2022 American Transplant Congress
Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts
Vascular Perfusion Solutions, Inc, San Antonio, TX
*Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…2022 American Transplant Congress
Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…2022 American Transplant Congress
Enhanced Delivery of Nanomedicine to Human Kidney During Ex Vivo Perfusion
*Purpose: An efficient delivery of therapeutic agents to graft endothelial cells (ECs) prior to transplantation could render organs more resistant to injury, improving clinical outcomes…2022 American Transplant Congress
Normothermic Ex Vivo Perfusion of Discarded Human Pancreases: A Feasibility Study to Expand the Pancreas Donor Pool
UHN - Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Perfusion (NEVPP) model has been used in the clinical setting for Lung, heart, liver, and kidney. However, a system for human…2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…2022 American Transplant Congress
Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion
*Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…2022 American Transplant Congress
Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation
*Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…2022 American Transplant Congress
Comparison of Vasodilators in Dual Vessel Normothermic Ex Vivo Liver Machine Perfusion of Rat Liver Grafts
*Purpose: Small animal models of normothermic ex vivo liver machine perfusion (NEVLP) comparable to clinically used protocols are vital to perform translational studies on organ…2022 American Transplant Congress
Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model
*Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
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