2016 American Transplant Congress
Adding Anti-Inflammatory Agents During Normothermic Ex-Vivo Liver Perfusion Improves the Preservation of Pig Liver Grafts Before Transplantation.
Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada.
Introduction: Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemic injury. We investigated if protective effects of NEVLP can be further…2016 American Transplant Congress
Modified Normothermic Extracorporeal Liver Perfusion for Discarded Human Livers.
Introduction: Donor organ shortages have led to increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic ex-vivo liver perfusion…2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) of Liver Allografts with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Increases β-Oxidation of Fatty Acids and Decreases Lipid Peroxidation (LP).
University of Pittsburgh, Pittsburgh.
Introduction: There is limited information about the lipid metabolic profile during liver allograft preservation. LP remains a major component of ischemia-reperfusion injuries (IRIs). The aim…2016 American Transplant Congress
Controlled Oxygenated Rewarming and Subnormothermic Machine Perfusion of Steatotic Livers: First Clinical Results.
IntroductionControlled oxygenated rewarming (COR) of cold stored livers by machine perfusion demonstrated convincing results in the first clinical pilot series (1). Here we report on…2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Solution for Ex Vivo Preservation in Vascularized Composite Allotransplantation (VCA).
University of Pittsburgh, Pittsburgh.
Background: Improved preservation techniques could reduce ischemia-reperfusion injuries (IRI) and allow better matching and allocation of VCA grafts across wider distances. A novel SNMP system…2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…2016 American Transplant Congress
Extreme Hyperoxia During Pre-Implant Normothermic Liver Perfusion (PINLiP) Is Associated with Post-Reperfusion Syndrome and Vasoplegia.
Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom.
In response to the increasing number of DCD and marginal DBD donor livers, we started a programme of pre-implant normothermic perfusion (PINLiP) to enable functional…2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) Leads to Increased Bile Production and Secretion of Hydrophilic Bile Acids After Liver Transplantation When Compared to Cold Storage (CS).
University of Pittsburgh, Pittsburgh.
Background: Bile production during machine perfusion and after transplantation has been used as marker of liver allograft viability and function. This study aimed to assess…2016 American Transplant Congress
Alterations in Central Carbohydrate Metabolism in Porcine Liver Allografts Preserved with a Subnormothermic Machine Perfusion (SNMP) System.
University of Pittsburgh, Pittsburgh.
Introduction: Combination of reduced temperature and oxygenation via machine perfusion during liver allograft preservation has the potential to induce profound effects on hepatocyte bioenergetics and…2016 American Transplant Congress
Machine Perfusion (MP) at 21[deg]C Simulates Hibernation Metabolic Pathways in a Non-Hibernator Mammal.
University of Pittsburgh, Pittsburgh.
Background: Hibernation is a complex and multi stage process that leads to unique metabolic changes over an extended period of time. Regulatory genes and transcription…
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