ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2019 American Transplant Congress

    The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis

    B. H. Ozdemir1, F. N. Ozdemir2, A. Ok Atılgan1, E. Akcay1, M. Haberal3

    1Pathology, Baskent University, Ankara, Turkey, 2Nephrology, Baskent University, Ankara, Turkey, 3Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Inversion of the CD4/CD8 ratio (
  • 2019 American Transplant Congress

    Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile

    E. David-Neto1, G. Ramos de Freitas1, M. Fernandes1, F. Agena1, F. Brambate Carvalhinho Lemos1, F. Jota de Paula1, V. Coelho2, N. Zocoler Galante1

    1Renal Transplantation Service, Hospital das Clínicas - University of São Paulo School of Medicine, Sao Paulo, Brazil, 2Laboratory of Immunology – LIM 19, Heart Institute - University of São Paulo School of Medicine, Sao Paulo, Brazil

    *Purpose: Despite the growing number of elderly kidney transplant (Ktx) recipientes few studies describe the effects of immunosuppression on this group. We evaluated the immunological…
  • 2019 American Transplant Congress

    Single-center Retrospective Analysis of Prophylaxis and Treatment of Pneumocystis Carinii Pneumonia in Patients with Poor Renal Function

    Y. Fu, J. Pan, Z. Shen

    Kidney-Pancreas Transplant Department., Tianjin First Central Hospital, Tianjin, China

    *Purpose: Pneumocystis carinii pneumonia (PcP) is a potentially life-threatening complication in renal transplant recipients. Although the use of trimethoprim-sulfamethoxazole (TMP-SMX) chemoprophylaxis after kidney transplantation is…
  • 2019 American Transplant Congress

    Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney

    S. Noel1, J. T. Kurzhagen1, S. Lee1, M. Sadasivam2, A. R. Hamad2, P. M. Pierorazio3, H. Rabb1

    1Medicine, Johns Hopkins University, Baltimore, MD, 2Pathology, Johns Hopkins University, Baltimore, MD, 3Urology, Johns Hopkins University, Baltimore, MD

    *Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
  • 2019 American Transplant Congress

    A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation

    R. Ishii1, I. Masako1, H. Katsumata1, T. Kanzawa1, T. Yamakawa1, H. Ishigooka1, T. Hirai1, K. Saiga1, M. Okumi1, Y. Ishii2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Vaccine Innovation Laboratory RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), Kanagawa, Japan

    *Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…
  • 2019 American Transplant Congress

    Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes

    B. Motyka1, J. Fersovich1, M. Sulzer1, I. Adam1, J. Pearcey1, K. Tao1, C. W. Cairo2, P. J. Cowan3, L. J. West1

    1Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, 2Department of Chemistry, University of Alberta, Edmonton, AB, Canada, 3Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia

    *Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
  • 2019 American Transplant Congress

    CD19+ Cell Behavior in the 12 Months Following a Single Dose of Rituximab in Patients with Humoral Rejection: Clinical and Histological Outcomes

    L. Marino, I. A. Martínez-Juárez, J. R. Marino-Sánchez, J. I. Santander-Velez, F. Zamora, H. Juarez, R. Vazquez, L. Llorente, G. Lima, A. Cohen-Bucay, L. E. Morales-Buenrostro

    Nephrology, INCMNSZ, Mexico City, Mexico

    *Purpose: Treatment of antibody mediated rejection (ABMR) commonly includes rituximab, but the dose needed is not yet well defined. It has been suggested that a…
  • 2019 American Transplant Congress

    Undernutrition and Leptin Deficiency Modulates T Cell Immunity in Transplantation

    E. David1, M. Zhu2, B. Bennett2, D. Cheng1, A. Nichols1, W. Parker2, P. Schroder2, N. McIver1, A. Kirk2, E. Chambers1

    1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC

    *Purpose: We have previously shown an association between undernutrition and the development of viremia in transplanted children. While undernutrition is associated with impaired T cell…
  • 2019 American Transplant Congress

    Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction

    J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer

    Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
  • 2019 American Transplant Congress

    B Cell Immunophenotypes in Transplantation

    M. Cascalho1, M. de Mattos-Barbosa2, E. A. Farkash3, J. L. Platt2

    1University of Michigan, Ann Arbor, MI, 2Surgery, University of Michigan, Ann Arbor, MI, 3Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
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