ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2022 American Transplant Congress

    Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation

    W. J. Rifkin1, J. Trilles1, P. S. Rabbani1, O. C. Onuh1, B. E. Gelb2, D. J. Ceradini1, E. D. Rodriguez1

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…
  • 2021 American Transplant Congress

    Harnessing Innate Lymphoid Cells to Prevent Graft-versus Host Disease

    K. T. Reid1, S. Q. Crome2

    1Immunology, University of Toronto, Toronto, ON, Canada, 2Ajmera Transplant Centre, TGHRI, University Health Network, Toronto, ON, Canada

    *Purpose: Determine whether human innate lymphoid cells (ILCs) can be isolated, expanded and used in cell-based therapies to prevent Graft-versus Host Disease (GvHD) .*Methods: ILC2s…
  • 2021 American Transplant Congress

    The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation

    E. S. Crichton, S. Zeng, I. Badell

    Emory University, Atlanta, GA

    *Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
  • 2021 American Transplant Congress

    Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3

    F. Fueyo-Gonzalez1, G. Vilanova2, M. Fribourg1

    1Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 2LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain

    *Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena2, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
  • 2021 American Transplant Congress

    Pre-transplant Prognostic  Nutritional  Index  Predicts  Short-term  Outcomes  After  Liver Transplantation

    E. Lisznyai, T. Kitajima, K. Delvecchio, A. Mohamed, S. Yeddula, T. Shamaa, T. Ivanics, K. Collins, M. Rizzari, A. Yoshida, M. Abouljoud, S. Nagai

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: To understand the importance of pre-transplant nutritional status in optimizing liver transplant outcomes.*Methods: The prognostic nutritional index (PNI) is a  serum  marker of nutrition…
  • 2020 American Transplant Congress

    Absolute Lymphocyte Count: Is There a “Safety Corridor?”

    G. Elhelou1, B. Lahr2, R. Razonable3

    1Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Medicine, Division of Infectious Disease, Mayo Clinic, Rochester, MN

    *Purpose: Iatrogenic suppression of T cells is intended to prevent rejection after solid organ transplantation (SOT). This is complicated by opportunistic infections, most notably cytomegalovirus…
  • 2020 American Transplant Congress

    A Single-Cell Transcriptome Atlas of 15 Adult Human Organs

    Z. Guo1, S. He2, L. Wang1, Y. Liu2, J. Xu1, J. Bei2, X. He1

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2The Cancer Centre of Sun Yat-Sen University, Guangzhou, China

    *Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…
  • 2020 American Transplant Congress

    DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation

    J. Wedel1, M. Maslyar1, S. Kong1, M. Laplante2, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada

    *Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
  • 2020 American Transplant Congress

    Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells

    A. B. Morris, D. F. Pinelli, D. Liu, M. L. Ford

    Emory University, Atlanta, GA

    *Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…
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