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American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2022 American Transplant Congress

    PTLD Suspected by Visualization of Atypical Urinary Lymphocytes

    J. Huidobro E1, F. Anghileri2, P. Troncoso3, A. Huete4, P. Downey1

    1Nephrology, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Clinical Laboratories, Pontificia Universidad Catolica de Chile, Santiago, Chile, 3Urology, Pontificia Universidad Catolica de Chile, Santiago, Chile, 4Radiology, Pontificia Universidad Catolica de Chile, Santiago, Chile

    *Purpose: Urinalysis has been used for the detection of acute rejection but visualization of atypical lymphocytes in the urine sediment as an early sign of…
  • 2021 American Transplant Congress

    Harnessing Innate Lymphoid Cells to Prevent Graft-versus Host Disease

    K. T. Reid1, S. Q. Crome2

    1Immunology, University of Toronto, Toronto, ON, Canada, 2Ajmera Transplant Centre, TGHRI, University Health Network, Toronto, ON, Canada

    *Purpose: Determine whether human innate lymphoid cells (ILCs) can be isolated, expanded and used in cell-based therapies to prevent Graft-versus Host Disease (GvHD) .*Methods: ILC2s…
  • 2021 American Transplant Congress

    The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation

    E. S. Crichton, S. Zeng, I. Badell

    Emory University, Atlanta, GA

    *Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
  • 2021 American Transplant Congress

    Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3

    F. Fueyo-Gonzalez1, G. Vilanova2, M. Fribourg1

    1Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 2LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain

    *Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena2, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
  • 2021 American Transplant Congress

    Pre-transplant Prognostic  Nutritional  Index  Predicts  Short-term  Outcomes  After  Liver Transplantation

    E. Lisznyai, T. Kitajima, K. Delvecchio, A. Mohamed, S. Yeddula, T. Shamaa, T. Ivanics, K. Collins, M. Rizzari, A. Yoshida, M. Abouljoud, S. Nagai

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: To understand the importance of pre-transplant nutritional status in optimizing liver transplant outcomes.*Methods: The prognostic nutritional index (PNI) is a  serum  marker of nutrition…
  • 2020 American Transplant Congress

    Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells

    B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng

    Pathology, University of Western Ontario-LHSC, London, ON, Canada

    *Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
  • 2020 American Transplant Congress

    Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells

    B. Kim1, E. Kim2, J. Kim2, H. Choi3, H. Lee2, J. Lee4, M. Kim4, Y. Kim4, K. Huh4

    1Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of

    *Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
  • 2020 American Transplant Congress

    Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation

    M. W. Shirkey, L. Li, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Paluskievicz, J. Bromberg

    U. Maryland, Baltimore, MD

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…
  • 2020 American Transplant Congress

    A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data

    J. Vetter1, A. Heinzel2, C. Aschauer2, R. Reindl-Schwaighofer2, K. Jelencsics2, K. Hu2, R. Oberbauer2, S. Winkler1, S. Schaller1

    1Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, 2Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria

    *Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
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