ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2019 American Transplant Congress

    CD19+ Cell Behavior in the 12 Months Following a Single Dose of Rituximab in Patients with Humoral Rejection: Clinical and Histological Outcomes

    L. Marino, I. A. Martínez-Juárez, J. R. Marino-Sánchez, J. I. Santander-Velez, F. Zamora, H. Juarez, R. Vazquez, L. Llorente, G. Lima, A. Cohen-Bucay, L. E. Morales-Buenrostro

    Nephrology, INCMNSZ, Mexico City, Mexico

    *Purpose: Treatment of antibody mediated rejection (ABMR) commonly includes rituximab, but the dose needed is not yet well defined. It has been suggested that a…
  • 2018 American Transplant Congress

    Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts

    W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    THMRI, Houston, TX.

    Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
  • 2018 American Transplant Congress

    Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival

    S. Kodali,1 H. Sandoval,1 M. Chen,2 J. Wang.1

    1Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; 2Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.

    Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
  • 2018 American Transplant Congress

    Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration

    L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
  • 2018 American Transplant Congress

    Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics

    V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.

    U Maryland, Baltimore, MD.

    Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
  • 2018 American Transplant Congress

    Mechanisms of DEPTOR Function in CD4+ T Cell Subsets

    J. Wedel,1 K. Liu,1 P. Sage,2 M. Laplante,3 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston; 2Department of Microbiology and Immunobiology, Harvard Medical School, Boston; 3IUCP, Lavel University, Quebec, Canada.

    We have previously observed that the cell intrinsic modulatory protein DEPTOR (DEP) stabilizes Foxp3 expression, enhances Treg function and inhibits Treg dedifferentiation. In vivo, sustained…
  • 2018 American Transplant Congress

    T cell Phenotypes Predict Infectious Risk in Transplanted Children

    E. T. Chambers,1 R. Ettenger,2 H.-J. Lee,1 C. Chan,1 L. Stempora,1 B. Warshaw,3 P. Grimm,4 E. F. Reed,2 M. Sarwal,5 A. Kirk.1

    1Pediatrics/Surgery, Duke University, Durham; 2Pediatrics, UCLA, Los Angeles; 3Pediatrics, Emory, Atlanta; 4Pediatrics, Stanford, Palo Alto; 5Surgery, UCSF, San Francisco.

    AIM: Current monitoring strategies do not adequately differentiate infection from complications such as allograft rejection (AR). We aimed to identify peripheral T cell phenotypes that…
  • 2018 American Transplant Congress

    Immune Phenotyping in a Pediatric Multicenter Transplant Study: Suitability of a Pre-Formulated Dry Antibody Panel System

    S. Urschel,1 L. Ionescu,1 T. Blydt-Hansen,3 B. Foster,5 S. Mital,2 U. Allan,2 S. Iveson,3 L. Hamiwka,4 J. Yap,1 V. Phan,5 P. Birk,6 L. West,1 M. Levings.3

    1U of Alberta, Edmonton, Canada; 2Sickkids, Toronto, Canada; 3U of BC, Vancouver, Canada; 4U of Calgary, Calgary, Canada; 5Montreal Children's, Montreal, Canada; 6U Manitoba, Winnipeg, Canada.

    Background:Flow cytometric immune-phenotyping is influenced by cryopreservation and inter-laboratory variability limiting comparability in multi center studies. The Duraclone™ system (DC) provides optimized pre-mixed dry antibody…
  • 2018 American Transplant Congress

    DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients

    J. Schaenman, X. Zhou, R. Guo, M. Rossetti, E. Liang, B. Abdalla, E. Lum, S. Bunnapradist, G. Danovitch, E. Reed, D. Elashoff.

    David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Introduction: Older transplant recipients experience increased rates of infection and death, but decreased rates of rejection, suggesting a role of immune dysfunction. Analysis of DNA…
  • 2018 American Transplant Congress

    Patients Converted to Belatacept Show Different Immunophenotyping Compared with De Novo Belatacept-Treated Patients

    M. Rial,1 F. Caro,2 A. Nella,2 D. Guerrieri,2 L. León,1 P. Uva,1 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrología, Nephrology, Buenos Aires, Argentina; 2CEFYBO, UBA, CONICET, Buenos Aires, Argentina.

    The incidence of adverse clinical events mainly in early, but not late post-transplantation such as an increased rate of acute rejection precludes the use of…
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