Articles tagged "Machine preservation"

2022 American Transplant Congress
Characterisation of Kidney-Specific Extracellular Vesicles During Isolated Organ Normothermic Machine Perfusion
J. Ashcroft¹, T. L. Williams², T. R. Elliott¹, A. Marton¹, S. A. Hosgood¹, M. L. Nicholson¹, V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
*Purpose: Introduction: Normothermic machine perfusion (NMP) can evaluate and recondition deceased-donor kidneys but accurate biomarkers are needed to assess organ quality and to predict post-transplant…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Pulsatile Kidney Perfusion Improves Survival and Graft Function in High Acuity Combined Liver Kidney Transplant (CLKT) Recipients
T. Liu¹, G. Panayotova², F. Paterno³, A. Amin², L. Brown⁴, J. Guarrera⁵, K. Lunsford⁶
¹Surgery, Rutgers New Jersey Medical School, Newark, NJ, ²Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, Newark, NJ, ³Rutgers State University of New Jersey, Montclair, NJ, ⁴Rutgers New Jersey Medical School, Morris Plains, NJ, ⁵Surgery/ Transplant, Rutgers New Jersey Medical School, Newark, NJ, ⁶Rutgers New Jersey Medical School, Newark, NJ
*Purpose: Due to underlying renal dysfunction, CLKT recipients tend to have higher medical acuity at baseline resulting in a higher likelihood of post-operative complications and…
2022 American Transplant Congress
Lipid Metabolism Profile of Human Kidneys During Ex Vivo Normothermic Perfusion
J. Yu, I. Palma, S. Adams, J. Sageshima, P. Than, R. Perez
UC Davis Medical Center, Sacramento, CA
*Purpose: The kidney is a highly metabolic organ and lipids are an important energy source. In this study, we examined the lipid profiles of discarded…
2022 American Transplant Congress
A Multicenter Randomized Controlled Trial To Compare The Efficacy Of Ex-vivo Machine Perfusion With Static Cold Storage In Human Liver Transplantation: The University Of Maryland Experience
J. Avruch¹, N. Goussous², S. Malik¹, M. Pinedo¹, R. Meier¹, C. Bhati¹, D. Maluf¹, R. Barth³, J. Alvarez-Casas¹
¹Transplant Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Transplant Surgery, University of California Davis Health, Davis, CA, ³University of Chicago, Chicago, IL
*Purpose: There is accumulating clinical evidence of the benefit of normothermic ex-vivo machine perfusion (NMP) compared with traditional static cold storage of liver allografts prior…
2022 American Transplant Congress
Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia
V. Boominathan¹, M. Willman¹, N. Battula², A. Zarrinpar¹, S. Duarte¹
¹University of Florida, Gainesville, FL, ²University of Oklahoma, Oklahoma City, OK
*Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…
2022 American Transplant Congress
Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study
L. Lo Faro¹, A. Thorne², H. Huang³, P. Charles³, M. Kaisar¹, S. Davis³, F. Dengu¹, S. Shaheed¹, J. Mulvey¹, R. Fischer³, D. Nasralla⁴, B. Kessler³, H. Leuvenink², P. Friend¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Center Groningen, Groningen, Netherlands, ³Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
2022 American Transplant Congress
Final Flow and Resistance During Cold Pulsatile Perfusion Preservation Do Have Value in Prediction of Deceased Donor Graft Survival After Adjusting for KDPI
D. S. Keith, E. Lessmann
Kidney Transplant, Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine whether cold pulsatile perfusion preservation (CPPP) parameters of flow and resistance provide additional data regarding deceased donor kidney graft survival after adjusting…
2022 American Transplant Congress
Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model
L. Plumblee¹, K. Patel², L. Langerude³, Z. Tu³, D. Nord⁴, T. Beduschi³, S. Nadig⁵, C. Atkinson⁶
¹MUSC College of Medicine, Gainesville, FL, ²University of Virgina, Charlottesville, VA, ³University of Florida, Gaineville, FL, ⁴Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, ⁵Northwestern University, Charleston, SC, ⁶Pulmonary Medicine, University of Florida, Gainesville, FL
*Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
2022 American Transplant Congress
Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver
C. S. Hwang¹, C. Shi², M. Patel¹, J. Shah¹, L. DeGregorio¹, S. Hanish¹, Y. Kadakia³, U. Chaudhary³, E. Okoro², S. Cheruku², P. Lahsaei², P. Vagefi¹, M. MacConmara⁴
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ²Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴TransMedics, Andover, MA
*Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…