2018 American Transplant Congress
The Neutrophil to Lymphocyte Ratio is Confounded by MELD in Hepatocellular Carcinoma Patients Undergoing Liver Transplantation
Department of General Surgery Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Background: Biological markers such as the pre-operative neutrophil to lymphocyte ratio (NLR) have been suggested to be valuable indicators of recurrence and overall survival after…2018 American Transplant Congress
Modification of Macrophage Phenotype by the Magnetic Field
Objective. Macrophages play a crucial role in health, disease and chronic rejection of transplanted organs. Chronic rejection of transplanted organs remains unresolved issue in organ…2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…2018 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Trafficking through a Novel Mechanism of S1PR1 Regulation
1Immunology, Cleveland Clinic, Cleveland, OH; 2Aeromics LLC, Cleveland, OH.
The ubiquitous water channels aquaporins mediate a variety of immune functions. We previously demonstrated that aquaporin 4 (AQP4) is expressed by CD4 and CD8 T…2017 American Transplant Congress
Senescence and Uremia Effects in Circulating T Cells Diverge in TREG Population and Cause T Cell Shift to a Memory Profile.
Elderly kidney transplant recipients(EKtx) have higher malignancies and infections rates, but lower acute rejection incidence. Senescence seems to result in shift to memory profile and…2017 American Transplant Congress
Risks Associated with Recombinant IL2 Therapy in Renal Transplantation.
Brigham and Women's Hospital, Boston
Regulatory T cells are critical to allograft survival. We report a pilot study of safety and tolerability of low dose recombinant IL2 (rIL2), 1x106 units/m2/day…2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…2017 American Transplant Congress
Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
Purpose:Immune factors are pivotal against disease progression after transplant in hepatocellular carcinoma (HCC). With chemoembolization (TACE) as a bridge to liver transplant, this study compares…
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