Articles tagged "Malignancy"

2022 American Transplant Congress
Increased Regulatory T-cells in Tumor Microenvironment is Associated with Hepatocellular Carcinoma Differentiation in Patients Undergoing Liver Transplantation
G. Orozco¹, R. Gedaly², L. Turcios², F. Marti²
¹Surgery, University of Kentucky, Lexington, KY, ²UKHC, Lexington, KY
*Purpose: Tumor-infiltrating lymphocytes are an essential component of the tumor microenvironment. The balance between cytotoxic effector T cells and immunosuppressive regulatory T cells is critical…
2022 American Transplant Congress
Establishing a New Hepatobiliary Surgery Program in a Level 1 Trauma Center Community Teaching Hospital (Our Open and Robotic Experience)
J. S. Han, S. A. Neubauer, C. E. Renner, C. M. Dunham, T. J. Chirichella
General Surgery, St. Elizabeth Youngstown Hospital, Youngstown, OH
*Purpose: To improve access to quality care, the surgical outcomes and influencing factors were investigated for a new hepatobiliary surgery program established by a transplant…
2022 American Transplant Congress
Is Repeat Resection for Recurrent Intrahepatic Cholangiocarcinoma Warranted? Outcomes of an International Multicenter Analysis
M. L. Holzner¹, V. Mazzaferro², M. Droz dit Busset², L. Aldrighetti³, F. Ratti³, K. Hasegawa⁴, J. Arita⁴, G. Sapisochin⁵, P. Abreu⁵, W. Schoening⁶, N. Nevermann⁶, M. Schmelzle⁶, J. Pratschke⁶, S. Florman¹, K. Halazun⁷, M. E. Schwartz¹, P. Tabrizian¹
¹Recanati/Miller Transplantation Institute, Mount Sinai, New York, NY, ²University of Milan, Milan, Italy, ³San Raffaele Hospital, Milan, Italy, ⁴University of Tokyo, Tokyo, Japan, ⁵University of Toronto, Toronto, ON, Canada, ⁶Charite University, Berlin, Germany, ⁷Weill Cornell Medical Center, New York, NY
*Purpose: Recurrence of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR) remains high and optimal therapy for recurrent ICC is challenging. Herein we assess the outcomes…
2022 American Transplant Congress
De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft
T. Khaja¹, L. Truong², G. Nassar¹
¹Nephrology, Houston Methodist Hospital, Houston, TX, ²Pathology, Houston Methodist Hospital, Houston, TX
*Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…
2022 American Transplant Congress
Transplant Combined with Neoadjuvant Therapy Improves Survival for Patients with Liver-Limited, Locally Advanced Intrahepatic Cholangiocarcinoma: A SEER Database Analysis
G. G. Panayotova¹, M. Javle², S. Pentakota¹, F. Paterno¹, A. Amin¹, L. Brown¹, S. Simonishvili¹, Y. Qin¹, T. Ayorinde¹, G. Prakash¹, C. Conrad³, J. V. Guarrera¹, K. E. Lunsford¹
¹Rutgers New Jersey Medical School, Newark, NJ, ²University of Texas, MD Anderson Cancer Center, Houston, TX, ³St. Elizabeth's Medical Center, Boston, MA
*Purpose: Preliminary single-center data suggest multimodal therapy may improve outcomes for patients with intrahepatic cholangiocarcinoma (iCCA) undergoing liver transplant (LT), particularly in the setting of…
2022 American Transplant Congress
Metastatic BK Virus-Associated Urothelial Carcinoma Originating in Renal Allograft
J. Torrealba¹, H. Jones¹, A. Bhakta², L. Jia¹, D. Wojciechowski²
¹Pathology, UT Southwestern, Dallas, TX, ²Internal Medicine, UT Southwestern, Dallas, TX
*Purpose: Cases of urinary tract carcinoma associated with BK virus have been reported in kidney transplant recipients; therefore, we postulate that BK virus may play…
2022 American Transplant Congress
Seroprevalence of HHV8 Among Donors and Recipients with HIV
P. H. Nambiar¹, T. Liang², J. D. Motter³, W. Werbel³, S. Mehta⁴, V. Kirchner⁵, M. Rana⁶, S. Florman⁷, J. Odim⁸, W. Miley⁹, N. Labo⁹, D. Whitby⁹, A. Massie¹⁰, D. Segev³, A. Tobian³, C. Durand²
¹Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, ²Medicine, Johns Hopkins University, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD, ⁴New York University Langone Transplant Institute, New York, NY, ⁵University of Minnesota, Minneapolis, MN, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Mount Sinai Medical Center, New York, NY, ⁸National Institute of Health, Bethesda, MD, ⁹National Cancer Institute, Frederick, MD, ¹⁰Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Kaposi sarcoma (KS) can develop post-transplant via recipient HHV8 reactivation or donor-acquired HHV8. In the general US population, HHV8 seroprevalence is low (1-5%), yet…
2022 American Transplant Congress
Cutaneous Angiosarcoma in Solid Organ Transplant Recipients – Novel Case & Review of the Literature
S. M. Elzein, R. R. Caplan
Houston Methodist Hospital, Houston, TX
*Purpose: Cutaneous angiosarcoma, a rare and extremely aggressive malignant neoplasm, has been described in fewer than twenty-five solid organ transplant recipients to date. Secondary, or…
2022 American Transplant Congress
Risk of Post-Transplant Lymphoproliferative Disease After Anti-Thymocyte Globulin in Childhood Solid-Organ Transplant Recipients
A. M. McKay¹, C. Teoh¹, J. Vasilevska-Ristovka², J. Browne², T. Banh², A. Dipchand¹, V. Ng¹, M. Solomon¹, U. Allen¹, Y. Avitzur¹, R. Parekh³
¹Transplant & Regenerative Medicine Centre, The Hospital for Sick Children, Toronto, ON, Canada, ²Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, Department of Medicine, Women’s College Hospital and University Health Network, Toronto, ON, Canada
*Purpose: Determine if the use of anti-thymocyte globulin (ATG) in pediatric solid organ transplant recipients was associated with an increased risk of post-transplant lymphoproliferative disorder…
2022 American Transplant Congress
Risk of Tumor Recurrence, Functional Decline, and Metastatic Disease of Renal Transplant in Recipients with Hereditary Kidney Cancer: A Case Series
M. Antony, A. Chaurasia, N. Gopal, Z. Kozel, M. Linehan, M. Ball
Urologic Oncology Branch, National Cancer Institute, Bethesda, MD
*Purpose: Von Hippel-Lindau disease is a hereditary cancer syndrome characterized by bilateral, multifocal renal tumors and cysts. Advancements in nephron-sparing surgeries have improved functional and…