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Articles tagged "Machine preservation"

  • 2017 American Transplant Congress

    First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.

    Q. Liu, B. Soliman, G. Iuppa, A. Nassar, A. Hassan, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland

    NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…
  • 2017 American Transplant Congress

    Cost-Effectiveness of Renal Machine Perfusion Use After Long Cold Ischemia Time.

    A. Matos,1 D. Malheiro,3 S. Morgado,1 L. Requi[acirc]o-Moura,1 M. Souza-Durão,1,2 E. Tonato,1 M. Nogueira,1 M. Borrelli,1 A. Pacheco-Silva.1,2

    1Renal Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil; 3Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil

    High cold ischemia time (CIT) and inadequate care of donors in Brazil lead to a high incidence of delayed graft function (DGF), 60%-70%, and as…
  • 2017 American Transplant Congress

    36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.

    J. Magliocca,1 J. Markmann,2 M. Abouljoud,3 M. Ghobrial,4 A. Demetris.5

    1Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; 2Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; 3Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 4Surgery - General, Houston Methodist Hospital, Houston, TX; 5Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
  • 2017 American Transplant Congress

    Results of the Initial Phase of the Portable Organ Care System (OCS™) Liver PROTECT Pivotal Trial.

    J. Markmann,1 M. Ghobrial,3 J. Magliocca,4 A. Demetris,5 M. Abouljoud.2

    1Department of Surgery-Division of Transplantation, Massachusetts General Hospital, Boston, MA; 2Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 3Sherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, TX; 4Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; 5Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    PurposeThe OCS Liver PROTECT Trial is a prospective, international, randomized controlled trial to evaluate the impact of using portable ex-vivo warm, oxygenated blood perfusion using…
  • 2017 American Transplant Congress

    Early Results of the UK REVIVE Trial for Ex-Vivo Liver Warm Blood Perfusion of DCD and DBD Livers Using the Portable Organ Care System (OCS™) Liver Technology.

    D. Vijayanand, F. Zahreldeen, J. Kingston, S. Farid, T. Mdlongwa, A. Ramsden, S. Willis, C. Moriarty, M. Attia.

    Hepatobiliary and Transplant Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Purpose:TheOCS Liver REVIVE Trial is a single-arm prospective trial to evaluate the safety and performance of OCS™ Liver system to preserve and assess DCD and…
  • 2017 American Transplant Congress

    Outcomes from a Multinational Randomised Controlled Trial Comparing Normothermic Machine Perfusion with Static Cold Storage in Human Liver Transplantation.

    D. Nasralla,1 Consortium for Organ Preservation in Europe Liver Research Group,1 R. Ploeg,1 C. Coussios,2 P. Friend.1

    1Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; 2Department of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

    Introduction:By perfusing a liver with oxygenated blood, medications and nutrients at 37oC, normothermic machine perfusion (NMP) may improve outcomes after liver transplantation when compared with…
  • 2017 American Transplant Congress

    Steatotic Human Livers Show Inferior Function Compared to Non-Steatotic Livers During Ex-Situ Viability Assessment by Oxygenated Machine Perfusion.

    N. Karimian,1 V. Huang,1 F. Fontan,1 M. Aburawi,1 S. Geerts,1 S. Mert,1 I. Beijert,2 R. Porte,2 M. Yarmush,1 K. Uygun,1 J. Markmann,1 H. Yeh.1

    1Division of Transplantation, Massachusetts General Hospital, Boston; 2Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands

    Fatty livers are frequently declined for transplantation due to high risk of primary non-function. Ex-situ oxygenated machine perfusion (MP) is superior to static cold storage…
  • 2017 American Transplant Congress

    Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.

    M. Bral,1 N. Aboelnazar,2 B. Gala-Lopez,2 S. Hatami,2 D. Freed,1 A. Shapiro.1

    1Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada

    One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
  • 2017 American Transplant Congress

    The Use of an Haemoglobin Based Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.

    Y. Boteon,1 R. Laing,1 R. Bogal,1 D. Neil,2 A. Smith,2 B. Stephenson,2 A. Schlegel,2 S. Hübscher,2 D. Mirza,2 S. Afford,1 H. Mergental.2

    1Center of Liver Research, University of Birmingham, Birmingham, United Kingdom; 2Liver Unit Queen Elizabeth Hospital, University Hospital Birmingham, Birmingham, United Kingdom

    Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts in an environment that mimics physiological conditions and therefore enables…
  • 2017 American Transplant Congress

    The Delivery of Stem Cell Therapy to Extended Criteria Donor Human Livers Using Normothermic Machine Perfusion.

    R. Laing,1 S. Stubblefield,3 B. Ricky,1 S. Barnaby,2 M. Alfaifi,1 A. Ting,3 D. Mirza,2 P. Newsome,1 H. Mergental,2 S. Afford.1

    1Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; 2Liver Unit, University Hospital Birmingham, Birmingham, United Kingdom; 3Athersys Inc., Cleveland, OH

    Normothermic machine perfusion of the liver (NMP-L) has been used for organ preservation and viability testing of donor livers. Although previously proposed, delivery of cellular…
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