Articles tagged "Lymphocytes"

2019 American Transplant Congress
Post-Transplant Lymphopenia is Associated with Higher Risk of Graft Failure, Death and Viral Infections
A. Dujardin¹, M. Lorent², C. Kerleau¹, S. Brouard³, M. Giral¹
¹Nephrology, Nantes University Hospital, Nantes, France, ²UMR_S 1246, INSERM, Nantes, France, ³CRTI UMR 1064, Inserm, Nantes, France
*Purpose: The transplantation field needs biomarkers to assess the level of immunosuppression. In this study, we aimed to analyze the independent correlation between the number…
2019 American Transplant Congress
High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation
T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹
¹University of Alberta, Edmonton, AB, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Université de Montréal, Montreal, QC, Canada
*Purpose: Allergic disorders (AD) occur more frequently in children after transplantation (Tx) compared to healthy children, reflecting an imbalance of the immune system in the…
2019 American Transplant Congress
Transplantation Alone Induces Myeloid-Derived Suppressor Cells Which Can Suppress T Cell Responses
Y. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are a naturally occurring, heterogeneous population of highly immunosuppressive CD11b+GR-1+ cells that expand in response to inflammatory conditions. MDSCs develop…
2019 American Transplant Congress
Myeloid Derived Suppressor Cells (MDSC) Home to the Allograft and Can Control T Cell Responses
Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are a naturally occurring, heterogeneous population of highly immunosuppressive CD11b+GR-1+ myeloid cells that expand in response to inflammatory conditions. Although…
2019 American Transplant Congress
The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis
B. H. Ozdemir¹, F. N. Ozdemir², A. Ok Atılgan¹, E. Akcay¹, M. Haberal³
¹Pathology, Baskent University, Ankara, Turkey, ²Nephrology, Baskent University, Ankara, Turkey, ³Transplantation, Baskent University, Ankara, Turkey
*Purpose: Inversion of the CD4/CD8 ratio (
2019 American Transplant Congress
Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile
E. David-Neto¹, G. Ramos de Freitas¹, M. Fernandes¹, F. Agena¹, F. Brambate Carvalhinho Lemos¹, F. Jota de Paula¹, V. Coelho², N. Zocoler Galante¹
¹Renal Transplantation Service, Hospital das Clínicas - University of São Paulo School of Medicine, Sao Paulo, Brazil, ²Laboratory of Immunology – LIM 19, Heart Institute - University of São Paulo School of Medicine, Sao Paulo, Brazil
*Purpose: Despite the growing number of elderly kidney transplant (Ktx) recipientes few studies describe the effects of immunosuppression on this group. We evaluated the immunological…
2019 American Transplant Congress
Single-center Retrospective Analysis of Prophylaxis and Treatment of Pneumocystis Carinii Pneumonia in Patients with Poor Renal Function
Y. Fu, J. Pan, Z. Shen
Kidney-Pancreas Transplant Department., Tianjin First Central Hospital, Tianjin, China
*Purpose: Pneumocystis carinii pneumonia (PcP) is a potentially life-threatening complication in renal transplant recipients. Although the use of trimethoprim-sulfamethoxazole (TMP-SMX) chemoprophylaxis after kidney transplantation is…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation
R. Ishii¹, I. Masako¹, H. Katsumata¹, T. Kanzawa¹, T. Yamakawa¹, H. Ishigooka¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, Y. Ishii², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Vaccine Innovation Laboratory RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), Kanagawa, Japan
*Purpose: Tregs play a critical role in immune tolerance. If Tregs can be administered to patients suffering from immune disorders, most therapies employing existing immunosuppressants…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…