ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2015 American Transplant Congress

    CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant

    J. Zimmerer, S. Elzein, C. Wright, G. Bumgardner.

    Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.

    MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…
  • 2015 American Transplant Congress

    Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function

    T. Akimova,1 J. Diamond,2 D. Wilkes,3 D. Lederer,4 J. Christie,2 W. Hancock.1

    1Path & Lab Med, CHOP & UPenn, Philadelphia; 2Pulm, Allergy & Crit Care Med, UPenn, Philadelphia; 3Med, Microbiol & Immunol, Indiana Uni Sch of Med & Thoracic Transplant Prog, Indianapolis; 4Medicine, Columbia Uni, New York.

    Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…
  • 2015 American Transplant Congress

    Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice

    M. Martina,1 S. Bandapalle,2 S. Noel,2 A. Saxena,1 A. Hamad,1 H. Rabb.2

    1Pathology, Johns Hopkins University, Baltimore, MD; 2Medicine, Johns Hopkins University, Baltimore, MD.

    Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
  • 2015 American Transplant Congress

    Clinically Relevant Anti-TCR mAb Induction Plus Brief Rapamycin Therapy Can Achieve Long-Term Vascularized Composite Allograft (VCA) Survival

    L. Wang, A. Samanta, J. Huang, T. Bhatti, Z. Wang, R. Han, L. Levin, M. Levine, W. Hancock.

    CHOP/UPenn, Philadelphia.

    Aim: Current strategies for management of VCA recipients are adapted from solid organ transplant protocols, and almost universally employ induction therapy followed by maintenance triple…
  • 2015 American Transplant Congress

    Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients

    J. Leventhal,1 A. LeFever,2 A. Skaro,1 L. Gallon,1 J. Mathew,1 D. Stare,1 I. Konieczna,1 J. He,1 G. Johnson.3

    1Northwestern University, Chicago; 2Northwestern Memorial Hospital, Chicago; 3TRACT Therapeutics Inc., Chicago.

    Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…
  • 2015 American Transplant Congress

    Immunodeficiency Assessment in Pediatric Intestinal Failure Patients

    J. Garcia,1 T. Beduschi,1 C. Biaggi,2 E. Perez,2 A. Tekin,1 M. McGetrick,3 L. Cubley,1 P. Ruiz,1 J. Fan,1 S. Nishida,1 G. Selvaggi,1 R. Vianna.1

    1Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; 2Pediatrics, University of Miami Miller School of Medicine, Miami, FL; 3University of Miami Miller School of Medicine, Miami, FL.

    Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
  • 2015 American Transplant Congress

    Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment

    M. Duerr,1 K. Daemen,2 J. Keil,2 K. Budde,1 C. Falk.2

    1Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.

    In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…
  • 2015 American Transplant Congress

    Interference of Therapeutic Antibodies Used in Desensitization Protocols On Lymphocytotoxicity Crossmatch Results

    D. Milongo,1,3 G. Vieu,2,4,3 S. Blavy,2,4 A. Del Bello,1,3 F. Sallusto,5 L. Rostaing,1,3 N. Kamar,1,3 N. Congy-Jolivet.2,4,3

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; 3Université Toulouse III Paul-Sabatier, Toulouse, France; 4Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Department of Urology, CHU Rangueil, Toulouse, France.

    Background: Therapeutic antibodies used to desensitize patients awaiting a human leukocyte antigen (HLA) or ABO-mismatched graft are suspected to interfere with the lymphocytotoxicity crossmatch (LCT-XM)…
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