2016 American Transplant Congress
Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.
Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…2016 American Transplant Congress
Earlier Repletion of Lymphocytes After Alemtuzumab Induction Is Associated with a Lower Incidence of Infection Following Renal Transplantation.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Introduction: Alemtuzumab has been increasingly used as an induction agent in renal transplantation, although the optimal dose is unknown. We have previously reported that alemtuzumab…2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…2016 American Transplant Congress
Novel Function of CD4+ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…2015 American Transplant Congress
Impact of Alloreactivity On Intra-Graft T Cell Homeostasis Following Small Bowel Transplantation
Columbia University Medical Center, New York.
The impact of alloreactivity on the turnover rate, phenotype and repertoire of gut-resident lymphoid cells populating human intestinal allografts is unknown. We prospectively analyzed the…2015 American Transplant Congress
Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Objective: Regulatory T-cells (Tregs) are considered to play a crucial role in maintaining control of immune response following renal transplantation (Tx). So far, only limited…2015 American Transplant Congress
Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients
Objective. Historical classification to distinguish central memory (CM), naïve, effector memory (EM), and terminally-differentiated effector memory (TEMRA) CD8 T cells is based on CD45RA and…2015 American Transplant Congress
Characterization of Peripheral Blood T and B Cells of Sensitized Kidney Transplant Recipients With Long Term Stable Graft Function
We examined the phenotype of T and B cells of peripheral blood of sensitized kidney transplant recipients with stable graft function (GFR > 29mL/min) enrolled…2015 American Transplant Congress
Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes
1Boston Children's Hospital, Boston; 2Massachusetts General Hospital, Boston.
Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…
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