ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Machine preservation"

  • 2022 American Transplant Congress

    Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts

    K. Andrijauskaite, R. J. Veraza, R. P. Lopez, E. C. Cisneros, I. J. Jessop, M. D. Watt, L. Bunegin

    Vascular Perfusion Solutions, Inc, San Antonio, TX

    *Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…
  • 2022 American Transplant Congress

    Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft

    D. Yoeli, Y. Wang, B. Li, J. Huang, S. Jain, Z. Wang, N. Nakra, N. Limon De La Rosa, K. Rampalski, A. Su, D. Mathes, K. Washington, E. Farkash, A. Jani, C. Huang

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…
  • 2022 American Transplant Congress

    Enhanced Delivery of Nanomedicine to Human Kidney During Ex Vivo Perfusion

    C. Albert1, L. Bracaglia1, A. Koide2, J. R. DiRito1, T. Lysyy1, E. Christopher1, J. Grundler1, J. T. Langford1, D. Haakinson1, J. S. Pober1, W. M. Saltzman1, S. Koide2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY

    *Purpose: An efficient delivery of therapeutic agents to graft endothelial cells (ECs) prior to transplantation could render organs more resistant to injury, improving clinical outcomes…
  • 2022 American Transplant Congress

    Normothermic Ex Vivo Perfusion of Discarded Human Pancreases: A Feasibility Study to Expand the Pancreas Donor Pool

    C. Parmentier, S. Ray, L. Mazilescu, M. Kawamura, Y. Noguchi, T. Goto, B. Arulratnam, S. Ganesh, M. Selzner, T. Reichman

    UHN - Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Vivo Perfusion (NEVPP) model has been used in the clinical setting for Lung, heart, liver, and kidney. However, a system for human…
  • 2022 American Transplant Congress

    Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure

    R. X. Liu1, N. Koyawala2, H. T. Philbrook2, I. Hall3, P. Reese4, S. Mohan5, M. Doshi6, C. Parikh1

    1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, 3University of Utah School of Medicine, Salt Lake City, UT, 4University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 5University of Columbia Vagelos College of Physicians & Surgeons, New York, NY, 6University of Michigan, Ann Arbor, MI

    *Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…
  • 2022 American Transplant Congress

    Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion

    T. Goto, Y. Noguchi, S. Ganesh, B. Arulratnam, M. Kawamura, C. Parmentier, S. Ray, T. Reichman, N. Selzner, M. Selzner

    Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada

    *Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…
  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
  • 2022 American Transplant Congress

    Comparison of Vasodilators in Dual Vessel Normothermic Ex Vivo Liver Machine Perfusion of Rat Liver Grafts

    J. M. Gassner, F. Strobl, J. Michelotto, K. Kristina, V. Muth, M. Zimmer, L. Gilles, S. Moosburner, J. Pratschke, I. Sauer, N. Raschzok

    Department of Surgery, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    *Purpose: Small animal models of normothermic ex vivo liver machine perfusion (NEVLP) comparable to clinically used protocols are vital to perform translational studies on organ…
  • 2022 American Transplant Congress

    Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model

    N. Abraham1, M. Zhang1, P. Cray2, R. Neill1, G. Cywinska1, J. Migaly1, R. Kahan1, A. Pontula1, J. Penaflor1, Q. Gao1, K. P. Samy1, J. J. Pollara2, V. Novokhatny3, M. G. Hartwig1, A. S. Barbas1

    1Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, 2Duke Division of Surgical Sciences, Pollara lab, Durham, NC, 3Bioscience Industrial Group, Grifols R&D, Durham, NC

    *Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
  • 2021 American Transplant Congress

    Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA

    M. Goutard1, R. J. de Vries1, A. G. Lellouch1, E. Lupon1, C. Pendexter1, S. N. Tessier1, M. A. Randolph1, L. Lantieri2, C. L. Cetrulo1, K. Uygun1

    1Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, 2Hôpital Européen Georges Pompidou, Paris, France

    *Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
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