ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2015 American Transplant Congress

    Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients

    J. Leventhal,1 A. LeFever,2 A. Skaro,1 L. Gallon,1 J. Mathew,1 D. Stare,1 I. Konieczna,1 J. He,1 G. Johnson.3

    1Northwestern University, Chicago; 2Northwestern Memorial Hospital, Chicago; 3TRACT Therapeutics Inc., Chicago.

    Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…
  • 2015 American Transplant Congress

    Immunodeficiency Assessment in Pediatric Intestinal Failure Patients

    J. Garcia,1 T. Beduschi,1 C. Biaggi,2 E. Perez,2 A. Tekin,1 M. McGetrick,3 L. Cubley,1 P. Ruiz,1 J. Fan,1 S. Nishida,1 G. Selvaggi,1 R. Vianna.1

    1Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; 2Pediatrics, University of Miami Miller School of Medicine, Miami, FL; 3University of Miami Miller School of Medicine, Miami, FL.

    Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
  • 2015 American Transplant Congress

    Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment

    M. Duerr,1 K. Daemen,2 J. Keil,2 K. Budde,1 C. Falk.2

    1Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.

    In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…
  • 2015 American Transplant Congress

    Interference of Therapeutic Antibodies Used in Desensitization Protocols On Lymphocytotoxicity Crossmatch Results

    D. Milongo,1,3 G. Vieu,2,4,3 S. Blavy,2,4 A. Del Bello,1,3 F. Sallusto,5 L. Rostaing,1,3 N. Kamar,1,3 N. Congy-Jolivet.2,4,3

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; 3Université Toulouse III Paul-Sabatier, Toulouse, France; 4Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Department of Urology, CHU Rangueil, Toulouse, France.

    Background: Therapeutic antibodies used to desensitize patients awaiting a human leukocyte antigen (HLA) or ABO-mismatched graft are suspected to interfere with the lymphocytotoxicity crossmatch (LCT-XM)…
  • 2015 American Transplant Congress

    Impact of Alloreactivity On Intra-Graft T Cell Homeostasis Following Small Bowel Transplantation

    J. Zuber, B. Shonts, S. Lau, S. Coley, S. Yang, J. Weiner, S. DeWolf, D. Farber, Y. Shen, M. Martinez, T. Kato, M. Sykes.

    Columbia University Medical Center, New York.

    The impact of alloreactivity on the turnover rate, phenotype and repertoire of gut-resident lymphoid cells populating human intestinal allografts is unknown. We prospectively analyzed the…
  • 2015 American Transplant Congress

    Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients

    M. Dürr, J. Liu, K. Budde.

    Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.

    Objective: Regulatory T-cells (Tregs) are considered to play a crucial role in maintaining control of immune response following renal transplantation (Tx). So far, only limited…
  • 2015 American Transplant Congress

    Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients

    M. Yap,1,3 G. Tilly,1,3 M. Giral,1,2 S. Brouard,1,2 N. Degauque.1,2

    1UMR 1064, INSERM, Nantes, France; 2ITUN, CHU de Nantes, Nantes, France; 3Faculté de Médecine, Université de Nantes, Nantes, France.

    Objective. Historical classification to distinguish central memory (CM), naïve, effector memory (EM), and terminally-differentiated effector memory (TEMRA) CD8 T cells is based on CD45RA and…
  • 2015 American Transplant Congress

    Characterization of Peripheral Blood T and B Cells of Sensitized Kidney Transplant Recipients With Long Term Stable Graft Function

    N. Galante,1 M. Fernandes,1 F. Agena,1 A. Triboni,1 G. Freitas,1 A. Aguirre,1 W. Nahas,1 V. Coelho,2 E. David-Neto.1

    1Renal Transplant Service, Hospital das Clínicas - University of Sao Paulo School of Medicine, Sao Paulo, Brazil; 2Laboratory of Immunology, Heart Institute - University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

    We examined the phenotype of T and B cells of peripheral blood of sensitized kidney transplant recipients with stable graft function (GFR > 29mL/min) enrolled…
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