Articles tagged "Lymphocytes"

2019 American Transplant Congress
The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis
B. H. Ozdemir¹, F. N. Ozdemir², A. Ok Atılgan¹, E. Akcay¹, M. Haberal³
¹Pathology, Baskent University, Ankara, Turkey, ²Nephrology, Baskent University, Ankara, Turkey, ³Transplantation, Baskent University, Ankara, Turkey
*Purpose: Inversion of the CD4/CD8 ratio (
2019 American Transplant Congress
Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile
E. David-Neto¹, G. Ramos de Freitas¹, M. Fernandes¹, F. Agena¹, F. Brambate Carvalhinho Lemos¹, F. Jota de Paula¹, V. Coelho², N. Zocoler Galante¹
¹Renal Transplantation Service, Hospital das Clínicas - University of São Paulo School of Medicine, Sao Paulo, Brazil, ²Laboratory of Immunology – LIM 19, Heart Institute - University of São Paulo School of Medicine, Sao Paulo, Brazil
*Purpose: Despite the growing number of elderly kidney transplant (Ktx) recipientes few studies describe the effects of immunosuppression on this group. We evaluated the immunological…
2019 American Transplant Congress
Single-center Retrospective Analysis of Prophylaxis and Treatment of Pneumocystis Carinii Pneumonia in Patients with Poor Renal Function
Y. Fu, J. Pan, Z. Shen
Kidney-Pancreas Transplant Department., Tianjin First Central Hospital, Tianjin, China
*Purpose: Pneumocystis carinii pneumonia (PcP) is a potentially life-threatening complication in renal transplant recipients. Although the use of trimethoprim-sulfamethoxazole (TMP-SMX) chemoprophylaxis after kidney transplantation is…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation
R. Ishii¹, I. Masako¹, H. Katsumata¹, T. Kanzawa¹, T. Yamakawa¹, H. Ishigooka¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, Y. Ishii², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Vaccine Innovation Laboratory RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), Kanagawa, Japan
*Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
CD19+ Cell Behavior in the 12 Months Following a Single Dose of Rituximab in Patients with Humoral Rejection: Clinical and Histological Outcomes
L. Marino, I. A. Martínez-Juárez, J. R. Marino-Sánchez, J. I. Santander-Velez, F. Zamora, H. Juarez, R. Vazquez, L. Llorente, G. Lima, A. Cohen-Bucay, L. E. Morales-Buenrostro
Nephrology, INCMNSZ, Mexico City, Mexico
*Purpose: Treatment of antibody mediated rejection (ABMR) commonly includes rituximab, but the dose needed is not yet well defined. It has been suggested that a…
2019 American Transplant Congress
Undernutrition and Leptin Deficiency Modulates T Cell Immunity in Transplantation
E. David¹, M. Zhu², B. Bennett², D. Cheng¹, A. Nichols¹, W. Parker², P. Schroder², N. McIver¹, A. Kirk², E. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: We have previously shown an association between undernutrition and the development of viremia in transplanted children. While undernutrition is associated with impaired T cell…
2019 American Transplant Congress
Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction
J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer
Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
2019 American Transplant Congress
B Cell Immunophenotypes in Transplantation
M. Cascalho¹, M. de Mattos-Barbosa², E. A. Farkash³, J. L. Platt²
¹University of Michigan, Ann Arbor, MI, ²Surgery, University of Michigan, Ann Arbor, MI, ³Pathology, University of Michigan, Ann Arbor, MI
*Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…