Articles tagged "Lymphocytes"

2020 American Transplant Congress
Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation
K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
L. M. Christensen¹, T. Akimova², R. Han¹, L. Wang¹, A. Samanta¹, W. W. Hancock²
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…
2020 American Transplant Congress
Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells
B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng
Pathology, University of Western Ontario-LHSC, London, ON, Canada
*Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
B. Kim¹, E. Kim², J. Kim², H. Choi³, H. Lee², J. Lee⁴, M. Kim⁴, Y. Kim⁴, K. Huh⁴
¹Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
2020 American Transplant Congress
Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation
M. W. Shirkey, L. Li, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Paluskievicz, J. Bromberg
U. Maryland, Baltimore, MD
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…
2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
J. Vetter¹, A. Heinzel², C. Aschauer², R. Reindl-Schwaighofer², K. Jelencsics², K. Hu², R. Oberbauer², S. Winkler¹, S. Schaller¹
¹Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, ²Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
2019 American Transplant Congress
High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation
T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹
¹University of Alberta, Edmonton, AB, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Université de Montréal, Montreal, QC, Canada
*Purpose: Allergic disorders (AD) occur more frequently in children after transplantation (Tx) compared to healthy children, reflecting an imbalance of the immune system in the…
2019 American Transplant Congress
Transplantation Alone Induces Myeloid-Derived Suppressor Cells Which Can Suppress T Cell Responses
Y. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are a naturally occurring, heterogeneous population of highly immunosuppressive CD11b+GR-1+ cells that expand in response to inflammatory conditions. MDSCs develop…
2019 American Transplant Congress
Myeloid Derived Suppressor Cells (MDSC) Home to the Allograft and Can Control T Cell Responses
Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are a naturally occurring, heterogeneous population of highly immunosuppressive CD11b+GR-1+ myeloid cells that expand in response to inflammatory conditions. Although…