ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Machine preservation"

  • 2022 American Transplant Congress

    A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation

    S. Hosgood1, C. Callaghan2, C. Wilson3, G. Oniscu4, B. Phillips5, L. Bates3, L. Smith6, M. L. Nicholson7

    1Surgery, University of Cambridge, Cambridge, United Kingdom, 2Transplant, Guys & St Thomas's, London, United Kingdom, 3Transplant, Freeman Hospital, Newcastle, United Kingdom, 4Edinburgh Royal Infirmary, Edinburgh, United Kingdom, 5Transplant, Guy's & St Thomas's, London, United Kingdom, 6NHSBT, NHSBT, Bristol, United Kingdom, 7University of Cambridge, Cambridge, United Kingdom

    *Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…
  • 2022 American Transplant Congress

    Defatting of Steatotic Liver Grafts by Normothermic Ex Vivo Liver Machine Perfusion with 2,4 Dinitrophenol

    J. M. Gassner1, J. Michelotto1, S. Moosburner1, F. Strobl1, A. L. Birkenfeld2, A. Kurzbach2, G. Shulman3, X. Zhang3, M. Selzner4, Y. Noguchi4, J. Pratschke1, I. M. Sauer1, N. Raschzok1

    1Department of Surgery, Experimental Surgery, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, Internal, University Hospital Tübingen, Tübingen, Germany, 3Departments of Internal Medicine and Cellular & Molecular Physiology, Yale Diabetes Research Center, Yale School of Medicine, New Haven, CT, 4Multi Organ Transplant Program, Ajmera Family Transplant Center, Toronto General Hospital, University of Toronto, Toronto, ON, Canada

    *Purpose: The purpose of the study is to demonstrate that steatotic liver grafts can be defatted by normothermic ex vivo liver machine perfusion (NEVLP) with…
  • 2022 American Transplant Congress

    Characterisation of Kidney-Specific Extracellular Vesicles During Isolated Organ Normothermic Machine Perfusion

    J. Ashcroft1, T. L. Williams2, T. R. Elliott1, A. Marton1, S. A. Hosgood1, M. L. Nicholson1, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    *Purpose: Introduction: Normothermic machine perfusion (NMP) can evaluate and recondition deceased-donor kidneys but accurate biomarkers are needed to assess organ quality and to predict post-transplant…
  • 2022 American Transplant Congress

    Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)

    D. J. Reich1, A. Schlegel2, M. Rizzari3, D. Foley4, M. DeVera5, W. Chapman6, G. Roll7, A. Saharia8, C. Quintini9, S. Florman10, S. Merani11, S. Mao12, A. Pinna13, M. Akoad14, C. Kubal15, S. Alexopoulos16, H. Bohorquez17

    1Drexel University, Philadelphia, PA, 2Careggi U, Florence, Italy, 3Henry Ford, Detroit, MI, 4U Wisconsin, Madison, WI, 5Loma Linda, Loma Linda, CA, 6Washington U, Saint Louis, MO, 7UCSF, SF, CA, 8Methodist, Houston, TX, 9Cleveland Clinic, Cleveland, OH, 10Mount Sinai, NY, NY, 11U Nebraska, Omaha, NE, 12Mayo, Jacksonville, FL, 13Cleveland Clinic, Weston, FL, 14Lahey, Burlington, MA, 15Indiana U, Indianapolis, IN, 16Vanderbilt, Nashville, TN, 17Ochsner, New Orleans, LA

    *Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
  • 2022 American Transplant Congress

    Pulsatile Kidney Perfusion Improves Survival and Graft Function in High Acuity Combined Liver Kidney Transplant (CLKT) Recipients

    T. Liu1, G. Panayotova2, F. Paterno3, A. Amin2, L. Brown4, J. Guarrera5, K. Lunsford6

    1Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, Newark, NJ, 3Rutgers State University of New Jersey, Montclair, NJ, 4Rutgers New Jersey Medical School, Morris Plains, NJ, 5Surgery/ Transplant, Rutgers New Jersey Medical School, Newark, NJ, 6Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Due to underlying renal dysfunction, CLKT recipients tend to have higher medical acuity at baseline resulting in a higher likelihood of post-operative complications and…
  • 2022 American Transplant Congress

    Lipid Metabolism Profile of Human Kidneys During Ex Vivo Normothermic Perfusion

    J. Yu, I. Palma, S. Adams, J. Sageshima, P. Than, R. Perez

    UC Davis Medical Center, Sacramento, CA

    *Purpose: The kidney is a highly metabolic organ and lipids are an important energy source. In this study, we examined the lipid profiles of discarded…
  • 2022 American Transplant Congress

    A Multicenter Randomized Controlled Trial To Compare The Efficacy Of Ex-vivo Machine Perfusion With Static Cold Storage In Human Liver Transplantation: The University Of Maryland Experience

    J. Avruch1, N. Goussous2, S. Malik1, M. Pinedo1, R. Meier1, C. Bhati1, D. Maluf1, R. Barth3, J. Alvarez-Casas1

    1Transplant Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Transplant Surgery, University of California Davis Health, Davis, CA, 3University of Chicago, Chicago, IL

    *Purpose: There is accumulating clinical evidence of the benefit of normothermic ex-vivo machine perfusion (NMP) compared with traditional static cold storage of liver allografts prior…
  • 2022 American Transplant Congress

    Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia

    V. Boominathan1, M. Willman1, N. Battula2, A. Zarrinpar1, S. Duarte1

    1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK

    *Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…
  • 2022 American Transplant Congress

    Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study

    L. Lo Faro1, A. Thorne2, H. Huang3, P. Charles3, M. Kaisar1, S. Davis3, F. Dengu1, S. Shaheed1, J. Mulvey1, R. Fischer3, D. Nasralla4, B. Kessler3, H. Leuvenink2, P. Friend1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University Medical Center Groningen, Groningen, Netherlands, 3Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Royal Free London NHS Foundation Trust, London, United Kingdom

    *Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
  • 2022 American Transplant Congress

    Final Flow and Resistance During Cold Pulsatile Perfusion Preservation Do Have Value in Prediction of Deceased Donor Graft Survival After Adjusting for KDPI

    D. S. Keith, E. Lessmann

    Kidney Transplant, Sacred Heart Hospital, Pensacola, FL

    *Purpose: To determine whether cold pulsatile perfusion preservation (CPPP) parameters of flow and resistance provide additional data regarding deceased donor kidney graft survival after adjusting…
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