Articles tagged "Lymphocytes"

2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
M. Snyder,¹ T. Connors,² C. Marboe,³ L. Benvenuto,¹ L. Shah,¹ H. Robbins,¹ J. Hook,¹ F. D'Ovidio,⁴ M. Bacchetta,⁴ J. Sonnett,⁴ S. Arcasoy,¹ D. Farber.^4,5
¹Medicine, Columbia University Medical Center, New York, NY; ²Pediatrics, Columbia University Medical Center, New York, NY; ³Pathology, Columbia University Medical Center, New York, NY; ⁴Surgery, Columbia University Medical Center, New York, NY; ⁵Microbiology & Immunology, Columbia University Medical Center, New York, NY.
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
2018 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Trafficking through a Novel Mechanism of S1PR1 Regulation
M. Nicosia,¹ R. Fan,¹ S. Miyairi,¹ A. Beavers,¹ G. Farr,² P. McGuirk,² M. Pelletier,² A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics LLC, Cleveland, OH.
The ubiquitous water channels aquaporins mediate a variety of immune functions. We previously demonstrated that aquaporin 4 (AQP4) is expressed by CD4 and CD8 T…
2018 American Transplant Congress
Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts
W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.
THMRI, Houston, TX.
Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
2018 American Transplant Congress
Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival
S. Kodali,¹ H. Sandoval,¹ M. Chen,² J. Wang.¹
¹Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; ²Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.
Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
P. Cha, B. Houlihan, J. Kaiser, C. Cosentino, B. Monahan, A. Shukla, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…
2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
K. de Leur,^1,2 M. Clahsen-van Groningen,³ G. de Graav,¹ D. Hesselink,¹ J. Samsom,⁴ C. Baan,¹ K. Boer.¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; ³Pathology, Erasmus MC, Rotterdam, Netherlands; ⁴Pediatrics, Erasmus MC, Rotterdam, Netherlands
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…
2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
Y. Lei,¹ L. Chen,¹ Y. Wang,¹ A. Chong,¹ Y. Belkaid,² M.-L. Alegre.¹
¹Departments of Medicine and Surgery, University of Chicago, Chicago, IL; ²Immunity at Barrier Sites Initiative, NIAID, NIH, Bethesda
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…
2017 American Transplant Congress
Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ A. Albar,¹ P. Thevenot,³ K. Nunez,³ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:Immune factors are pivotal against disease progression after transplant in hepatocellular carcinoma (HCC). With chemoembolization (TACE) as a bridge to liver transplant, this study compares…
2017 American Transplant Congress
Immunosuppressive Treatment Alters Gut Microbiota and Modified Gut Microbiota Affects Immune Status.
Z. Zhang, Y. Xu, Q. Zhang, X. Hu.
Department of Urology, Beijing Chaoyang Hospital, CCMU, Beijing, China
Objectives: Immunosuppressive therapies could change the host-microbial interactions, especially gut microbiota, which is an important component in systemic immunity. We evaluated the relationship between immunosuppression…
2017 American Transplant Congress
Persistent Donor Antigen Leads to Dysfunctional CD4⁺Memory T Cell Development.
M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹
¹Medicine, University of Chicago, Chicago, IL; ²Surgery, University of Chicago, Chicago, IL; ³Chicago State University, Chicago, IL; ⁴Institute for Molecular Engineering, University of Chicago, Chicago, IL; ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
Tolerance to alloantigens is characterized by low alloreactive T cell responses upon restimulation with donor antigens, a state that can result from deletion of donor-specific…