2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…2016 American Transplant Congress
Novel Function of CD4+ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…2016 American Transplant Congress
Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.
Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…2015 American Transplant Congress
CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant
Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…2015 American Transplant Congress
Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function
Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…2015 American Transplant Congress
Clinically Relevant Anti-TCR mAb Induction Plus Brief Rapamycin Therapy Can Achieve Long-Term Vascularized Composite Allograft (VCA) Survival
Aim: Current strategies for management of VCA recipients are adapted from solid organ transplant protocols, and almost universally employ induction therapy followed by maintenance triple…2015 American Transplant Congress
Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients
Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…2015 American Transplant Congress
Immunodeficiency Assessment in Pediatric Intestinal Failure Patients
Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
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