2019 American Transplant Congress
Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion
*Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…2019 American Transplant Congress
Elevated Podocyte-specific Urinary Extracellular Vesicles In Patients With Fsgs Recurrence After Kidney Transplantation
University of California Irvine, Orange, CA
*Purpose: Kidney graft failure is a major concern in patients with kidney transplantation. Patients who suffered graft failure are at a higher risk for mortality…2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…2019 American Transplant Congress
Defatting Steatotic Rat Livers during Ex Situ Normothermic Perfusion Improves Lactate Clearance and Bile Quality
*Purpose: Donor livers with moderate-to-severe steatosis are not generally used for transplantation because of poor post-transplant function. Ex situ normothermic machine perfusion (ENMP) provides an…2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial Outcomes: Proteomic Analysis of Perfusates from Livers Undergoing Normothermic Machine Liver Perfusion Reveals Biomarkers Predictive of Graft Viability and Post-Transplant Complications
*Purpose: The VITTAL clinical trial demonstrated that post-ischaemic normothermic machine perfusion(NMP) can increase utilisation of livers from the marginal pool of extended criteria donors (ECD).…2019 American Transplant Congress
Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance
Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…2019 American Transplant Congress
Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…2019 American Transplant Congress
A Novel Multi-Thermic, Antiseptic, and Anthropomorphic System for Ex-Vivo Face Perfusion
*Purpose: Facial disfigurement is profoundly disabling, and great relief follows resolution by facial transplantation, now a technical reality at multiple centers worldwide. However, distance between…2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
1Toronto General Hospital, Toronto, ON, Canada, 2University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…2019 American Transplant Congress
Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion
*Purpose: Our objective is to demonstrate that Ex-Vivo Extremity Perfusion (EVEP) of a Vascularized Composite Allograft (VCA) is as effective, or superior, to standard cold…
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