2017 American Transplant Congress
Early Results of the UK REVIVE Trial for Ex-Vivo Liver Warm Blood Perfusion of DCD and DBD Livers Using the Portable Organ Care System (OCS™) Liver Technology.
Hepatobiliary and Transplant Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Purpose:TheOCS Liver REVIVE Trial is a single-arm prospective trial to evaluate the safety and performance of OCS™ Liver system to preserve and assess DCD and…2017 American Transplant Congress
Outcomes from a Multinational Randomised Controlled Trial Comparing Normothermic Machine Perfusion with Static Cold Storage in Human Liver Transplantation.
Introduction:By perfusing a liver with oxygenated blood, medications and nutrients at 37oC, normothermic machine perfusion (NMP) may improve outcomes after liver transplantation when compared with…2017 American Transplant Congress
Steatotic Human Livers Show Inferior Function Compared to Non-Steatotic Livers During Ex-Situ Viability Assessment by Oxygenated Machine Perfusion.
Fatty livers are frequently declined for transplantation due to high risk of primary non-function. Ex-situ oxygenated machine perfusion (MP) is superior to static cold storage…2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…2017 American Transplant Congress
The Use of an Haemoglobin Based Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.
Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts in an environment that mimics physiological conditions and therefore enables…2017 American Transplant Congress
The Delivery of Stem Cell Therapy to Extended Criteria Donor Human Livers Using Normothermic Machine Perfusion.
Normothermic machine perfusion of the liver (NMP-L) has been used for organ preservation and viability testing of donor livers. Although previously proposed, delivery of cellular…2017 American Transplant Congress
Development of an Automatic Regulated Normothermic Kidney Preservation Device for Long-Term Organ Perfusion.
BackgroundNormothermic kidney perfusion for a period of 24 hours or longer would offer significant clinical advantages. It would enable clinicians to investigate the condition of…2017 American Transplant Congress
Human Organs Allocated for Research – Maximising Use of a Precious Resource Using a New Ex Vivo Model of Reperfusion Injury.
Imperial College, London, United Kingdom
Purpose: A greater interest in machine perfusion strategies for all solid organs has led to a substantial increase in the allocation and utilisation of human…2017 American Transplant Congress
Impact of STEEN vs Gelofusine as Perfusate During Normothermic Ex Vivo liver Perfusion on Outcome of Pig Liver Transplantation.
Multiorgan Transplant Program, Toronto General Hospital, Toronto, ON, Canada
European and North American clinical trials have used two different perfusate solutions for normothermic ex vivo liver perfusion (NEVLP): Gelofusine (bovine derived gelatin-based solution) and…2017 American Transplant Congress
Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.
Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
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