Articles tagged "Malignancy"

2019 American Transplant Congress
Characteristics And Outcomes Of Early Onset Cancers After Kidney Transplantation
W. Lim¹, E. Au², A. Krishnan¹, G. Wong²
¹Sir Charles Gairdner Hospital, Perth, Australia, ²University of Sydney & Westmead Hospital, Sydney, Australia
*Purpose: Incident cancers developing after kidney transplantation are associated with significant morbidity and mortality and therefore age-appropriate cancer screening is recommended to identify asymptomatic cancers…
2019 American Transplant Congress
Whole Body CT Imaging in Deceased Donor Screening
J. W. Mensink¹, R. A. Pol.², W. N. Nijboer¹, J. de Jonge³, K. M. Ooms - de Vries⁴, M. F. van der Jagt⁵, M. C. van de Poll⁶, I. P. Alwayn¹, A. E. Braat¹
¹Department of Surgery; Division of Transplantation, Leiden University Medical Center, Leiden, Netherlands, ²Department of Surgery; Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands, ³Department of Surgery; Division of Transplantation, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Dutch Transplant Foundation, Leiden, Netherlands, ⁵Department of Surgery; Division of Transplantation, University Medical Center St. Radboud, Nijmegen, Netherlands, ⁶Department of Surgery and Department of Intensive Care, Maastricht University Medical Center, Maastricht, Netherlands
*Purpose: Using older (extended criteria) donors to increase the donor pool increases the risk of malignancies in the donor. Our aim was to analyze the…
2019 American Transplant Congress
Genome-Wide Profiling of BK Polyomavirus Integration in Urothelial Carcinoma of Kidney Transplant Recipients Reveals a Potential Microhomology or Nonhomologous End Joining Mediated Integration Mechanism
Y. Jin¹, Y. Zhou¹, W. Deng¹, R. Lee², Y. Liu¹, M. Blute³, R. Liu¹, N. Elias⁴, F. Fu¹, B. Guan¹, J. Geng¹, J. Ma⁵, J. Zhou⁵, N. Liu⁵, C. Wu⁶, Y. Miao¹
¹Nanfang Hospital, Southern Medical University, Guangdzhou, China, ²Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Departments of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Mygenostics Co., Beijing, China, ⁶Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Chronic BK polyomavirus (BKV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Besides, a positive correlation…
2019 American Transplant Congress
Risk Factors for 1-5 Year De Novo Cancers after Kidney Transplant (KTx) with First-Year Immunosuppression (IS) Data: An Analysis of the Choosing Immune Suppression by Efficacy and Morbidity (CISTEM) Study
V. Dharnidharka¹, D. Axelrod², Z. Zhang³, M. Schnitzler³, K. Lentine³, B. Kasiske⁴
¹Washington Univ, St. Louis, MO, ²Univ of Iowa, Iowa City, IA, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN
*Purpose: From our CISTEM study of linked national registries, we published data on risk factors for within-3-years post-KTx non-melanoma skin cancer (NMSC) and viral-driven cancers…
2019 American Transplant Congress
Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis
A. Chewcharat¹, C. Thongprayoon², B. Boonpheng³, A. Torres-Ortiz⁴, M. A Mao², N. J Khoury⁵, W. Cheungpasitporn⁴
¹Harvard T.H. Chan, Boston, MA, ²Mayo Clinic, Rochester, MN, ³East Tennessee State University, Johnson City, TN, ⁴University of Mississippi Medical Center, Jackson, MS, ⁵Henry Ford Hospital, Detroit, MI
*Purpose: The incidence and mortality of renal cell carcinoma (RCC) after kidney transplantation (KTx) remain unclear. This study's aims were 1) to investigate the pooled…
2019 American Transplant Congress
Lower Incidence of Posttransplant Malignancies under Vitamin D (Calcidiol) Treatment in Kidney Transplantation
I. Revuelta¹, V. Tubita², J. Ugalde¹, D. Cucchiari¹, F. Oppenheimer¹, F. Diekmann¹, J. Campistol¹, J. Torregrosa¹
¹Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain
*Purpose: An increasing body of evidence has emerged on the role of 1α,25-dihydroxyvitamin D3[1,25(OH) 2 D] in cell differentiation, which seems to have regulation properties…
2019 American Transplant Congress
Kidney Transplant Outcomes in Patients with ESRD Due to Myeloma
A. Riaz, A. Khalil, M. S. Yaqub, T. Taber, O. Adebiyi, A. Sharfuddin
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Recent literature has suggested that certain patients with multiple myeloma can successfully undergo renal transplantation after stem transplantation with consideration for maintenance therapy. Outcomes…
2019 American Transplant Congress
Development and Characterization of Human-Derived Xenograft Model for Hepatocellular Carcinoma
M. Nazzal¹, R. Steele², R. Ray³, N. Phillips², J. Long⁴, R. Ray²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pathology, Saint Louis University, Saint Louis, MO, ³Internal Medicine, Saint Louis University, Saint Louis, MO, ⁴Comparative Medicine, Saint Louis University, Saint Louis, MO
*Purpose: Hepatocellular carcinoma (HCC) is rising in the USA and treatment options are limited. There is no convenient animal model for HCC to study novel…
2019 American Transplant Congress
Long Term Follow-Up of the Use of Checkpoint Inhibitors in Kidney Transplant Recipients
K. Venkatachalam, R. Delos Santos, T. Alhamad
Transplant nephrology, Washington University, St. Louis, MO
*Purpose: To report the long term impact of check point inhibitors in patient and allograft survival among kidney transplant recipients.*Methods: We report follow up of…
2018 American Transplant Congress
Outcomes Analysis of Liver Transplantation Combined with Neoadjuvant Therapy in Patients with Unresectable Locally-Advanced Cholangiocarcinoma
M. Wong,¹ J. Kim,¹ C. Eriksen,¹ T. Pearson,¹ J. Robbins,² B. George,³ M. Zimmerman,¹ J. Hong.¹
¹Div. of Transplant Surgery, Medical College of Wisconsin and Froedtert Hospital (MCW & FH), Milwaukee, WI; ²Dept. of Radiation Oncology, MCW & FH, Milwaukee, WI; ³Div. of Hematology/Oncology, MCW & FH, Milwaukee, WI.
Objective: Liver transplantation (LT) combined with neoadjuvant chemoradiation (NCR) in well-selected patients with unresectable cholangiocarcinoma (CCA) achieves excellent long-term recurrence-free survival. Current criteria for NCR-LT…

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