Articles tagged "Machine preservation"

2016 American Transplant Congress
Normothermic Perfusion of Livers Donated After Circulatory Death: A New Clinically Relevant Experimental Model.
Y. Cao,¹ H. Chew,^1,2 K. Fernandez,¹ L. Gao,¹ J. Villanueva,¹ M. Hicks,¹ P. Macdonald,^1,2 K. Dhital,^1,2 H. Pleass.³
¹Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; ²Cardiac Transplant Unit, St. Vincent's Hospital, Sydney, NSW, Australia; ³The Department of Surgery, Westmead Hospital, Sydney, NSW, Australia.
Aim. Transplantation using livers donation after circulatory death (DCD) is associated with worse outcomes compared to using donation after brain death (DBD). Considerable research resources…
2016 American Transplant Congress
Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.
M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.
Cleveland Clinic, Cleveland, OH.
Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
2016 American Transplant Congress
Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).
B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…
2016 American Transplant Congress
Predictive Model of Delayed Graft Function in Machine Perfused Kidney Transplantation: Model Validation Using Decision Curve Analysis.
K. Ravindra,¹ S. Sanoff,¹ D. Vikraman,¹ U. Patel,¹ M. Ellis,¹ E. Squires,² D. Sudan,¹ W. Irish.¹
¹Surgery, Duke University, Durham, NC; ²Half Moon Bay, Raleigh.
Introduction: Predictive model for delayed graft function (DGF) was developed (Am J Transpl 2010; 10: 2279–86)excluding organs that were machine perfused (MP). Currently, approximately 50%…
2016 American Transplant Congress
The Influence of Static versus Machine Dynamic Perfusion Kidney Graft Preservation on Delayed Graft Function Incidence: A Prospective, Randomized Study.
H. Marinho Neto, V. Aires, J. Offerni, W. Luconi, P. Luconi, S. Braga, I. Noronha, R. Barsante, J. Moreira, A. Savina, L. Kuschnaroff, F. Lemos, A. Cuvello, P. Chocair, L. Moura, A. Silva Filho, I. Charpiot, M. Abbud Filho, M. Cunha, P. Malafonte, D. Demetrio, L. Miorin, A. Duboc Filho, A. Claudini, W. Aguiar, H. Tedesco, J. Medina Pestana.
Organ Procurement Organization, Kidney Hospital, São Paulo, Brazil.
Introduction: The incidence of delayed graft function (DGF) in Brazilians deceased kidney donor receptors is high; this is attributed to poor hemodynamic conditions on potential…
2016 American Transplant Congress
Hypothermic Machine Perfusion Ameliorates Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells Through Upregulating Expression of Krüppel-Like Factors 2.
Z. Zhong,¹ D. Ko,² Y. Wang,¹ Q. Ye.¹
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan, Hubei, China; ²Massachusetts General Hospital, Department of Urology, Harvard Medical School, Boston, MA.
Protective mechanisms of hypothermic machine perfusion (MP) remain largely unknown. Vascular branches of the renal arteries of 6 kidneys in 320 donors were unexpectedly injured…
2016 American Transplant Congress
Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.
B. Bruinsma,¹ J. Avruch,² G. Sridharan,¹ P. Weeder,¹ N. Karimian,¹ J. Markmann,² K. Uygun,¹ H. Yeh.²
¹Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; ²Transplant Center, Massachusetts General Hospital, Boston, MA.
Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…
2016 American Transplant Congress
Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.
Q. Liu, A. Nassar, G. Iuppa, B. Soliman, L. Buccini, M. Blum, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland, OH.
One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…
2016 American Transplant Congress
Adding Anti-Inflammatory Agents During Normothermic Ex-Vivo Liver Perfusion Improves the Preservation of Pig Liver Grafts Before Transplantation.
N. Goldaracena, E. Juan, K. Moritz, V. Spetzler, A. Barbas, D. Grant, M. Selzner.
Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada.
Introduction: Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemic injury. We investigated if protective effects of NEVLP can be further…
2016 American Transplant Congress
Modified Normothermic Extracorporeal Liver Perfusion for Discarded Human Livers.
B. Banan,¹ R. Watson,² M. Xu,¹ Y. Lin,¹ W. Chapman.¹
¹Surgery, Washington University School of Medicine, St Louis; ²Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison.
Introduction: Donor organ shortages have led to increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic ex-vivo liver perfusion…