2020 American Transplant Congress
Absolute Lymphocyte Count: Is There a “Safety Corridor?”
*Purpose: Iatrogenic suppression of T cells is intended to prevent rejection after solid organ transplantation (SOT). This is complicated by opportunistic infections, most notably cytomegalovirus…2020 American Transplant Congress
A Single-Cell Transcriptome Atlas of 15 Adult Human Organs
*Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…2020 American Transplant Congress
DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…2020 American Transplant Congress
Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells
*Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…2020 American Transplant Congress
Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…2019 American Transplant Congress
Undernutrition and Leptin Deficiency Modulates T Cell Immunity in Transplantation
1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC
*Purpose: We have previously shown an association between undernutrition and the development of viremia in transplanted children. While undernutrition is associated with impaired T cell…2019 American Transplant Congress
Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction
Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…2019 American Transplant Congress
B Cell Immunophenotypes in Transplantation
*Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
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