Articles tagged "Machine preservation"

2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹
¹Toronto General Hospital, Toronto, ON, Canada, ²University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…
2019 American Transplant Congress
Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion
C. J. Stewart¹, M. T. Buchko², X. Wang¹, G. Brandacher³, A. Ladak⁴, D. H. Freed², J. Nagendran²
¹Surgery, University of Alberta, Edmonton, AB, Canada, ²Cardiac Surgery, University of Alberta, Edmonton, AB, Canada, ³Plastic and Reconstruction Surgery, Johns Hopkins University, Baltimore, MD, ⁴Plastic Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Our objective is to demonstrate that Ex-Vivo Extremity Perfusion (EVEP) of a Vascularized Composite Allograft (VCA) is as effective, or superior, to standard cold…
2019 American Transplant Congress
Near-Infrared Fluorescence Imaging with ZW800-1 Dye to Assess Donor Kidneys While on Ex-Vivo Normothermic Machine Perfusion
A. S. Arykbaeva¹, K. M. Rozenberg², M. L. Lo Faro², J. Hunter², J. B. Doppenberg¹, A. R. Valentijn³, A. G. Terwisscha van Scheltinga³, H. Putter⁴, I. P. Alwayn¹, J. V. Frangioni⁵, J. Burggraaf⁶, A. L. Vahrmeijer¹, R. J. Ploeg², V. A. Huurman¹
¹Department of Surgery, Leiden University Medical Center, Leiden, Netherlands, ²Nuffield Department of Surgical Sciences, Oxford, United Kingdom, ³Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands, ⁵Curadel, LCC, Marlborough, MA, ⁶Centre for Human Drug Research, Leiden, Netherlands
*Purpose: At present, more older and higher risk donor kidneys are accepted resulting in increased uncertainty about quality. This may result in unjustified discard of…
2019 American Transplant Congress
Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion
D. Detelich¹, R. de Vries¹, C. Carroll¹, M. Stein², K. Uygun¹, H. Yeh¹, J. Markmann¹
¹Massachusetts General Hospital, Boston, MA, ²Kamada, Rehovot, Israel
*Purpose: Normothermic machine perfusion is an emerging preservation method in liver transplantation with vast potential as a platform for ex-vivo graft reconditioning. Alpha-1 Antitrypsin (AAT)…
2019 American Transplant Congress
Ex-vivo Xenoperfusion Of Wild Type And Galtko.hcd55 Pig Livers With Human Whole Blood
D. Detelich, C. Rickert, C. Eymard, C. Carroll, S. Kimura, H. Yeh, J. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: Pig-to-human liver xenotransplantation is not currently feasible due to rapid and profound thrombocytopenia, coagulopathy and hyperacute rejection. Successful development of genetically modified swine to…
2019 American Transplant Congress
Novel Molecular Mechanisms Associated with Normothermic Ex-Vivo Kidney Perfusion
C. McEvoy¹, T. Tokar², S. Reid³, P. Urbanellis³, M. Hamar¹, M. Kaths¹, I. Jurisica², L. Robinson⁴, M. Selzner¹, A. Konvalinka¹
¹MOT Programme, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Sick Kids Research Institute, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is associated with significantly improved graft function following transplantation in comparison to static cold storage (SCS), however the molecular…
2019 American Transplant Congress
Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion
A. Weissenbacher¹, C. D. Ceresa², D. Voyce³, J. Hunter², R. Ploeg², C. C. Coussios⁴, P. Friend²
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³OrganOx Limited, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
*Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
2019 American Transplant Congress
Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model
I. Linares-Cervantes, D. Kollmann, T. Goto, J. Echeverri, M. Kaths, M. Hamar, P. Urbanellis, L. Mazilescu, R. Rosales, C. Bruguera, F. Oquendo, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…
2019 American Transplant Congress
Assessing Discarded Human Liver Quality with Normothermic Ex-Vivo Liver Perfusion
F. Zhou, M. Xu, S. Garcia-Aroz, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: Normothermic Ex-vivo Liver Perfusion (NELP) of livers shows promising results in overcoming injuries that occur in deceased donor liver transplantation. The effect of NELP…
2019 American Transplant Congress
Dynamic Characterization of Cells in the Perfusate from Cold Ischemic Liver Grafts
R. J. de Vries, C. Pendexter, S. E. Cronin, B. Marques, J. F. Markmann, S. L. Stott, H. Yeh, M. Toner, K. Uygun, S. N. Tessier
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Injury during preservation is a complex process that affects graft function. A deeper understanding and better prediction of liver viability are demanded to improve…

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