In recipients of diabetic donor kidneys, non-diabetic recipients had lower rates of graft failure (adjusted HR 0.81, 95% CI 0.67-0.96, p = 0.02) and death (adjusted HR 0.65, 95% CI 0.52-0.82, p 0.001) compared to diabetic mate-kidney recipients. There was no difference in the rate of graft failure when diabetic recipients of non-diabetic donor kidneys were compared with non-diabetic recipients of diabetic donor kidneys. Diabetic donor kidneys are associated with increased risk of graft loss and death compared to non-diabetic donor kidneys, especially in diabetic recipients.
Predicting death | Predicting graft loss | |||||
HR | p value | 95%CI | HR | p value | 95%CI | |
NonDM donor | ||||||
-NonDM Recip | REF | REF | ||||
-DM Recip | 1.93 | <0.001 | 1.81-2.06 | 1.49 | <0.001 | 1.41-1.57 |
DM Donor | ||||||
-NonDM Recip | 0.65 | <0.001 | 0.52-0.82 | 0.81 | 0.02 | 0.67-0.96 |
-DM Recip | REF | REF | ||||
age | 1.93 | <0.001 | 1.70-2.19 | 0.99 | 0.91 | 0.91-1.09 |
male | 1.03 | 0.59 | 0.94-1.12 | 1.09 | 0.03 | 1.01-1.17 |
Black | 0.95 | 0.38 | 0.86-1.06 | 1.15 | 0.002 | 1.05-1.25 |
Pretxp dialysis | 1.05 | <0.001 | 1.03-1.07 | 1.05 | <0.001 | 1.03-1.06 |
Prior txp | 1.20 | 0.03 | 1.02-1.42 | – | ||
HCV+ | 1.09 | 0.42 | 0.88-1.34 | – | ||
PRA>30 | – | 1.21 | <0.001 | 1.09-1.34 | ||
No induction | – | 1.06 | 0.20 | 0.97-1.16 |
To cite this abstract in AMA style:
Cohen J, Reese P, Porrett P, Bloom R, Forde K, Sawinski D. National Outcomes of Kidney Tranplantation from Diabetic Donors: A Mate-Kidney Analysis [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/national-outcomes-of-kidney-tranplantation-from-diabetic-donors-a-mate-kidney-analysis/. Accessed October 3, 2024.« Back to 2015 American Transplant Congress