Articles tagged "Lymphocytes"

2018 American Transplant Congress
Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
2018 American Transplant Congress
Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics
V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.
U Maryland, Baltimore, MD.
Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
2018 American Transplant Congress
Mechanisms of DEPTOR Function in CD4⁺ T Cell Subsets
J. Wedel,¹ K. Liu,¹ P. Sage,² M. Laplante,³ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston; ²Department of Microbiology and Immunobiology, Harvard Medical School, Boston; ³IUCP, Lavel University, Quebec, Canada.
We have previously observed that the cell intrinsic modulatory protein DEPTOR (DEP) stabilizes Foxp3 expression, enhances Treg function and inhibits Treg dedifferentiation. In vivo, sustained…
2018 American Transplant Congress
T cell Phenotypes Predict Infectious Risk in Transplanted Children
E. T. Chambers,¹ R. Ettenger,² H.-J. Lee,¹ C. Chan,¹ L. Stempora,¹ B. Warshaw,³ P. Grimm,⁴ E. F. Reed,² M. Sarwal,⁵ A. Kirk.¹
¹Pediatrics/Surgery, Duke University, Durham; ²Pediatrics, UCLA, Los Angeles; ³Pediatrics, Emory, Atlanta; ⁴Pediatrics, Stanford, Palo Alto; ⁵Surgery, UCSF, San Francisco.
AIM: Current monitoring strategies do not adequately differentiate infection from complications such as allograft rejection (AR). We aimed to identify peripheral T cell phenotypes that…
2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
P. Cha, B. Houlihan, J. Kaiser, C. Cosentino, B. Monahan, A. Shukla, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…
2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
K. de Leur,^1,2 M. Clahsen-van Groningen,³ G. de Graav,¹ D. Hesselink,¹ J. Samsom,⁴ C. Baan,¹ K. Boer.¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; ³Pathology, Erasmus MC, Rotterdam, Netherlands; ⁴Pediatrics, Erasmus MC, Rotterdam, Netherlands
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…
2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
Y. Lei,¹ L. Chen,¹ Y. Wang,¹ A. Chong,¹ Y. Belkaid,² M.-L. Alegre.¹
¹Departments of Medicine and Surgery, University of Chicago, Chicago, IL; ²Immunity at Barrier Sites Initiative, NIAID, NIH, Bethesda
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…
2017 American Transplant Congress
Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ A. Albar,¹ P. Thevenot,³ K. Nunez,³ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:Immune factors are pivotal against disease progression after transplant in hepatocellular carcinoma (HCC). With chemoembolization (TACE) as a bridge to liver transplant, this study compares…
2017 American Transplant Congress
Immunosuppressive Treatment Alters Gut Microbiota and Modified Gut Microbiota Affects Immune Status.
Z. Zhang, Y. Xu, Q. Zhang, X. Hu.
Department of Urology, Beijing Chaoyang Hospital, CCMU, Beijing, China
Objectives: Immunosuppressive therapies could change the host-microbial interactions, especially gut microbiota, which is an important component in systemic immunity. We evaluated the relationship between immunosuppression…
2017 American Transplant Congress
Persistent Donor Antigen Leads to Dysfunctional CD4⁺Memory T Cell Development.
M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹
¹Medicine, University of Chicago, Chicago, IL; ²Surgery, University of Chicago, Chicago, IL; ³Chicago State University, Chicago, IL; ⁴Institute for Molecular Engineering, University of Chicago, Chicago, IL; ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
Tolerance to alloantigens is characterized by low alloreactive T cell responses upon restimulation with donor antigens, a state that can result from deletion of donor-specific…